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AMPKalpha AMP-activated protein kinase alpha subunit [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43904, updated on 4-Jan-2025

Summary

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Official Symbol
AMPKalphaprovided by FlyBase
Official Full Name
AMP-activated protein kinase alpha subunitprovided by FlyBase
Primary source
FLYBASE:FBgn0023169
Locus tag
Dmel_CG3051
See related
AllianceGenome:FB:FBgn0023169
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
AK; ampk; Ampk; AMPK; AMPK alpha; AMPK-alpha; ampkalpha; AmpKalpha; CG3051; dAMPK; dAMPKa; dAMPKalpha; DmAMPK alpha; Dmel\CG3051; EG:132E8.2; FBgn0023169; Gprk-4; Gprk4; snf1a; snf1A; SNF1A; SNF4A-a
Summary
Enables AMP-activated protein kinase activity. Involved in several processes, including behavioral response to starvation; negative regulation of cell size; and regulation of TORC1 signaling. Located in basolateral part of cell; endosome; and nucleus. Is expressed in adult head. Used to study Parkinson's disease and obesity. Human ortholog(s) of this gene implicated in Huntington's disease; breast cancer; colon cancer; and type 2 diabetes mellitus. Orthologous to several human genes including PRKAA2 (protein kinase AMP-activated catalytic subunit alpha 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See AMPKalpha in Genome Data Viewer
Location:
2A1-2A1; 1-0.2 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (1375536..1378896)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (1269569..1272929)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene sister-of-Sex-lethal Neighboring gene mir-4961 stem loop Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Rab interacting lysosomal protein like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Activation of AMPK by the putative dietary restriction mimetic metformin is insufficient to extend lifespan in Drosophila. Slack C, et al. PLoS One, 2012. PMID 23077661, Free PMC Article
  2. AMP-activated protein kinase protects against anoxia in Drosophila melanogaster. Evans JJ, et al. Comp Biochem Physiol A Mol Integr Physiol, 2017 Dec. PMID 28916374
  3. An Organelle-Specific Nanozyme for Diabetes Care in Genetically or Diet-Induced Models. Zhou Y, et al. Adv Mater, 2020 Nov. PMID 33015921
  4. The anti-aging effects of Ludwigia octovalvis on Drosophila melanogaster and SAMP8 mice. Lin WS, et al. Age (Dordr), 2014 Apr. PMID 24338263, Free PMC Article
  5. AMPK signaling mediates synphilin-1-induced hyperphagia and obesity in Drosophila. Liu J, et al. J Cell Sci, 2021 Feb 5. PMID 33443093, Free PMC Article

See all (204) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Phosphorylation of LKB1 by PDK1 Inhibits Cell Proliferation and Organ Growth by Decreased Activation of AMPK.
    Title: Phosphorylation of LKB1 by PDK1 Inhibits Cell Proliferation and Organ Growth by Decreased Activation of AMPK.
  2. A conserved role for AMP-activated protein kinase in NGLY1 deficiency.
    Title: A conserved role for AMP-activated protein kinase in NGLY1 deficiency.
  3. Data (including data from transgenic flies) suggest that SNF1A is involved in neuroprotection in this species; AMPK activation in glia (but not neurons) reduces severity of ionic disruption and prolongs recovery of electrical activity in brains of flies in starvation-induced anoxia.
    Title: AMP-activated protein kinase protects against anoxia in Drosophila melanogaster.
  4. AMPK can function outside of its canonical nutrient-sensing role in specific developmental contexts.
    Title: AMP-activated protein kinase has diet-dependent and -independent roles in Drosophila oogenesis.
  5. The significance of these findings is that AMPK is important in the regulation of glucagon signaling, suggesting that the organization of metabolic networks is highly conserved and that AMPK plays a prominent role in these networks.
    Title: Energy-dependent modulation of glucagon-like signaling in Drosophila via the AMP-activated protein kinase.
  6. Loss of AMPK activity exacerbates neuronal loss and associated phenotypes in parkin and LRRK transgenic flies.
    Title: AMP kinase activation mitigates dopaminergic dysfunction and mitochondrial abnormalities in Drosophila models of Parkinson's disease.
  7. Data suggest that that an Sgt1/Hsp90-LKB1-AMPK pathway acts redundantly with a microtubule-induced polarity pathway to generate neuroblast cortical polarity, and the absence of neuroblast cortical polarity can produce neuroblast tumors.
    Title: Sgt1 acts via an LKB1/AMPK pathway to establish cortical polarity in larval neuroblasts.
  8. AMPK gamma and alpha mutants altered lipid metabolism and showed persistent starvation behaviors.
    Title: Altered metabolism and persistent starvation behaviors caused by reduced AMPK function in Drosophila.
  9. AMPK supports growth in Drosophila by regulating muscle activity and nutrient uptake in the gut
    Title: AMPK supports growth in Drosophila by regulating muscle activity and nutrient uptake in the gut.
  10. These results raise the possibility that muscle is one of major tissues in which AMPK plays a critical role on longevity and stress resistance.
    Title: A critical role of SNF1A/dAMPKalpha (Drosophila AMP-activated protein kinase alpha) in muscle on longevity and stress resistance in Drosophila melanogaster.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables AMP-activated protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables AMP-activated protein kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in behavioral response to starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to glucose starvation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment or maintenance of epithelial cell apical/basal polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of TOR signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of TORC1 signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cell size IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of TORC1 signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of autophagosome assembly ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in positive regulation of axon guidance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of lipophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of macroautophagy ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of digestive system process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sequestering of triglyceride IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in basolateral part of cell IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nucleotide-activated protein kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nucleotide-activated protein kinase complex IC
Inferred by Curator
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
AMP-activated protein kinase alpha subunit
Names
AMP activated kinase
AMP-activated kinase
AMP-activated protein kinase
AMP-dependent kinase
AMPK alpha subunit
AMPK catalytic subunit
AMPKalpha-PA
AMPKalpha-PB
AMPKalpha-PC
CG3051-PA
CG3051-PB
CG3051-PC
G protein-coupled receptor kinase 4
SNF1A/AMP-activated protein kinase
adenosine monophosphate-activated protein kinase
NP_477313.1
NP_726730.1
NP_996327.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    1375536..1378896
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_166880.2 → NP_726730.1  AMP-activated protein kinase alpha subunit, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726730.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O18645, Q5U118, Q9U4G0
    Related
    FBpp0070209
    Conserved Domains (3) summary
    cd12122
    Location:457 → 580
    AMPKA_C; C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha catalytic subunit
    cd14336
    Location:297 → 360
    UBA_AID_AMPKalpha; UBA-like autoinhibitory domain (AID) found in vertebrate 5'-AMP-activated protein kinase catalytic alpha (AMPKalpha) subunits
    cd14079
    Location:25 → 280
    STKc_AMPK_alpha; Catalytic domain of the Alpha subunit of the Serine/Threonine Kinase, AMP-activated protein kinase

  2. NM_206604.2 → NP_996327.1  AMP-activated protein kinase alpha subunit, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996327.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O18645, Q5U118, Q9U4G0
    Conserved Domains (3) summary
    cd12122
    Location:457 → 580
    AMPKA_C; C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha catalytic subunit
    cd14336
    Location:297 → 360
    UBA_AID_AMPKalpha; UBA-like autoinhibitory domain (AID) found in vertebrate 5'-AMP-activated protein kinase catalytic alpha (AMPKalpha) subunits
    cd14079
    Location:25 → 280
    STKc_AMPK_alpha; Catalytic domain of the Alpha subunit of the Serine/Threonine Kinase, AMP-activated protein kinase

  3. NM_057965.4 → NP_477313.1  AMP-activated protein kinase alpha subunit, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477313.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O18645, Q5U118, Q9U4G0
    Related
    FBpp0070208
    Conserved Domains (3) summary
    cd12122
    Location:457 → 580
    AMPKA_C; C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha catalytic subunit
    cd14336
    Location:297 → 360
    UBA_AID_AMPKalpha; UBA-like autoinhibitory domain (AID) found in vertebrate 5'-AMP-activated protein kinase catalytic alpha (AMPKalpha) subunits
    cd14079
    Location:25 → 280
    STKc_AMPK_alpha; Catalytic domain of the Alpha subunit of the Serine/Threonine Kinase, AMP-activated protein kinase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O18645 O18645
Q5U118 Q5U118
Q7KK41 Q7KK41

Gene LinkOut

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