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RNASEK ribonuclease K [ Homo sapiens (human) ]

Gene ID: 440400, updated on 7-Jun-2020

Summary

Official Symbol
RNASEKprovided by HGNC
Official Full Name
ribonuclease Kprovided by HGNC
Primary source
HGNC:HGNC:33911
See related
Ensembl:ENSG00000219200 MIM:617098
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in adrenal (RPKM 84.0), kidney (RPKM 67.2) and 25 other tissues See more
Orthologs

Genomic context

See RNASEK in Genome Data Viewer
Location:
17p13.1
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (7012417..7014533)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (6915736..6917852)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene Spi-C transcription factor (Spi-1/PU.1 related) pseudogene Neighboring gene ALOX12 antisense RNA 1 Neighboring gene arachidonate 12-lipoxygenase, 12S type Neighboring gene RNASEK-C17orf49 readthrough Neighboring gene chromosome 17 open reading frame 49 Neighboring gene mir-497-195 cluster host gene Neighboring gene microRNA 195

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough RNASEK-C17orf49

Readthrough gene: RNASEK-C17orf49, Included gene: C17orf49

Homology

Clone Names

  • MGC48891, MGC71993

Gene Ontology Provided by GOA

Function Evidence Code Pubs
endoribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoribonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
RNA phosphodiester bond hydrolysis, endonucleolytic IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ribonuclease kappa
Names
RNase kappa
RNase kappa-02 isoform
ribonuclease, RNase K
NP_001004333.3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004333.5NP_001004333.3  ribonuclease kappa

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the supported protein.
    Source sequence(s)
    AC040977
    Consensus CDS
    CCDS45594.2
    Related
    ENSP00000449500.1, ENST00000548577.5

RNA

  1. NR_037715.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an additional internal exon, compared to variant 1. This variant is represented as non-coding because the use of the expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA633512, AC040977, BC070349, BM835723, BQ223829, CD176288
    Related
    ENST00000546395.5
  2. NR_037716.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5'-most exon, compared to variant 1. This variant is represented as non-coding because the use of the expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA633512, AC040977, BC070349, BC095436, BM835723, CD176288

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    7012417..7014533
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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