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MICOS10 mitochondrial contact site and cristae organizing system subunit 10 [ Homo sapiens (human) ]

Gene ID: 440574, updated on 7-Jun-2020

Summary

Official Symbol
MICOS10provided by HGNC
Official Full Name
mitochondrial contact site and cristae organizing system subunit 10provided by HGNC
Primary source
HGNC:HGNC:32068
See related
Ensembl:ENSG00000173436 MIM:616574
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIO10; Mic10; MINOS1; C1orf151
Expression
Ubiquitous expression in colon (RPKM 13.8), kidney (RPKM 11.9) and 25 other tissues See more
Orthologs

Genomic context

See MICOS10 in Genome Data Viewer
Location:
1p36.13
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (19596977..19629821)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (19923471..19956315)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376819 Neighboring gene uncharacterized LOC105376817 Neighboring gene uncharacterized LOC105378614 Neighboring gene MICOS10-NBL1 readthrough Neighboring gene ribosomal protein S14 pseudogene 3 Neighboring gene NBL1, DAN family BMP antagonist Neighboring gene 5-hydroxytryptamine receptor 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies a novel susceptibility gene for serum TSH levels in Chinese populations.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ36999, FLJ75158

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
inner mitochondrial membrane organization IC
Inferred by Curator
more info
PubMed 

General protein information

Preferred Names
MICOS complex subunit MIC10
Names
RP5-1056L3.2
UPF0327 protein C1orf151
mitochondrial inner membrane organizing system 1
mitochondrial inner membrane organizing system protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001032363.4NP_001027535.1  MICOS complex subunit MIC10 isoform a

    See identical proteins and their annotated locations for NP_001027535.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform a.
    Source sequence(s)
    AL031727, BC070388, DA523181, DB323148
    Consensus CDS
    CCDS30620.1
    UniProtKB/Swiss-Prot
    Q5TGZ0
    Related
    ENSP00000325562.6, ENST00000322753.7
    Conserved Domains (1) summary
    pfam04418
    Location:262
    DUF543; Domain of unknown function (DUF543)
  2. NM_001204082.1NP_001191011.1  MICOS complex subunit MIC10 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon in the coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a.
    Source sequence(s)
    AL031727, BM784596, DA523181, DB323148
    Consensus CDS
    CCDS72719.1
    UniProtKB/TrEMBL
    A0A087WU07
    Related
    ENSP00000478278.1, ENST00000617872.4
    Conserved Domains (1) summary
    pfam04418
    Location:246
    DUF543; Domain of unknown function (DUF543)
  3. NM_001204083.2NP_001191012.1  MICOS complex subunit MIC10 isoform c

    See identical proteins and their annotated locations for NP_001191012.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) contains an alternate exon in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform c, which is longer and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AL031727, CB157536, DA523181, DB323148
    Conserved Domains (1) summary
    pfam04418
    Location:162
    DUF543; Domain of unknown function (DUF543)

RNA

  1. NR_033757.3 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an additional internal exon, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL031727, DA523181, DA793500, DB323148
  2. NR_033758.3 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) includes an additional internal exon, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL031727, BC009927, DA523181, DB323148

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    19596977..19629821
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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