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Ran Ran [ Drosophila melanogaster (fruit fly) ]

Gene ID: 44072, updated on 8-Feb-2025

Summary

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Official Symbol
Ranprovided by FlyBase
Official Full Name
Ranprovided by FlyBase
Primary source
FLYBASE:FBgn0020255
Locus tag
Dmel_CG1404
See related
AllianceGenome:FB:FBgn0020255
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
AAF30287; CG1404; Dmel\CG1404; dran; l(1)G0075; Q9VZ23; ran; RAN; ran10A; RanGTP
Summary
Enables GTP binding activity. Involved in several processes, including microtubule cytoskeleton organization; nuclear pore complex assembly; and regulation of mitotic cell cycle. Located in cell cortex; mitotic spindle microtubule; and nucleus. Colocalizes with mitotic spindle. Is expressed in several structures, including CNS glial cell; embryonic/larval midgut primordium; ganglia; gut section; and head epidermis primordium. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human RAN (RAN, member RAS oncogene family). [provided by Alliance of Genome Resources, Feb 2025]
Orthologs
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Genomic context

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See Ran in Genome Data Viewer
Location:
10A8-10A8; 1-33 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11144852..11148716, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11038885..11042749, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene l(3)mbt interacting protein 1 Neighboring gene retroactive Neighboring gene Dynein light intermediate chain Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Analysis of Ran related to pesticide resistance in Drosophila Kc cells. Bo Q, et al. Gene, 2018 Jul 15. PMID 29680247
  2. RanBP1 Couples Nuclear Export and Golgi Regulation through LKB1 to Promote Cortical Neuron Polarity. Mencarelli C, et al. Cell Rep, 2018 Sep 4. PMID 30184488, Free PMC Article
  3. Involvement of Ran in the regulation of phagocytosis against virus infection in S2 cells. Ye T, et al. Dev Comp Immunol, 2013 Dec. PMID 23916491
  4. Altered nuclear transport and the most selfish of genes. Hawley RS. Dev Cell, 2001 Sep. PMID 11702939
  5. Up-regulated expression of Ran reveals its potential role to deltamethrin stress in Kc cells. Liu W, et al. Gene, 2016 May 25. PMID 26924245

See all (120) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TNPO2 variants associate with human developmental delays, neurologic deficits, and dysmorphic features and alter TNPO2 activity in Drosophila.
    Title: TNPO2 variants associate with human developmental delays, neurologic deficits, and dysmorphic features and alter TNPO2 activity in Drosophila.
  2. Results demonstrate that Ran is associated with the resistance to and tolerance of multiple pesticides.
    Title: Analysis of Ran related to pesticide resistance in Drosophila Kc cells.
  3. RanGTP is required for meiotic spindle organization and the initiation of embryonic development.
    Title: RanGTP is required for meiotic spindle organization and the initiation of embryonic development in Drosophila.
  4. the Canoe Ras-association (RA) domains directly bind RanGTP
    Title: Canoe binds RanGTP to promote Pins(TPR)/Mud-mediated spindle orientation.
  5. Knockdown of the small G protein Ran, which is essential for nuclear transport, leads to an arrest of EcR in the cytoplasm, but does not prevent efficient nuclear import of the most important heterodimerization partner of EcR, ultraspiracle (Usp).
    Title: The importance of exportin and Ran for nucleocytoplasmic shuttling of the ecdysteroid receptor.
  6. the possibility that Dntf-2r and ran-like might be involved in genomic conflicts during spermatogenesis
    Title: Convergently recruited nuclear transport retrogenes are male biased in expression and evolving under positive selection in Drosophila.
  7. results demonstrate that distinctly from its role in spindle assembly, RanGTP maintains spindle microtubules in anaphase through the local activation of ISWI and that this is essential for proper chromosome segregation
    Title: ISWI is a RanGTP-dependent MAP required for chromosome segregation.
  8. anillin and Peanut are involved in pseudocleavage furrow ingression in syncytial embryos, a process that is regulated by Ran
    Title: Anillin-mediated targeting of peanut to pseudocleavage furrows is regulated by the GTPase Ran.
  9. gtpase ran localizes around the microtubule spindle in vivo during mitosis in Drosophila embryos
    Title: Ran localizes around the microtubule spindle in vivo during mitosis in Drosophila embryos.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GTP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in establishment of mitotic spindle orientation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in establishment of mitotic spindle orientation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular protein transport TAS
Traceable Author Statement
more info
 PubMed 
involved_in meiotic spindle organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nuclear pore complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleocytoplasmic transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein export from nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of mitotic cell cycle IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosomal subunit export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with mitotic spindle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitotic spindle microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Ran
Names
CG1404-PA
CG1404-PB
CG1404-PC
CG1404-PD
Ran GTPase
Ran-PA
Ran-PB
Ran-PC
Ran-PD
ran

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    11144852..11148716 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298182.1 → NP_001285111.1  Ran, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285111.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9NH14, Q9NHN9, Q9VZ23
    UniProtKB/TrEMBL
    A4V4A5
    Conserved Domains (1) summary
    PTZ00132
    Location:2 → 216
    PTZ00132; GTP-binding nuclear protein Ran; Provisional

  2. NM_143712.4 → NP_651969.1  Ran, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651969.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9NH14, Q9NHN9, Q9VZ23
    UniProtKB/TrEMBL
    A4V4A5
    Related
    FBpp0073328
    Conserved Domains (1) summary
    PTZ00132
    Location:2 → 216
    PTZ00132; GTP-binding nuclear protein Ran; Provisional

  3. NM_001298183.1 → NP_001285112.1  Ran, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285112.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9NH14, Q9NHN9, Q9VZ23
    UniProtKB/TrEMBL
    A4V4A5
    Conserved Domains (1) summary
    PTZ00132
    Location:2 → 216
    PTZ00132; GTP-binding nuclear protein Ran; Provisional

  4. NM_167272.3 → NP_727499.1  Ran, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727499.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9NH14, Q9NHN9, Q9VZ23
    UniProtKB/TrEMBL
    A4V4A5
    Related
    FBpp0073327
    Conserved Domains (1) summary
    PTZ00132
    Location:2 → 216
    PTZ00132; GTP-binding nuclear protein Ran; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A4V4A5 A4V4A5
Q9VZ23.1 Q9VZ23

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