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DDX12P DEAD/H-box helicase 12, pseudogene [ Homo sapiens (human) ]

Gene ID: 440081, updated on 3-May-2025
Official Symbol
DDX12Pprovided by HGNC
Official Full Name
DEAD/H-box helicase 12, pseudogeneprovided by HGNC
Primary source
HGNC:HGNC:2737
See related
MIM:601151; AllianceGenome:HGNC:2737
Gene type
pseudo
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CHLR2; DDX12
Summary
Predicted to enable DNA helicase activity. Predicted to be involved in establishment of sister chromatid cohesion. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, May 2025]
Expression
Broad expression in bone marrow (RPKM 14.1), lymph node (RPKM 7.1) and 25 other tissues See more
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See DDX12P in Genome Data Viewer
Location:
12p13.31
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (9417691..9448172, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (9400442..9430908, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (9570287..9600768, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2367 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:9555514-9556155 Neighboring gene ovostatin homolog 2 Neighboring gene uncharacterized LOC105369647 Neighboring gene uncharacterized LOC124902873 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:9590133-9590632 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4227 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:9600631-9600851 Neighboring gene alpha-2-macroglobulin like 1 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4228 Neighboring gene RAN binding protein 6 pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:9721455-9722278 Neighboring gene killer cell lectin like receptor B1

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Warsaw Breakage Syndrome associated DDX11 helicase resolves G-quadruplex structures to support sister chromatid cohesion. van Schie JJM, et al. Nat Commun, 2020 Aug 27. PMID 32855419, Free PMC Article
  2. Localization of chi1-related helicase genes to human chromosome regions 12p11 and 12p13: similarity between parts of these genes and conserved human telomeric-associated DNA. Amann J, et al. Genomics, 1996 Mar 1. PMID 8833153
  3. Characterization of putative human homologues of the yeast chromosome transmission fidelity gene, CHL1. Amann J, et al. J Biol Chem, 1997 Feb 7. PMID 9013641
  4. Lineage-specific gene duplication and loss in human and great ape evolution. Fortna A, et al. PLoS Biol, 2004 Jul. PMID 15252450, Free PMC Article
  5. C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains. Jülg J, et al. EMBO Rep, 2023 Aug 3. PMID 37317656, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Review eQTL and phenotype association data in this region using PheGenI

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Other Names

  • CHL1-like helicase homolog 2
  • CHL1-related protein 2
  • DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 12 (CHL1-like helicase homolog, S. cerevisiae)
  • DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 12, pseudogene
  • DEAD/H box protein 12
  • DEAD/H box-12
  • hCHLR2
  • probable ATP-dependent RNA helicase DDX12

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides IEA
Inferred from Electronic Annotation
more info
  
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in establishment of sister chromatid cohesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleobase-containing compound metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_033399.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC092821, AC141557

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    9417691..9448172 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    9400442..9430908 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_004400.1: Suppressed sequence

    Description
    NM_004400.1: This RefSeq was permanently suppressed because it is now thought that this gene is a pseudogene.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q92771.3 GenPept UniProtKB/Swiss-Prot:Q92771

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials