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IFIT1B interferon induced protein with tetratricopeptide repeats 1B [ Homo sapiens (human) ]

Gene ID: 439996, updated on 12-Jun-2025
Official Symbol
IFIT1Bprovided by HGNC
Official Full Name
interferon induced protein with tetratricopeptide repeats 1Bprovided by HGNC
Primary source
HGNC:HGNC:23442
See related
Ensembl:ENSG00000204010 AllianceGenome:HGNC:23442
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IFIT1L; bA149I23.6
Summary
Predicted to enable RNA binding activity. Predicted to be involved in defense response to virus. Predicted to act upstream of or within cellular response to interferon-alpha; cellular response to interferon-beta; and response to bacterium. Predicted to be located in cytoplasm. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Jun 2025]
Expression
Restricted expression toward bone marrow (RPKM 10.2) See more
Orthologs
all
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See IFIT1B in Genome Data Viewer
Location:
10q23.31
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (89378056..89385205)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (90261914..90269063)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (91137813..91144962)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2592 Neighboring gene Sharpr-MPRA regulatory region 6014 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3743 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3744 Neighboring gene interferon induced protein with tetratricopeptide repeats 3 Neighboring gene lipase A, lysosomal acid type Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3745 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3746 Neighboring gene interferon induced protein with tetratricopeptide repeats 6, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr10:91151215-91151376 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3747 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3748 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3749 Neighboring gene interferon induced protein with tetratricopeptide repeats 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3750 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3751 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3752 Neighboring gene lipase A, lysosomal acid type Neighboring gene interferon induced protein with tetratricopeptide repeats 5

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Evolution-guided functional analyses reveal diverse antiviral specificities encoded by IFIT1 genes in mammals. Daugherty MD, et al. Elife, 2016 May 31. PMID 27240734, Free PMC Article
  2. Cloning and chromosomal location of human genes inducible by type I interferon. Wathelet MG, et al. Somat Cell Mol Genet, 1988 Sep. PMID 3175763
  3. The broad-spectrum antiviral functions of IFIT and IFITM proteins. Diamond MS, et al. Nat Rev Immunol, 2013 Jan. PMID 23237964, Free PMC Article
  4. IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA. Pichlmair A, et al. Nat Immunol, 2011 Jun 5. PMID 21642987
  5. Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins. Yang J, et al. Cell Rep, 2023 Feb 28. PMID 36724073

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • DKFZp781M1841

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT enables RNA sequestering activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in defense response to virus IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT involved_in negative regulation of viral translation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to other organism IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
interferon-induced protein with tetratricopeptide repeats 1B
Names
interferon-induced protein with tetratricopeptide repeats 1-like protein

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001010987.2 → NP_001010987.1  interferon-induced protein with tetratricopeptide repeats 1B

    See identical proteins and their annotated locations for NP_001010987.1

    Status: VALIDATED

    Source sequence(s)
    AL353751
    Consensus CDS
    CCDS31242.1
    UniProtKB/Swiss-Prot
    A7E245, Q5T764
    Related
    ENSP00000360874.3, ENST00000371809.3
    Conserved Domains (2) summary
    sd00006
    Location:251 → 279
    TPR; TPR repeat [structural motif]
    cl26002
    Location:36 → 298
    TPR_11; TPR repeat

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    89378056..89385205
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    90261914..90269063
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5T764.1 GenPept UniProtKB/Swiss-Prot:Q5T764

Gene LinkOut

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