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FAM183A family with sequence similarity 183 member A [ Homo sapiens (human) ]

Gene ID: 440585, updated on 5-Jan-2022

Summary

Official Symbol
FAM183Aprovided by HGNC
Official Full Name
family with sequence similarity 183 member Aprovided by HGNC
Primary source
HGNC:HGNC:34347
See related
Ensembl:ENSG00000186973
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to be located in centrosome and ciliary basal body. Predicted to be active in ciliary base. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in skin (RPKM 1.4), lung (RPKM 1.0) and 5 other tissues See more
Orthologs
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Genomic context

See FAM183A in Genome Data Viewer
Location:
1p34.2
Exon count:
5
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (43142959..43156396)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (43613575..43622067)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 880, pseudogene Neighboring gene Sharpr-MPRA regulatory region 10275 Neighboring gene uncharacterized LOC105378685 Neighboring gene EBNA1 binding protein 2 Neighboring gene microRNA 6733 Neighboring gene cilia and flagella associated protein 57 Neighboring gene RNA, 5S ribosomal pseudogene 46

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of family with sequence similarity 183, member A (FAM183A) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
is_active_in ciliary base IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
protein FAM183A
Names
hCG23177

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001101376.3NP_001094846.2  protein FAM183A

    See identical proteins and their annotated locations for NP_001094846.2

    Status: VALIDATED

    Source sequence(s)
    AI192630, AI375550, AL139138
    Consensus CDS
    CCDS44126.1
    UniProtKB/Swiss-Prot
    A6NL82
    Related
    ENSP00000334415.3, ENST00000335282.5
    Conserved Domains (1) summary
    pfam14886
    Location:19121
    FAM183; FAM183A and FAM183B related

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    43142959..43156396
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005270876.4XP_005270933.1  protein FAM183A isoform X2

    Related
    ENSP00000387249.1, ENST00000410048.5
    Conserved Domains (1) summary
    pfam14886
    Location:17109
    FAM183; FAM183A and FAM183B related
  2. XM_017001322.1XP_016856811.1  protein FAM183A isoform X2

    Conserved Domains (1) summary
    pfam14886
    Location:17109
    FAM183; FAM183A and FAM183B related
  3. XM_005270875.5XP_005270932.1  protein FAM183A isoform X1

    See identical proteins and their annotated locations for XP_005270932.1

    Related
    ENSP00000387254.1, ENST00000409396.5
    Conserved Domains (1) summary
    pfam14886
    Location:19137
    FAM183; FAM183A and FAM183B related
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