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Pten Phosphatase and tensin homolog [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43991, updated on 8-Oct-2017
Official Symbol
Ptenprovided by FlyBase
Official Full Name
Phosphatase and tensin homologprovided by FlyBase
Primary source
FLYBASE:FBgn0026379
Locus tag
Dmel_CG5671
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster (old-lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5671; Dmel\CG5671; dpten; dPten; dPTEN; DPTEN; pten; PTEN; PTEN3
Location:
31B1-31B1
Exon count:
13
Annotation release Status Assembly Chr Location
Release 6.13 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10256319..10261049, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10256319..10261049, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene CG31717 gene product from transcript CG31717-RA Neighboring gene CG4926 gene product from transcript CG4926-RA Neighboring gene CG5676 gene product from transcript CG5676-RA Neighboring gene Repressor splicing factor 1 Neighboring gene REPTOR-binding partner

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
PDZ domain binding ISS
Inferred from Sequence or Structural Similarity
more info
 
actin binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
non-membrane spanning protein tyrosine phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
phosphatidylinositol-3-phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
phosphoprotein phosphatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphoprotein phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
protein serine/threonine phosphatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein serine/threonine phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein tyrosine phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein tyrosine/serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
protein tyrosine/serine/threonine phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
protein tyrosine/serine/threonine phosphatase activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
animal organ morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
apoptotic process TAS
Traceable Author Statement
more info
PubMed 
autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
basement membrane organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell competition in a multicellular organism IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular process IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
dendrite regeneration IMP
Inferred from Mutant Phenotype
more info
PubMed 
epithelial cell fate determination, open tracheal system IMP
Inferred from Mutant Phenotype
more info
PubMed 
inositol phosphate dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
insulin receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
insulin receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
larval development IMP
Inferred from Mutant Phenotype
more info
PubMed 
larval midgut histolysis IGI
Inferred from Genetic Interaction
more info
PubMed 
larval salivary gland morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
lipid homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
lipid storage IMP
Inferred from Mutant Phenotype
more info
PubMed 
melanotic encapsulation of foreign target IMP
Inferred from Mutant Phenotype
more info
PubMed 
metamorphosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of axon regeneration IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell cycle TAS
Traceable Author Statement
more info
PubMed 
negative regulation of cell growth NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cell size TAS
Traceable Author Statement
more info
PubMed 
negative regulation of focal adhesion assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of growth TAS
Traceable Author Statement
more info
PubMed 
negative regulation of insulin receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of insulin receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
negative regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of organ growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of organ growth NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of organ growth TAS
Traceable Author Statement
more info
PubMed 
negative regulation of protein kinase B signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
neuron remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
ovarian follicle cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphatidylinositol dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol dephosphorylation NAS
Non-traceable Author Statement
more info
PubMed 
phosphatidylinositol dephosphorylation TAS
Traceable Author Statement
more info
PubMed 
protein dephosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
protein dephosphorylation NAS
Non-traceable Author Statement
more info
PubMed 
protein kinase B signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell junction assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell shape IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell size IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell size NAS
Non-traceable Author Statement
more info
PubMed 
regulation of dendrite development IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of establishment of planar polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of hemocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of multicellular organism growth NAS
Non-traceable Author Statement
more info
PubMed 
regulation of organ growth NAS
Non-traceable Author Statement
more info
PubMed 
regulation of protein stability ISS
Inferred from Sequence or Structural Similarity
more info
 
response to starvation IMP
Inferred from Mutant Phenotype
more info
PubMed 
rhabdomere development IMP
Inferred from Mutant Phenotype
more info
PubMed 
somatic muscle development IMP
Inferred from Mutant Phenotype
more info
PubMed 
tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
CG5671 gene product from transcript CG5671-RB
Names
CG5671-PA
CG5671-PB
CG5671-PC
CG5671-PD
CG5671-PE
CG5671-PG
CG5671-PH
PI 3-phosphatase
PTEN
PtdIns(3,4,5)P3 phosphatase
Pten-PA
Pten-PB
Pten-PC
Pten-PD
Pten-PE
Pten-PG
Pten-PH
drosophila phosphatase and tensin homologue deleted on chromosome 10
phosphatase and tensin homolog
phosphatase and tensin homologue
phosphatidylinositol (3,4,5)-trisphosphate phosphatase
NP_001162933.1
NP_477422.2
NP_477423.1
NP_477424.1
NP_599147.1
NP_599148.1
NP_599149.1

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    10256319..10261049 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058075.4NP_477423.1  phosphatase and tensin homolog, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477423.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KMQ6
    Related
    FBpp0088843.1, FBtr0089904
    Conserved Domains (2) summary
    pfam10409
    Location:196335
    PTEN_C2; C2 domain of PTEN tumour-suppressor protein
    cl21483
    Location:58167
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  2. NM_134320.3NP_599147.1  phosphatase and tensin homolog, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_599147.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9V3L4
    Related
    FBpp0088844.1, FBtr0089905
    Conserved Domains (2) summary
    pfam10409
    Location:196335
    PTEN_C2; C2 domain of PTEN tumour-suppressor protein
    cl21483
    Location:58167
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  3. NM_058074.4NP_477422.2  phosphatase and tensin homolog, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477422.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KMQ6
    Related
    FBpp0290736.1, FBtr0301521
    Conserved Domains (2) summary
    pfam10409
    Location:196335
    PTEN_C2; C2 domain of PTEN tumour-suppressor protein
    cl21483
    Location:58167
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  4. NM_058076.4NP_477424.1  phosphatase and tensin homolog, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477424.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9Y0B6
    Related
    FBpp0088841.1, FBtr0089902
    Conserved Domains (2) summary
    pfam10409
    Location:196335
    PTEN_C2; C2 domain of PTEN tumour-suppressor protein
    cl21483
    Location:58167
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  5. NM_134322.3NP_599149.1  phosphatase and tensin homolog, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_599149.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KMQ6
    Related
    FBpp0088839.1, FBtr0089900
    Conserved Domains (2) summary
    pfam10409
    Location:196335
    PTEN_C2; C2 domain of PTEN tumour-suppressor protein
    cl21483
    Location:58167
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  6. NM_134321.3NP_599148.1  phosphatase and tensin homolog, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_599148.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9V3L4
    Related
    FBpp0088840.1, FBtr0089901
    Conserved Domains (2) summary
    pfam10409
    Location:196335
    PTEN_C2; C2 domain of PTEN tumour-suppressor protein
    cl21483
    Location:58167
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  7. NM_001169462.2NP_001162933.1  phosphatase and tensin homolog, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162933.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KMQ6
    Related
    FBpp0289789.1, FBtr0300562
    Conserved Domains (2) summary
    pfam10409
    Location:196335
    PTEN_C2; C2 domain of PTEN tumour-suppressor protein
    cl21483
    Location:58167
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
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