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SMIM22 small integral membrane protein 22 [ Homo sapiens (human) ]

Gene ID: 440335, updated on 5-Jan-2022

Summary

Official Symbol
SMIM22provided by HGNC
Official Full Name
small integral membrane protein 22provided by HGNC
Primary source
HGNC:HGNC:48329
See related
Ensembl:ENSG00000267795
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CASIMO1
Summary
Involved in several processes, including lipid droplet formation; positive regulation of cell migration; and regulation of actin cytoskeleton organization. Predicted to be located in late endosome. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in colon (RPKM 25.1), stomach (RPKM 16.4) and 10 other tissues See more
Orthologs
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Genomic context

See SMIM22 in Genome Data Viewer
Location:
16p13.3
Exon count:
7
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (4788395..4796491)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (4838398..4846492)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and sterile alpha motif domain containing 3 Neighboring gene Sharpr-MPRA regulatory region 8628 Neighboring gene dynein axonemal assembly factor 8 Neighboring gene zinc finger protein 500 Neighboring gene septin 12 Neighboring gene Sharpr-MPRA regulatory region 4562 Neighboring gene rogdi atypical leucine zipper Neighboring gene glyoxylate reductase 1 homolog

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in late endosome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
small integral membrane protein 22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001253790.1NP_001240719.1  small integral membrane protein 22 isoform 1

    See identical proteins and their annotated locations for NP_001240719.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform (1). Both variants 1 and 3 encode the same isoform (1).
    Source sequence(s)
    BC035868, CK903133
    Consensus CDS
    CCDS59258.1
    UniProtKB/TrEMBL
    A0A1U9AC72
    Related
    ENSP00000465660.1, ENST00000589721.5
    Conserved Domains (1) summary
    cd20255
    Location:683
    CASIMO1_SMIM22; small integral membrane protein 22 (SMIM22) of CASIMO1
  2. NM_001253791.1NP_001240720.1  small integral membrane protein 22 isoform 2

    See identical proteins and their annotated locations for NP_001240720.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a longer protein (isoform 2), compared to isoform 1. Both variants 2 and 4 encode the same isoform (2).
    Source sequence(s)
    BC048326, CK903133
    Consensus CDS
    CCDS59259.1
    UniProtKB/Swiss-Prot
    K7EJ46
    Related
    ENSP00000468237.1, ENST00000589327.5
    Conserved Domains (1) summary
    cd20255
    Location:688
    CASIMO1_SMIM22; small integral membrane protein 22 (SMIM22) of CASIMO1
  3. NM_001253793.2NP_001240722.1  small integral membrane protein 22 isoform 1

    See identical proteins and their annotated locations for NP_001240722.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Both variants 1 and 3 encode the same isoform (1).
    Source sequence(s)
    AC020663, BI767985, CK903133
    Consensus CDS
    CCDS59258.1
    UniProtKB/TrEMBL
    A0A1U9AC72
    Related
    ENSP00000464737.1, ENST00000588606.5
    Conserved Domains (1) summary
    cd20255
    Location:683
    CASIMO1_SMIM22; small integral membrane protein 22 (SMIM22) of CASIMO1
  4. NM_001253794.2NP_001240723.1  small integral membrane protein 22 isoform 2

    See identical proteins and their annotated locations for NP_001240723.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a longer protein (isoform 2), compared to isoform 1. Both variants 2 and 4 encode the same isoform (2).
    Source sequence(s)
    AA507469, AC020663, BI767985, CK903133
    Consensus CDS
    CCDS59259.1
    UniProtKB/Swiss-Prot
    K7EJ46
    Related
    ENSP00000464748.1, ENST00000586005.6
    Conserved Domains (1) summary
    cd20255
    Location:688
    CASIMO1_SMIM22; small integral membrane protein 22 (SMIM22) of CASIMO1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    4788395..4796491
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522500.2XP_011520802.1  small integral membrane protein 22 isoform X1

    See identical proteins and their annotated locations for XP_011520802.1

    UniProtKB/Swiss-Prot
    K7EJ46
    Conserved Domains (1) summary
    cd20255
    Location:688
    CASIMO1_SMIM22; small integral membrane protein 22 (SMIM22) of CASIMO1
  2. XM_011522499.2XP_011520801.1  small integral membrane protein 22 isoform X1

    See identical proteins and their annotated locations for XP_011520801.1

    UniProtKB/Swiss-Prot
    K7EJ46
    Related
    ENSP00000481592.1, ENST00000615889.4
    Conserved Domains (1) summary
    cd20255
    Location:688
    CASIMO1_SMIM22; small integral membrane protein 22 (SMIM22) of CASIMO1
  3. XM_011522501.2XP_011520803.1  small integral membrane protein 22 isoform X1

    See identical proteins and their annotated locations for XP_011520803.1

    UniProtKB/Swiss-Prot
    K7EJ46
    Conserved Domains (1) summary
    cd20255
    Location:688
    CASIMO1_SMIM22; small integral membrane protein 22 (SMIM22) of CASIMO1
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