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PRAMEF6 PRAME family member 6 [ Homo sapiens (human) ]

Gene ID: 440561, updated on 5-Aug-2022

Summary

Official Symbol
PRAMEF6provided by HGNC
Official Full Name
PRAME family member 6provided by HGNC
Primary source
HGNC:HGNC:30583
See related
Ensembl:ENSG00000232423 AllianceGenome:HGNC:30583
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables ubiquitin ligase-substrate adaptor activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Part of Cul2-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
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Genomic context

See PRAMEF6 in Genome Data Viewer
Location:
1p36.21
Exon count:
4
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (12938472..12947580, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (12482394..12489336, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (12998302..13007406, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 1072, pseudogene Neighboring gene PRAME family member 29, pseudogene Neighboring gene PRAME family member 28, pseudogene Neighboring gene PRAME family member 27

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001010889.2NP_001010889.1  PRAME family member 6

    See identical proteins and their annotated locations for NP_001010889.1

    Status: VALIDATED

    Source sequence(s)
    AL358783, BC101342
    Consensus CDS
    CCDS30594.1
    UniProtKB/Swiss-Prot
    A0AUJ9, Q5VXH4
    Related
    ENSP00000365360.1, ENST00000376189.5

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    12938472..12947580 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_012132914.1 Reference GRCh38.p14 PATCHES

    Range
    119985..129093 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    12482394..12489336 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)