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TTLL13 tubulin tyrosine ligase like 13 [ Homo sapiens (human) ]

Gene ID: 440307, updated on 2-Nov-2024

Summary

Official Symbol
TTLL13provided by HGNC
Official Full Name
tubulin tyrosine ligase like 13provided by HGNC
Primary source
HGNC:HGNC:32484
See related
Ensembl:ENSG00000213471 MIM:620485; AllianceGenome:HGNC:32484
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TTLL13P
Summary
Predicted to enable tubulin binding activity and tubulin-glutamic acid ligase activity. Predicted to be involved in microtubule cytoskeleton organization. Predicted to be located in cytosol. Predicted to be active in cilium. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward testis (RPKM 11.1) See more
Orthologs
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Genomic context

See TTLL13 in Genome Data Viewer
Location:
15q26.1
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (90249556..90265477)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (88005550..88021467)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (90792788..90808709)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene semaphorin 4B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10068 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr15:90754487-90755686 Neighboring gene ribosomal protein S12 pseudogene 26 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:90755750-90755924 Neighboring gene Sharpr-MPRA regulatory region 13535 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:90764595-90765433 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6817 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6818 Neighboring gene calcium and integrin binding 1 Neighboring gene GDP-D-glucose phosphorylase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10069 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10070 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:90807916-90808887 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:90808888-90809858 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:90818447-90819000 Neighboring gene neugrin, neurite outgrowth associated Neighboring gene PERP pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: NGRN

Clone Names

  • FLJ46079, MGC33417

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables tubulin-glutamic acid ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables tubulin-glutamic acid ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables tubulin-glutamic acid ligase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
involved_in microtubule bundle formation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein modification process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in ciliary basal body IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tubulin polyglutamylase TTLL13
Names
tubulin polyglutamylase TTLL13P
tubulin tyrosine ligase like 13, pseudogene
tubulin tyrosine ligase-like family, member 13
tubulin--tyrosine ligase-like protein 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001396017.1NP_001382946.1  tubulin polyglutamylase TTLL13

    Status: VALIDATED

    Source sequence(s)
    AC091167
    Consensus CDS
    CCDS92063.1
    UniProtKB/Swiss-Prot
    A6NNM8
    UniProtKB/TrEMBL
    A0A286YFC2
    Related
    ENSP00000493387.1, ENST00000641754.2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    90249556..90265477
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    88005550..88021467
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001029964.2: Suppressed sequence

    Description
    NM_001029964.2: This RefSeq was permanently suppressed because it is now thought that this gene is a pseudogene.