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ZYG11A zyg-11 family member A, cell cycle regulator [ Homo sapiens (human) ]

Gene ID: 440590, updated on 23-Nov-2021

Summary

Official Symbol
ZYG11Aprovided by HGNC
Official Full Name
zyg-11 family member A, cell cycle regulatorprovided by HGNC
Primary source
HGNC:HGNC:32058
See related
Ensembl:ENSG00000203995 MIM:618675
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZYG11
Expression
Biased expression in testis (RPKM 2.3), thyroid (RPKM 1.5) and 6 other tissues See more
Orthologs
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Genomic context

See ZYG11A in Genome Data Viewer
Location:
1p32.3
Exon count:
15
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (52842736..52894998)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (53308432..53360670)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene zyg-11 family member B, cell cycle regulator Neighboring gene RNA, U6 small nuclear 969, pseudogene Neighboring gene Sharpr-MPRA regulatory region 11599 Neighboring gene Sharpr-MPRA regulatory region 4702 Neighboring gene enoyl-CoA hydratase domain containing 2 Neighboring gene translation machinery-associated protein 7 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
part_of Cul2-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
protein zyg-11 homolog A
Names
ZYG-11A early embryogenesis protein
zyg-11 homolog A

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004339.3NP_001004339.2  protein zyg-11 homolog A isoform 1

    See identical proteins and their annotated locations for NP_001004339.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC099677, AI638616, AY271826, BC119815
    Consensus CDS
    CCDS44148.1
    UniProtKB/Swiss-Prot
    Q6WRX3
    Related
    ENSP00000360583.1, ENST00000371528.2
    Conserved Domains (3) summary
    cd00020
    Location:511629
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    cd00116
    Location:195314
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00034
    Location:158182
    LRR_AMN1; leucine-rich repeat [structural motif]
  2. NM_001307931.2NP_001294860.1  protein zyg-11 homolog A isoform 2

    See identical proteins and their annotated locations for NP_001294860.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' coding region compared to variant 1. This variant represents translation initiation at a downstream AUG compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream AUG to encode an isoform (2) that has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC099677, AI638616, AY271826, BC119815
    Consensus CDS
    CCDS76166.1
    UniProtKB/Swiss-Prot
    Q6WRX3
    Related
    ENSP00000360587.1, ENST00000371532.5
    Conserved Domains (2) summary
    cd00020
    Location:169287
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    cl21453
    Location:32132
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    52842736..52894998
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541482.3XP_011539784.1  protein zyg-11 homolog A isoform X3

    Conserved Domains (4) summary
    cd00020
    Location:511584
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    cd00116
    Location:195314
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00034
    Location:158182
    LRR_AMN1; leucine-rich repeat [structural motif]
    cl21453
    Location:374474
    PKc_like; Protein Kinases, catalytic domain
  2. XM_011541480.3XP_011539782.1  protein zyg-11 homolog A isoform X1

    Conserved Domains (3) summary
    cd00020
    Location:511614
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    cd00116
    Location:195314
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00034
    Location:158182
    LRR_AMN1; leucine-rich repeat [structural motif]
  3. XM_011541483.3XP_011539785.1  protein zyg-11 homolog A isoform X4

    Conserved Domains (4) summary
    cd00020
    Location:511660
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    cd00116
    Location:195314
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00034
    Location:158182
    LRR_AMN1; leucine-rich repeat [structural motif]
    cl21453
    Location:374474
    PKc_like; Protein Kinases, catalytic domain
  4. XM_011541481.3XP_011539783.1  protein zyg-11 homolog A isoform X2

    Conserved Domains (3) summary
    cd00020
    Location:452570
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    cd00116
    Location:195314
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00034
    Location:158182
    LRR_AMN1; leucine-rich repeat [structural motif]
  5. XM_011541484.1XP_011539786.1  protein zyg-11 homolog A isoform X5

    Conserved Domains (4) summary
    cd00020
    Location:511629
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    cd00116
    Location:195314
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00034
    Location:158182
    LRR_AMN1; leucine-rich repeat [structural motif]
    cl21453
    Location:374474
    PKc_like; Protein Kinases, catalytic domain
  6. XM_011541485.1XP_011539787.1  protein zyg-11 homolog A isoform X6

    Conserved Domains (3) summary
    cd00116
    Location:195314
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00034
    Location:158182
    LRR_AMN1; leucine-rich repeat [structural motif]
    cl21453
    Location:374474
    PKc_like; Protein Kinases, catalytic domain
  7. XM_011541486.1XP_011539788.1  protein zyg-11 homolog A isoform X7

    Conserved Domains (3) summary
    cd00116
    Location:195314
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00034
    Location:158182
    LRR_AMN1; leucine-rich repeat [structural motif]
    cl21453
    Location:374474
    PKc_like; Protein Kinases, catalytic domain
  8. XM_011541487.2XP_011539789.1  protein zyg-11 homolog A isoform X8

    Conserved Domains (3) summary
    cd00116
    Location:195314
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00034
    Location:158182
    LRR_AMN1; leucine-rich repeat [structural motif]
    cl21453
    Location:374474
    PKc_like; Protein Kinases, catalytic domain
  9. XM_011541488.1XP_011539790.1  protein zyg-11 homolog A isoform X9

    Conserved Domains (2) summary
    cd00116
    Location:195314
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00034
    Location:207232
    LRR_AMN1; leucine-rich repeat [structural motif]
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