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MAP1LC3C microtubule associated protein 1 light chain 3 gamma [ Homo sapiens (human) ]

Gene ID: 440738, updated on 7-Aug-2022

Summary

Official Symbol
MAP1LC3Cprovided by HGNC
Official Full Name
microtubule associated protein 1 light chain 3 gammaprovided by HGNC
Primary source
HGNC:HGNC:13353
See related
Ensembl:ENSG00000197769 MIM:609605; AllianceGenome:HGNC:13353
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LC3C; ATG8J
Summary
Autophagy is a highly regulated bulk degradation process that plays an important role in cellular maintenance and development. MAP1LC3C is an ortholog of the yeast autophagosome protein Atg8 (He et al., 2003 [PubMed 12740394]).[supplied by OMIM, Nov 2010]
Expression
Biased expression in placenta (RPKM 3.9), lung (RPKM 1.9) and 9 other tissues See more
Orthologs
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Genomic context

See MAP1LC3C in Genome Data Viewer
Location:
1q43
Exon count:
5
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (241995490..242001393, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (241407557..241411171, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (242158792..242162400, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene beclin 2 Neighboring gene cofilin 1 pseudogene 4 Neighboring gene RNA, U6 small nuclear 1139, pseudogene Neighboring gene tubulin beta 8 class VIII pseudogene 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef HIV-1 Nef-treated mesenchymal stem cells downregulates the conversion of LC3I to LC3II, reflecting a decrease in autophagic efflux in cells PubMed
Vif vif HIV-1 Vif binds more strongly to autophagy-related protein 4 (ATG4)-cleaved form I (LC3-I) than to ATG4-cleaved form II (LC3-II) in an A3G-independent manner PubMed
vif The domain 144-159 inside the SOCS box-like motif of HIV-1 Vif and the glycine 120 of microtubule-associated protein light chain 3 (LC3) are required for the binding between Vif and LC3 PubMed
vif GST pull-down assay demonstrates that HIV-1 Vif physically interacts with light chain 3 proteins LC3A, LC3B, and LC3C in HEK cells PubMed
capsid gag HIV-1 CA co-localizes with LC3 in Jurkat cells and primary CD4+ T cells PubMed
retropepsin gag-pol HIV-1 protease extensively cleaves microtubule-associated proteins 1 and 2 and completely inhibits microtubule assembly PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in aggrephagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in autophagosome maturation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in autophagosome maturation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in autophagy of mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to nitrogen starvation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to starvation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in macroautophagy IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in macroautophagy IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein exit from endoplasmic reticulum IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in autophagosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in autophagosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in autophagosome ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
is_active_in autophagosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in autophagosome membrane TAS
Traceable Author Statement
more info
 
located_in cytoplasmic ribonucleoprotein granule IDA
Inferred from Direct Assay
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in endomembrane system IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
located_in organelle membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

General protein information

Preferred Names
microtubule-associated proteins 1A/1B light chain 3C
Names
LC3-like protein 2
MAP1 light chain 3-like protein 2
MAP1 light chain 3-like protein 3
MAP1A/MAP1B LC3 C
MAP1A/MAP1B light chain 3 C
autophagy-related protein LC3 C
autophagy-related ubiquitin-like modifier LC3 C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004343.3NP_001004343.1  microtubule-associated proteins 1A/1B light chain 3C

    See identical proteins and their annotated locations for NP_001004343.1

    Status: VALIDATED

    Source sequence(s)
    AF276659, BC127722, BX571673, CN260933
    Consensus CDS
    CCDS31074.1
    UniProtKB/Swiss-Prot
    A2RUP0, Q9BXW4
    Related
    ENSP00000349785.3, ENST00000357246.4
    Conserved Domains (1) summary
    cd01611
    Location:13126
    GABARAP; Ubiquitin domain of GABA-receptor-associated protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    241995490..242001393 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005273139.4XP_005273196.1  microtubule-associated proteins 1A/1B light chain 3C isoform X1

    See identical proteins and their annotated locations for XP_005273196.1

    UniProtKB/Swiss-Prot
    A2RUP0, Q9BXW4
    Conserved Domains (1) summary
    cd01611
    Location:13126
    GABARAP; Ubiquitin domain of GABA-receptor-associated protein

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    241407557..241411171 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)