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H3-7 H3.7 histone (putative) [ Homo sapiens (human) ]

Gene ID: 440686, updated on 5-Jul-2025
Official Symbol
H3-7provided by HGNC
Official Full Name
H3.7 histone (putative)provided by HGNC
Primary source
HGNC:HGNC:32060
See related
Ensembl:ENSG00000273213 AllianceGenome:HGNC:32060
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p06; H3-2; H3.7; HIST2H3PS2
Summary
Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is a member of the H3 family, but is found outside of the histone cluster. There is evidence that it is transcribed and has an intact CDS, but residue changes in the protein suggest that it may be on its way to becoming a psuedogene. [provided by RefSeq, Aug 2019]
Orthologs
all
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See H3-7 in Genome Data Viewer
Location:
1q21.1
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (143902386..143905977, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (142974405..142977996, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (149396962..149400553, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene tRNA-Arg (anticodon CCT) 7-1 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:149362195-149362753 Neighboring gene H2B histone pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1255 Neighboring gene Fc gamma receptor Ic, pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr1:149396107-149396742 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:149398885-149399385 Neighboring gene uncharacterized LOC105371209 Neighboring gene ribosomal protein L22 pseudogene 5 Neighboring gene family with sequence similarity 72 member C Neighboring gene SLIT-ROBO Rho GTPase activating protein 2D (pseudogene)

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Crystal Structure and Characterization of Novel Human Histone H3 Variants, H3.6, H3.7, and H3.8. Taguchi H, et al. Biochemistry, 2017 Apr 25. PMID 28374988
  2. Human spleen histone H3. Isolation and amino acid sequence. Ohe Y, et al. J Biochem, 1981 Oct. PMID 7309716
  3. Modifications of human histone H3 variants during mitosis. Garcia BA, et al. Biochemistry, 2005 Oct 4. PMID 16185088
  4. Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks. Huyen Y, et al. Nature, 2004 Nov 18. PMID 15525939
  5. Coactivator-associated arginine methyltransferase-1 enhances nuclear factor-kappaB-mediated gene transcription through methylation of histone H3 at arginine 17. Miao F, et al. Mol Endocrinol, 2006 Jul. PMID 16497732

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Homology

Clone Names

  • MGC126031

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of chromatin IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of nucleosome IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
histone H3-7
Names
H3.2 histone (putative)
histone 2, H3, pseudogene 2
histone H3.2
histone HIST2H3PS2
histone cluster 2 H3 pseudogene 2

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355409.3 → NP_001342338.1  histone H3-7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents a spliced variant and is thought to represent a minor form.
    Source sequence(s)
    AC239798
    Consensus CDS
    CCDS30842.1
    UniProtKB/Swiss-Prot
    Q5TEC6
    UniProtKB/TrEMBL
    A8K4Y7, B2R6Y1
    Related
    ENSP00000499501.1, ENST00000609879.2
    Conserved Domains (1) summary
    PTZ00018
    Location:1 → 136
    PTZ00018; histone H3; Provisional

  2. NM_001372105.2 → NP_001359034.1  histone H3-7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents an intronless transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC239798
    Consensus CDS
    CCDS30842.1
    UniProtKB/Swiss-Prot
    Q5TEC6
    UniProtKB/TrEMBL
    A8K4Y7, B2R6Y1
    Related
    ENSP00000476960.1, ENST00000392948.5
    Conserved Domains (1) summary
    PTZ00018
    Location:1 → 136
    PTZ00018; histone H3; Provisional

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    143902386..143905977 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    142974405..142977996 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_012783.2: Suppressed sequence

    Description
    NG_012783.2: This RefSeq was removed because it is now thought that this locus is a transcribed gene.

  2. NM_001025303.1: Suppressed sequence

    Description
    NM_001025303.1: This RefSeq was permanently suppressed because it is now thought that this gene is a pseudogene.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5TEC6.1 GenPept UniProtKB/Swiss-Prot:Q5TEC6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials