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ETV3L ETS variant transcription factor 3 like [ Homo sapiens (human) ]

Gene ID: 440695, updated on 13-May-2022

Summary

Official Symbol
ETV3Lprovided by HGNC
Official Full Name
ETS variant transcription factor 3 likeprovided by HGNC
Primary source
HGNC:HGNC:33834
See related
Ensembl:ENSG00000253831 AllianceGenome:HGNC:33834
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in cell differentiation and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See ETV3L in Genome Data Viewer
Location:
1q23.1
Exon count:
5
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (157092043..157099808, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (156228899..156236665, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (157061835..157069600, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene SMU1 pseudogene 1 Neighboring gene keratin 8 pseudogene 45 Neighboring gene ETS variant transcription factor 3 Neighboring gene CYCS pseudogene 52 Neighboring gene Sharpr-MPRA regulatory region 11922

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • FLJ16478

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ETS translocation variant 3-like protein
Names
ETS variant 3 like
ets variant 3-like
ets variant gene 3-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004341.2NP_001004341.1  ETS translocation variant 3-like protein

    See identical proteins and their annotated locations for NP_001004341.1

    Status: VALIDATED

    Source sequence(s)
    AA723297, AK131392, AL157713
    Consensus CDS
    CCDS30893.1
    UniProtKB/Swiss-Prot
    Q6ZN32
    Related
    ENSP00000430271.1, ENST00000454449.3
    Conserved Domains (1) summary
    smart00413
    Location:38124
    ETS; erythroblast transformation specific domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    157092043..157099808 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    156228899..156236665 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)