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GPR179 G protein-coupled receptor 179 [ Homo sapiens (human) ]

Gene ID: 440435, updated on 2-Oct-2018

Summary

Official Symbol
GPR179provided by HGNC
Official Full Name
G protein-coupled receptor 179provided by HGNC
Primary source
HGNC:HGNC:31371
See related
Ensembl:ENSG00000277399 MIM:614515; Vega:OTTHUMG00000188545
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CSNB1E; GPR158L; GPR158L1
Summary
This gene encodes a member of the glutamate receptor subfamily of G protein-coupled receptors. The encoded protein has an EGF-like calcium binding domain and a seven transmembrane domain in the N-terminal region of the protein. Mutations in this gene are associated with congenital stationary night blindness type 1E. [provided by RefSeq, Apr 2012]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See GPR179 in Genome Data Viewer
Location:
17q12
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (38325610..38343810, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (36481493..36499693, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371760 Neighboring gene mitochondrial ribosomal protein L45 Neighboring gene suppressor of cytokine signaling 7 Neighboring gene Rho GTPase activating protein 23 Neighboring gene uncharacterized LOC101929494

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Congenital stationary night blindness, type 1E
MedGen: C3281215 OMIM: 614565 GeneReviews: Not available
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NHGRI GWAS Catalog

Description
GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.
NHGRI GWA Catalog

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
visual perception IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
probable G-protein coupled receptor 179
Names
GPR158-like 1
probable G-protein coupled receptor 158-like 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032655.2 RefSeqGene

    Range
    5001..23201
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001004334.3NP_001004334.3  probable G-protein coupled receptor 179 precursor

    Status: REVIEWED

    Source sequence(s)
    AC244092, AY584611
    Consensus CDS
    CCDS42308.1
    UniProtKB/Swiss-Prot
    Q6PRD1
    UniProtKB/TrEMBL
    A0A087X0K8
    Related
    ENSP00000483469.1, OTTHUMP00000276829, ENST00000616987.4, OTTHUMT00000477586
    Conserved Domains (2) summary
    cd00054
    Location:278327
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam00003
    Location:392632
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    38325610..38343810 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_1

Genomic

  1. NT_187614.1 Reference GRCh38.p12 ALT_REF_LOCI_1

    Range
    2360558..2378758 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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