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ZNF506 zinc finger protein 506 [ Homo sapiens (human) ]

Gene ID: 440515, updated on 12-Oct-2019

Summary

Official Symbol
ZNF506provided by HGNC
Official Full Name
zinc finger protein 506provided by HGNC
Primary source
HGNC:HGNC:23780
See related
Ensembl:ENSG00000081665
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in thyroid (RPKM 8.8), lymph node (RPKM 4.7) and 25 other tissues See more
Orthologs

Genomic context

See ZNF506 in Genome Data Viewer
Location:
19p13.11
Exon count:
4
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (19792711..19821750, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (19896648..19932560, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101060187 Neighboring gene sorting nexin 18 pseudogene Neighboring gene long intergenic non-protein coding RNA 663 Neighboring gene uncharacterized LOC112267872 Neighboring gene zinc finger protein 56 Neighboring gene iron-sulfur cluster assembly 1 pseudogene 5 Neighboring gene BCL2 interacting protein 3 pseudogene 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from BioSystems

  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC27136, DKFZp761G1812

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleolus IDA
Inferred from Direct Assay
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099269.3NP_001092739.1  zinc finger protein 506 isoform 1

    See identical proteins and their annotated locations for NP_001092739.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC011477, AI559570, AK095575, DA122515
    Consensus CDS
    CCDS42531.1
    UniProtKB/Swiss-Prot
    Q5JVG8
    Related
    ENSP00000440625.1, ENST00000540806.7
    Conserved Domains (5) summary
    smart00349
    Location:462
    KRAB; krueppel associated box
    COG5048
    Location:255417
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:259279
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:643
    KRAB; KRAB box
    pfam13465
    Location:215240
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001145404.2NP_001138876.1  zinc finger protein 506 isoform 2

    See identical proteins and their annotated locations for NP_001138876.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AC011477, AI559570, AK095575, AK122848
    Consensus CDS
    CCDS46027.1
    UniProtKB/Swiss-Prot
    Q5JVG8
    Related
    ENSP00000408892.1, ENST00000450683.6
    Conserved Domains (5) summary
    smart00349
    Location:443
    KRAB; krueppel associated box
    COG5048
    Location:223385
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:227247
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:643
    KRAB; KRAB box
    pfam13465
    Location:183208
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    19792711..19821750 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001145405.1: Suppressed sequence

    Description
    NM_001145405.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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