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TRIM67 tripartite motif containing 67 [ Homo sapiens (human) ]

Gene ID: 440730, updated on 8-Aug-2021

Summary

Official Symbol
TRIM67provided by HGNC
Official Full Name
tripartite motif containing 67provided by HGNC
Primary source
HGNC:HGNC:31859
See related
Ensembl:ENSG00000119283 MIM:610584
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TNL
Expression
Biased expression in brain (RPKM 4.1) and adrenal (RPKM 0.2) See more
Orthologs
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Genomic context

See TRIM67 in Genome Data Viewer
Location:
1q42.2
Exon count:
10
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (231162058..231221565)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (231297804..231357311)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr1.12446 Neighboring gene peptidylprolyl isomerase A like 4C pseudogene Neighboring gene TRIM67 antisense RNA 1 Neighboring gene chromosome 1 open reading frame 131 Neighboring gene glyceronephosphate O-acyltransferase Neighboring gene uncharacterized LOC112268256

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ44831

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tripartite motif-containing protein 67
Names
TRIM9-like protein TNL

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004342.5NP_001004342.3  tripartite motif-containing protein 67 isoform 1

    See identical proteins and their annotated locations for NP_001004342.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL109810, AL137801
    Consensus CDS
    CCDS44333.1
    UniProtKB/Swiss-Prot
    Q6ZTA4
    Related
    ENSP00000355613.5, ENST00000366653.6
    Conserved Domains (5) summary
    smart00502
    Location:347473
    BBC; B-Box C-terminal domain
    cd00063
    Location:528604
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00643
    Location:301340
    zf-B_box; B-box zinc finger
    cd12889
    Location:601772
    SPRY_PRY_TRIM67_9; PRY/SPRY domain in tripartite motif-containing proteins, TRIM9 and TRIM67
    cl17238
    Location:745
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
  2. NM_001300889.3NP_001287818.1  tripartite motif-containing protein 67 isoform 2

    See identical proteins and their annotated locations for NP_001287818.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two alternate in-frame segments in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AL109810, AL137801
    Consensus CDS
    CCDS73048.1
    UniProtKB/Swiss-Prot
    Q6ZTA4
    Related
    ENSP00000400163.3, ENST00000449018.7
    Conserved Domains (5) summary
    smart00502
    Location:285411
    BBC; B-Box C-terminal domain
    cd00063
    Location:466542
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00643
    Location:239278
    zf-B_box; B-box zinc finger
    cd12889
    Location:539710
    SPRY_PRY_TRIM67_9; PRY/SPRY domain in tripartite motif-containing proteins, TRIM9 and TRIM67
    cl17238
    Location:730
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    231162058..231221565
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544192.3XP_011542494.1  tripartite motif-containing protein 67 isoform X2

    UniProtKB/TrEMBL
    F8W8C1
    Related
    ENSP00000412124.3, ENST00000444294.7
    Conserved Domains (5) summary
    smart00502
    Location:347473
    BBC; B-Box C-terminal domain
    cd00063
    Location:526602
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00643
    Location:301340
    zf-B_box; B-box zinc finger
    cd12889
    Location:599770
    SPRY_PRY_TRIM67_9; PRY/SPRY domain in tripartite motif-containing proteins, TRIM9 and TRIM67
    cl17238
    Location:745
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
  2. XM_017001323.2XP_016856812.1  tripartite motif-containing protein 67 isoform X1

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