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IFIT1B interferon induced protein with tetratricopeptide repeats 1B [ Homo sapiens (human) ]

Gene ID: 439996, updated on 23-Nov-2023

Summary

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Official Symbol
IFIT1Bprovided by HGNC
Official Full Name
interferon induced protein with tetratricopeptide repeats 1Bprovided by HGNC
Primary source
HGNC:HGNC:23442
See related
Ensembl:ENSG00000204010 AllianceGenome:HGNC:23442
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IFIT1L; bA149I23.6
Summary
Predicted to enable RNA binding activity. Predicted to be involved in defense response to virus. Predicted to act upstream of or within cellular response to interferon-alpha; cellular response to interferon-beta; and response to bacterium. Predicted to be located in cytoplasm. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward bone marrow (RPKM 10.2) See more
Orthologs
all
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Genomic context

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See IFIT1B in Genome Data Viewer
Location:
10q23.31
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (89378056..89385205)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (90261914..90269063)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (91137813..91144962)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101926887 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2592 Neighboring gene Sharpr-MPRA regulatory region 6014 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3743 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3744 Neighboring gene interferon induced protein with tetratricopeptide repeats 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3745 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3746 Neighboring gene interferon induced protein with tetratricopeptide repeats 6, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr10:91151215-91151376 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3747 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3748 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3749 Neighboring gene interferon induced protein with tetratricopeptide repeats 1 Neighboring gene uncharacterized LOC107984251 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3750 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3751 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3752 Neighboring gene interferon induced protein with tetratricopeptide repeats 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Cloning and chromosomal location of human genes inducible by type I interferon. Wathelet MG, et al. Somat Cell Mol Genet, 1988 Sep. PMID 3175763
  2. The broad-spectrum antiviral functions of IFIT and IFITM proteins. Diamond MS, et al. Nat Rev Immunol, 2013 Jan. PMID 23237964, Free PMC Article
  3. IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA. Pichlmair A, et al. Nat Immunol, 2011 Jun 5. PMID 21642987
  4. Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins. Yang J, et al. Cell Rep, 2023 Feb 28. PMID 36724073
  5. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp781M1841

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in defense response to virus IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
interferon-induced protein with tetratricopeptide repeats 1B
Names
interferon-induced protein with tetratricopeptide repeats 1-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001010987.2 → NP_001010987.1  interferon-induced protein with tetratricopeptide repeats 1B

    See identical proteins and their annotated locations for NP_001010987.1

    Status: VALIDATED

    Source sequence(s)
    AL353751
    Consensus CDS
    CCDS31242.1
    UniProtKB/Swiss-Prot
    A7E245, Q5T764
    Related
    ENSP00000360874.3, ENST00000371809.3
    Conserved Domains (2) summary
    sd00006
    Location:251 → 279
    TPR; TPR repeat [structural motif]
    cl26002
    Location:36 → 298
    TPR_11; TPR repeat

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    89378056..89385205
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    90261914..90269063
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5T764.1 GenPept UniProtKB/Swiss-Prot:Q5T764

Gene LinkOut

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