IFIT1B interferon induced protein with tetratricopeptide repeats 1B [Homo sapiens (human)] - Gene

Summary

Official Symbol: IFIT1Bprovided by HGNC
Official Full Name: interferon induced protein with tetratricopeptide repeats 1Bprovided by HGNC
Primary source: HGNC:HGNC:23442
See related: Ensembl:ENSG00000204010 AllianceGenome:HGNC:23442
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: IFIT1L; bA149I23.6
Summary: Predicted to enable RNA binding activity. Predicted to be involved in defense response to virus. Predicted to act upstream of or within cellular response to interferon-alpha; cellular response to interferon-beta; and response to bacterium. Predicted to be located in cytoplasm. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward bone marrow (RPKM 10.2) See more
Orthologs: all
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Genomic context

Location:: 10q23.31

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
110	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (89378056..89385205)
110	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (90261914..90269063)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (91137813..91144962)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Homologs of the IFIT1B gene: The IFIT1B gene is conserved in Rhesus monkey, mouse, and rat.
Orthologs from Annotation Pipeline: 29 organisms have orthologs with human gene IFIT1B
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to exogenous dsRNA	IEA Inferred from Electronic Annotation more info
involved_in cellular response to type I interferon	IEA Inferred from Electronic Annotation more info
involved_in defense response to virus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in regulation of defense response to virus	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

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Preferred Names: interferon-induced protein with tetratricopeptide repeats 1B

Names: interferon-induced protein with tetratricopeptide repeats 1-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001010987.2 → NP_001010987.1 interferon-induced protein with tetratricopeptide repeats 1B

See identical proteins and their annotated locations for NP_001010987.1

Status: VALIDATED

Source sequence(s)

AL353751

Consensus CDS

CCDS31242.1

UniProtKB/Swiss-Prot

A7E245, Q5T764

Related

ENSP00000360874.3, ENST00000371809.3

Conserved Domains (2) summary

sd00006
Location:251 → 279

TPR; TPR repeat [structural motif]

cl26002
Location:36 → 298

TPR_11; TPR repeat