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PLIN5 perilipin 5 [ Homo sapiens (human) ]

Gene ID: 440503, updated on 24-Nov-2020

Summary

Official Symbol
PLIN5provided by HGNC
Official Full Name
perilipin 5provided by HGNC
Primary source
HGNC:HGNC:33196
See related
Ensembl:ENSG00000214456 MIM:613248
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MLDP; LSDA5; LSDP5; OXPAT
Summary
Members of the perilipin family, such as PLIN5, coat intracellular lipid storage droplets and protect them from lipolytic degradation (Dalen et al., 2007 [PubMed 17234449]).[supplied by OMIM, Feb 2010]
Expression
Biased expression in fat (RPKM 26.3), ovary (RPKM 14.4) and 10 other tissues See more
Orthologs

Genomic context

See PLIN5 in Genome Data Viewer
Location:
19p13.3
Exon count:
8
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (4522531..4535224, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (4522543..4535208, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene chromatin assembly factor 1 subunit A Neighboring gene microRNA 4746 Neighboring gene UBX domain protein 6 Neighboring gene HDGF like 2 Neighboring gene perilipin 4 Neighboring gene leucine rich alpha-2-glycoprotein 1 Neighboring gene semaphorin 6B Neighboring gene uncharacterized LOC105372249

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: LRG1

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
lipase binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
lipid droplet organization ISS
Inferred from Sequence or Structural Similarity
more info
 
lipid storage IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion localization IEA
Inferred from Electronic Annotation
more info
 
negative regulation of fatty acid beta-oxidation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of lipase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of peroxisome proliferator activated receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of reactive oxygen species metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of triglyceride catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of fatty acid beta-oxidation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of lipase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of lipid storage ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of sequestering of triglyceride IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of sequestering of triglyceride ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of triglyceride biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
lipid droplet IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lipid droplet IDA
Inferred from Direct Assay
more info
 
colocalizes_with lipid droplet ISS
Inferred from Sequence or Structural Similarity
more info
 
mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
perilipin-5
Names
lipid storage droplet protein 5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013706.3NP_001013728.2  perilipin-5

    See identical proteins and their annotated locations for NP_001013728.2

    Status: VALIDATED

    Source sequence(s)
    AC011498, AW445065, BC033570, BX105717, DQ839131
    Consensus CDS
    CCDS42473.1
    UniProtKB/Swiss-Prot
    Q00G26
    Related
    ENSP00000371272.2, ENST00000381848.7
    Conserved Domains (1) summary
    pfam03036
    Location:16368
    Perilipin; Perilipin family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    4522531..4535224 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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