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RNASEK ribonuclease K [ Homo sapiens (human) ]

Gene ID: 440400, updated on 26-Oct-2022

Summary

Official Symbol
RNASEKprovided by HGNC
Official Full Name
ribonuclease Kprovided by HGNC
Primary source
HGNC:HGNC:33911
See related
Ensembl:ENSG00000219200 MIM:617098; AllianceGenome:HGNC:33911
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables endoribonuclease activity. Predicted to be involved in RNA phosphodiester bond hydrolysis, endonucleolytic. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal (RPKM 84.0), kidney (RPKM 67.2) and 25 other tissues See more
Orthologs
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Genomic context

See RNASEK in Genome Data Viewer
Location:
17p13.1
Exon count:
4
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (7012624..7014532)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (6913249..6915130)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (6915943..6917851)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903906 Neighboring gene ALOX12 antisense RNA 1 Neighboring gene arachidonate 12-lipoxygenase, 12S type Neighboring gene RNASEK-C17orf49 readthrough Neighboring gene chromosome 17 open reading frame 49 Neighboring gene mir-497-195 cluster host gene Neighboring gene microRNA 195

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough RNASEK-C17orf49

Readthrough gene: RNASEK-C17orf49, Included gene: C17orf49

Homology

Clone Names

  • MGC48891, MGC71993

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables endoribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables endoribonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in clathrin-coated vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
located_in endomembrane system IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of proton-transporting V-type ATPase complex IC
Inferred by Curator
more info
PubMed 
part_of vacuolar proton-transporting V-type ATPase, V0 domain ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
ribonuclease kappa
Names
RNase kappa
V-ATPase subunit f
V-type proton ATPase subunit f
ribonuclease, RNase K
NP_001004333.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004333.5NP_001004333.3  ribonuclease kappa

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the supported protein.
    Source sequence(s)
    AC040977
    Consensus CDS
    CCDS45594.3
    UniProtKB/TrEMBL
    A0A0C4DH89
    Related
    ENSP00000468923.2, ENST00000593646.6

RNA

  1. NR_037715.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an additional internal exon, compared to variant 1. This variant is represented as non-coding because the use of the expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA633512, BC070349, BM835723, BQ223829, CD176288
    Related
    ENST00000549393.2
  2. NR_037716.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5'-most exon, compared to variant 1. This variant is represented as non-coding because the use of the expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA633512, BC070349, BC095436, BM835723, CD176288
    Related
    ENST00000552039.2

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    7012624..7014532
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    6913249..6915130
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)