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NUDT4B nudix hydrolase 4B [ Homo sapiens (human) ]

Gene ID: 440672, updated on 5-Aug-2022

Summary

Official Symbol
NUDT4Bprovided by HGNC
Official Full Name
nudix hydrolase 4Bprovided by HGNC
Primary source
HGNC:HGNC:18012
See related
Ensembl:ENSG00000177144 AllianceGenome:HGNC:18012
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DIPP-2B; NUDT4P1
Summary
Predicted to enable pyrophosphatase activity. Predicted to be involved in diphosphoinositol polyphosphate metabolic process and nucleotide catabolic process. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See NUDT4B in Genome Data Viewer
Location:
1q21.2
Exon count:
1
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (148748774..148752415)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (146035500..146039137, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 (PATCHES) NW_003871055.3 (5564187..5567828)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371222 Neighboring gene RNA, U6 small nuclear 1171, pseudogene Neighboring gene SEC22 homolog B3, pseudogene Neighboring gene phosphodiesterase 4D interacting protein Neighboring gene RN7SK pseudogene 88

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ23763

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables bis(5'-adenosyl)-hexaphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables bis(5'-adenosyl)-pentaphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables diphosphoinositol-polyphosphate diphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables endopolyphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables m7G(5')pppN diphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in adenosine 5'-(hexahydrogen pentaphosphate) catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in diadenosine hexaphosphate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in diadenosine pentaphosphate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in diphosphoinositol polyphosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
diphosphoinositol polyphosphate phosphohydrolase NUDT4B
Names
nucleoside diphosphate-linked moiety X motif 4B
nudix (nucleoside diphosphate linked moiety X)-type motif 4 pseudogene 1
nudix motif 4B
NP_001342336.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355407.2NP_001342336.1  diphosphoinositol polyphosphate phosphohydrolase NUDT4B

    Status: VALIDATED

    Source sequence(s)
    AC245389
    Consensus CDS
    CCDS86013.1
    UniProtKB/Swiss-Prot
    A0A024RBG1
    Related
    ENSP00000492425.1, ENST00000322209.5
    Conserved Domains (1) summary
    cd04666
    Location:19138
    Nudix_Hydrolase_9; Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    148748774..148752415
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    146035500..146039137 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)