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H3-2 H3.2 histone (putative) [ Homo sapiens (human) ]

Gene ID: 440686, updated on 20-Jul-2021

Summary

Official Symbol
H3-2provided by HGNC
Official Full Name
H3.2 histone (putative)provided by HGNC
Primary source
HGNC:HGNC:32060
See related
Ensembl:ENSG00000273213
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p06; H3.7; HIST2H3PS2
Summary
Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is a member of the H3 family, but is found outside of the histone cluster. There is evidence that it is transcribed and has an intact CDS, but residue changes in the protein suggest that it may be on its way to becoming a psuedogene. [provided by RefSeq, Aug 2019]
Orthologs
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Genomic context

See H3-2 in Genome Data Viewer
Location:
1q21.1
Exon count:
2
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (143902386..143905977, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (149396962..149400553, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene tRNA-Arg (anticodon CCT) 7-1 Neighboring gene H2B histone pseudogene 2 Neighboring gene Fc fragment of IgG receptor Ic, pseudogene Neighboring gene uncharacterized LOC105371209 Neighboring gene ribosomal protein L22 pseudogene 5 Neighboring gene family with sequence similarity 72 member C Neighboring gene SLIT-ROBO Rho GTPase activating protein 2D (pseudogene)

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • MGC126031

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of nucleosome IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
histone HIST2H3PS2
Names
histone 2, H3, pseudogene 2
histone H3.2
histone cluster 2 H3 pseudogene 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355409.3NP_001342338.1  histone HIST2H3PS2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents a spliced variant and is thought to represent a minor form.
    Source sequence(s)
    AC239798
    Related
    ENSP00000499501.1, ENST00000609879.2
    Conserved Domains (1) summary
    PTZ00018
    Location:1136
    PTZ00018; histone H3; Provisional
  2. NM_001372105.2NP_001359034.1  histone HIST2H3PS2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents an intronless transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC239798
    Related
    ENSP00000476960.1, ENST00000392948.5
    Conserved Domains (1) summary
    PTZ00018
    Location:1136
    PTZ00018; histone H3; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    143902386..143905977 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_012783.2: Suppressed sequence

    Description
    NG_012783.2: This RefSeq was removed because it is now thought that this locus is a transcribed gene.
  2. NM_001025303.1: Suppressed sequence

    Description
    NM_001025303.1: This RefSeq was permanently suppressed because it is now thought that this gene is a pseudogene.
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