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OOEP oocyte expressed protein [ Homo sapiens (human) ]

Gene ID: 441161, updated on 13-Oct-2022

Summary

Official Symbol
OOEPprovided by HGNC
Official Full Name
oocyte expressed proteinprovided by HGNC
Primary source
HGNC:HGNC:21382
See related
Ensembl:ENSG00000203907 MIM:611689; AllianceGenome:HGNC:21382
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KHDC2; FLOPED; HOEP19; C6orf156
Summary
Predicted to enable RNA binding activity. Predicted to be involved in several processes, including cytoskeleton organization; positive regulation of double-strand break repair via homologous recombination; and positive regulation of meiotic nuclear division. Predicted to act upstream of or within several processes, including embryo implantation; in utero embryonic development; and protein phosphorylation. Located in cytoplasm and nucleus. Part of subcortical maternal complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis (RPKM 5.4), placenta (RPKM 0.5) and 1 other tissue See more
Orthologs
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Genomic context

See OOEP in Genome Data Viewer
Location:
6q13
Exon count:
3
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (73368555..73369897, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (74545253..74546595, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (74078278..74079620, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene developmental pluripotency associated 5 Neighboring gene KH domain containing 3 like, subcortical maternal complex member Neighboring gene OOEP antisense RNA 1 Neighboring gene ribosomal protein L39 pseudogene 3 Neighboring gene ribosomal protein S6 pseudogene 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in actin filament organization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in biological_process ND
No biological Data available
more info
 
involved_in embryonic pattern specification IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in establishment of spindle localization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in establishment or maintenance of apical/basal cell polarity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of double-strand break repair ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of double-strand break repair via homologous recombination ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of meiotic nuclear division ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of cell division ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of establishment of protein localization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of protein localization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in replication fork processing ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in cell cortex ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of protein-containing complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of subcortical maternal complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
oocyte-expressed protein homolog
Names
KH homology domain containing 2
KH homology domain-containing protein 2
oocyte and embryo protein 19
oocyte expressed protein homolog (dog)
oocyte- and embryo-specific protein 19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080507.3NP_001073976.1  oocyte-expressed protein homolog

    See identical proteins and their annotated locations for NP_001073976.1

    Status: VALIDATED

    Source sequence(s)
    AC019205, KF459597
    Consensus CDS
    CCDS47451.1
    UniProtKB/Swiss-Prot
    A6NGQ2, A9UIB7
    Related
    ENSP00000359384.5, ENST00000370359.6
    Conserved Domains (1) summary
    pfam16005
    Location:36116
    MOEP19; KH-like RNA-binding domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    73368555..73369897 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047418829.1XP_047274785.1  oocyte-expressed protein homolog isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    74545253..74546595 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)