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TMEM150C transmembrane protein 150C [ Homo sapiens (human) ]

Gene ID: 441027, updated on 13-Mar-2020

Summary

Official Symbol
TMEM150Cprovided by HGNC
Official Full Name
transmembrane protein 150Cprovided by HGNC
Primary source
HGNC:HGNC:37263
See related
Ensembl:ENSG00000249242 MIM:617292
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TTN3
Summary
This gene encodes a transmembrane protein component of a mechanosensitve ion channel that is activated by mechanical stimuli in various cell types and confers slowly adapting, mechanically activated currents in dorsal root ganglion neurons. Mechanically activated ion channels are sensors that are critical for hearing, touch, pain, and blood pressure regulation. [provided by RefSeq, Jul 2017]
Expression
Ubiquitous expression in ovary (RPKM 19.6), adrenal (RPKM 16.2) and 23 other tissues See more
Orthologs

Genomic context

See TMEM150C in Genome Data Viewer
Location:
4q21.22
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (82483176..82562253, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (83404329..83483595, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene enolase-phosphatase 1 Neighboring gene syncytin-1-like Neighboring gene ribosomal protein L7a pseudogene 26 Neighboring gene ribosomal protein S6 pseudogene Neighboring gene Sharpr-MPRA regulatory region 10449 Neighboring gene protein tyrosine phosphatase non-receptor type 11 pseudogene Neighboring gene long intergenic non-protein coding RNA 575

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Homology

Clone Names

  • FLJ12993

Gene Ontology Provided by GOA

Function Evidence Code Pubs
mechanosensitive ion channel activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cellular response to mechanical stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
proprioception ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
lysosomal membrane TAS
Traceable Author Statement
more info
PubMed 
lysosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
transmembrane protein 150C
Names
tentonin 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080506.3NP_001073975.1  transmembrane protein 150C isoform 1

    See identical proteins and their annotated locations for NP_001073975.1

    Status: REVIEWED

    Source sequence(s)
    AC067942, BC147019, BF508344
    Consensus CDS
    CCDS47087.1
    UniProtKB/Swiss-Prot
    B9EJG8
    Related
    ENSP00000403438.2, ENST00000449862.7
    Conserved Domains (1) summary
    pfam10277
    Location:8217
    Frag1; Frag1/DRAM/Sfk1 family
  2. NM_001353454.2NP_001340383.1  transmembrane protein 150C isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC067942, AK297434, BF508344
    Conserved Domains (1) summary
    pfam10277
    Location:38247
    Frag1; Frag1/DRAM/Sfk1 family
  3. NM_001353455.2NP_001340384.1  transmembrane protein 150C isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC067942, AK297512, BF508344
    Conserved Domains (1) summary
    pfam10277
    Location:8142
    Frag1; Frag1/DRAM/Sfk1 family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    82483176..82562253 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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