Gk1 Glycerol kinase 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Gk1provided by FlyBase
Official Full Name: Glycerol kinase 1provided by FlyBase
Primary source: FLYBASE:FBgn0025592
Locus tag: Dmel_CG18374
See related: AllianceGenome:FB:FBgn0025592
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG18374; dGyk; Dmel\CG18374; Gyk
Summary: Enables glycerol kinase activity. Involved in glycerol-3-phosphate biosynthetic process. Predicted to be located in cytosol and nucleus. Predicted to be active in mitochondrion. Is expressed in several structures, including adult head; embryonic/larval midgut; embryonic/larval midgut primordium; and spermatozoon. Used to study glycerol kinase deficiency. Human ortholog(s) of this gene implicated in glycerol kinase deficiency. Orthologous to several human genes including GK2 (glycerol kinase 2) and GK3 (glycerol kinase 3). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Genomic context

Location:: 61B2-61B2; 3-1 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (202098..205844, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (202098..205844, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pigment-dispersing factor and CCHamide1 in the Drosophila circadian clock network.
Title: Pigment-dispersing factor and CCHamide1 in the Drosophila circadian clock network.
Analysis of the genome of Drosophila melanogaster led to identification of five GK orthologs, including two loci with sequence homology to the mammalian Xp21 GK protein.
Title: Conserved family of glycerol kinase loci in Drosophila melanogaster.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables glycerol kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycerol kinase activity	IEA Inferred from Electronic Annotation more info
enables glycerol kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables glycerol kinase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables phosphotransferase activity, alcohol group as acceptor	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycerol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycerol-3-phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycerol-3-phosphate biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycerol-3-phosphate biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in glycerol-3-phosphate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in triglyceride metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: glycerol kinase 1

Names: CG18374-PA; CG18374-PB; Gk1-PA; Gk1-PB; glycerol kinase

NP_524655.1

EC 2.7.1.-

EC 2.7.1.30

NP_728486.1

EC 2.7.1.-

EC 2.7.1.30

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

202098..205844 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_167803.2 → NP_728486.1 glycerol kinase 1, isoform B

See identical proteins and their annotated locations for NP_728486.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8IGQ5, Q8IRJ9

Related

FBpp0072429

Conserved Domains (2) summary

TIGR01311
Location:1 → 458

glycerol_kin; glycerol kinase

cl17037
Location:1 → 458

NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
NM_079916.3 → NP_524655.1 glycerol kinase 1, isoform A

See identical proteins and their annotated locations for NP_524655.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8IGQ5, Q9W0U0

Related

FBpp0072428

Conserved Domains (2) summary

cd07792
Location:18 → 522

FGGY_GK1-3_metazoa; Metazoan glycerol kinase 1 and 3-like proteins; belongs to the FGGY family of carbohydrate kinases

TIGR01311
Location:18 → 522

glycerol_kin; glycerol kinase