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SMCO3 single-pass membrane protein with coiled-coil domains 3 [ Homo sapiens (human) ]

Gene ID: 440087, updated on 1-Jun-2020

Summary

Official Symbol
SMCO3provided by HGNC
Official Full Name
single-pass membrane protein with coiled-coil domains 3provided by HGNC
Primary source
HGNC:HGNC:34401
See related
Ensembl:ENSG00000179256
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C12orf69
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See SMCO3 in Genome Data Viewer
Location:
12p12.3
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (14804650..14816761, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (14957584..14967116, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene chromosome 12 open reading frame 60 Neighboring gene H2A.J histone Neighboring gene WW domain binding protein 11 Neighboring gene ADP-ribosyltransferase 4 (Dombrock blood group) Neighboring gene matrix Gla protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
single-pass membrane and coiled-coil domain-containing protein 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013698.2NP_001013720.2  single-pass membrane and coiled-coil domain-containing protein 3

    See identical proteins and their annotated locations for NP_001013720.2

    Status: VALIDATED

    Source sequence(s)
    AK092637, BM696674, BU735185
    Consensus CDS
    CCDS41759.1
    UniProtKB/Swiss-Prot
    A2RU48
    Related
    ENSP00000381895.1, ENST00000316048.2
    Conserved Domains (1) summary
    pfam15047
    Location:15221
    DUF4533; Protein of unknown function (DUF4533)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    14804650..14816761 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017019312.1XP_016874801.1  single-pass membrane and coiled-coil domain-containing protein 3 isoform X1

    UniProtKB/Swiss-Prot
    A2RU48
    Conserved Domains (1) summary
    pfam15047
    Location:15221
    DUF4533; Protein of unknown function (DUF4533)
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