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E23 Early gene at 23 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43895, updated on 6-Jul-2026
Official Symbol
E23provided by FlyBase
Official Full Name
Early gene at 23provided by FlyBase
Primary source
FLYBASE:FBgn0020445
Locus tag
Dmel_CG3327
See related
AllianceGenome:FB:FBgn0020445
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG15410; CG3327; DmCG3327; Dmel\CG3327; e23
Summary
Predicted to enable ATPase-coupled transmembrane transporter activity. Involved in regulation of circadian rhythm. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See E23 in Genome Data Viewer
Location:
23E4-23E5; 2-9 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (3334875..3354829, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (3334875..3354829, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene GRAM domain containing 1B

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Nup98-dependent transcriptional memory is established independently of transcription. Pascual-Garcia P, et al. Elife, 2022 Mar 15. PMID 35289742, Free PMC Article
  2. The E23 early gene of Drosophila encodes an ecdysone-inducible ATP-binding cassette transporter capable of repressing ecdysone-mediated gene activation. Hock T, et al. Proc Natl Acad Sci U S A, 2000 Aug 15. PMID 10931948, Free PMC Article
  3. Powerful, efficient QTL mapping in Drosophila melanogaster using bulked phenotyping and pooled sequencing. Macdonald SJ, et al. Genetics, 2022 Mar 3. PMID 35100395, Free PMC Article
  4. Transcriptional induction by ecdysone in Drosophila salivary glands involves an increase in chromatin accessibility and acetylation. Evdokimova AA, et al. Nucleic Acids Res, 2025 Apr 10. PMID 40239993, Free PMC Article
  5. EcR recruits dMi-2 and increases efficiency of dMi-2-mediated remodelling to constrain transcription of hormone-regulated genes. Kreher J, et al. Nat Commun, 2017 Apr 5. PMID 28378812, Free PMC Article

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATPase-coupled transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of circadian rhythm IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of circadian rhythm IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
early gene at 23
Names
CG3327-PC
CG3327-PD
CG3327-PE
E23-PC
E23-PD
E23-PE
NP_524648.3
NP_608768.2
NP_995622.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    3334875..3354829 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079909.3 → NP_524648.3  early gene at 23, isoform D

    See identical proteins and their annotated locations for NP_524648.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    I0C0M7, Q7KU30, Q9GZ10, Q9VQP3, Q9VQP4
    Conserved Domains (3) summary
    cd03213
    Location:350 → 572
    ABCG_EPDR; Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily
    TIGR00955
    Location:363 → 1009
    3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein
    pfam01061
    Location:744 → 943
    ABC2_membrane; ABC-2 type transporter

  2. NM_205900.2 → NP_995622.1  early gene at 23, isoform C

    See identical proteins and their annotated locations for NP_995622.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    I0C0M7, Q7KU30, Q9GZ10, Q9VQP3, Q9VQP4
    Conserved Domains (3) summary
    cd03213
    Location:350 → 572
    ABCG_EPDR; Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily
    TIGR00955
    Location:363 → 1009
    3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein
    pfam01061
    Location:744 → 943
    ABC2_membrane; ABC-2 type transporter

  3. NM_134924.2 → NP_608768.2  early gene at 23, isoform E

    See identical proteins and their annotated locations for NP_608768.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    I0C0M7, Q7KU30, Q9GZ10, Q9VQP3, Q9VQP4
    Conserved Domains (3) summary
    cd03213
    Location:350 → 572
    ABCG_EPDR; Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily
    TIGR00955
    Location:363 → 1009
    3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein
    pfam01061
    Location:744 → 943
    ABC2_membrane; ABC-2 type transporter
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7KU30 Q7KU30
Q7YU52 Q7YU52
Q9GZ10 Q9GZ10

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