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PLIN5 perilipin 5 [ Homo sapiens (human) ]

Gene ID: 440503, updated on 2-Oct-2022

Summary

Official Symbol
PLIN5provided by HGNC
Official Full Name
perilipin 5provided by HGNC
Primary source
HGNC:HGNC:33196
See related
Ensembl:ENSG00000214456 MIM:613248; AllianceGenome:HGNC:33196
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MLDP; LSDA5; LSDP5; OXPAT
Summary
Members of the perilipin family, such as PLIN5, coat intracellular lipid storage droplets and protect them from lipolytic degradation (Dalen et al., 2007 [PubMed 17234449]).[supplied by OMIM, Feb 2010]
Expression
Biased expression in fat (RPKM 26.3), ovary (RPKM 14.4) and 10 other tissues See more
Orthologs
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Genomic context

See PLIN5 in Genome Data Viewer
Location:
19p13.3
Exon count:
8
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (4522531..4535224, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (4506212..4518891, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (4522543..4535236, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene chromatin assembly factor 1 subunit A Neighboring gene microRNA 4746 Neighboring gene UBX domain protein 6 Neighboring gene HDGF like 2 Neighboring gene perilipin 4 Neighboring gene leucine rich alpha-2-glycoprotein 1 Neighboring gene semaphorin 6B Neighboring gene Sharpr-MPRA regulatory region 7851

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: LRG1

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables lipase binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in lipid droplet organization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in lipid storage IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitochondrion localization IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of fatty acid beta-oxidation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of lipase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of peroxisome proliferator activated receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of reactive oxygen species metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of triglyceride catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of fatty acid beta-oxidation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of lipase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of lipid storage ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of sequestering of triglyceride IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of sequestering of triglyceride ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of triglyceride biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
is_active_in lipid droplet IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in lipid droplet IDA
Inferred from Direct Assay
more info
 
colocalizes_with lipid droplet ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
perilipin-5
Names
lipid storage droplet protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013706.3NP_001013728.2  perilipin-5

    See identical proteins and their annotated locations for NP_001013728.2

    Status: VALIDATED

    Source sequence(s)
    AC011498, AW445065, BC033570, BX105717, DQ839131
    Consensus CDS
    CCDS42473.1
    UniProtKB/Swiss-Prot
    Q00G26, Q6ZS68
    Related
    ENSP00000371272.2, ENST00000381848.7
    Conserved Domains (1) summary
    pfam03036
    Location:16368
    Perilipin; Perilipin family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    4522531..4535224 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    4506212..4518891 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)