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ETV3L ETS variant transcription factor 3 like [ Homo sapiens (human) ]

Gene ID: 440695, updated on 9-Jun-2025
Official Symbol
ETV3Lprovided by HGNC
Official Full Name
ETS variant transcription factor 3 likeprovided by HGNC
Primary source
HGNC:HGNC:33834
See related
Ensembl:ENSG00000253831 MIM:621105; AllianceGenome:HGNC:33834
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in cell differentiation and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jun 2025]
Expression
Low expression observed in reference dataset See more
Orthologs
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See ETV3L in Genome Data Viewer
Location:
1q23.1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (157092043..157099808, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (156228899..156236665, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (157061835..157069600, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene MPRA-validated peak427 silencer Neighboring gene SMU1 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:157044311-157044941 Neighboring gene keratin 8 pseudogene 45 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:157059291-157059812 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:157075101-157076062 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1886 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:157082931-157083555 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:157083556-157084181 Neighboring gene ETS variant transcription factor 3 Neighboring gene CYCS pseudogene 52 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:157107959-157108294 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:157108646-157109251 Neighboring gene Sharpr-MPRA regulatory region 11922 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:157127246-157127757 Neighboring gene Sharpr-MPRA regulatory region 527 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:157142571-157143072 Neighboring gene uncharacterized LOC107985211 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1887

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

EBI GWAS Catalog

Description
Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study.
EBI GWAS Catalog
Products Interactant Other Gene Complex Source Pubs Description

Clone Names

  • FLJ16478

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
ETS translocation variant 3-like protein
Names
ETS variant 3 like
ets variant 3-like
ets variant gene 3-like

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004341.2NP_001004341.1  ETS translocation variant 3-like protein

    See identical proteins and their annotated locations for NP_001004341.1

    Status: VALIDATED

    Source sequence(s)
    AA723297, AK131392, AL157713
    Consensus CDS
    CCDS30893.1
    UniProtKB/Swiss-Prot
    Q6ZN32
    Related
    ENSP00000430271.1, ENST00000454449.3
    Conserved Domains (1) summary
    smart00413
    Location:38124
    ETS; erythroblast transformation specific domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    157092043..157099808 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    156228899..156236665 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)