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KLK12 kallikrein related peptidase 12 [ Homo sapiens (human) ]

Gene ID: 43849, updated on 23-Nov-2021

Summary

Official Symbol
KLK12provided by HGNC
Official Full Name
kallikrein related peptidase 12provided by HGNC
Primary source
HGNC:HGNC:6360
See related
Ensembl:ENSG00000186474 MIM:605539
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KLKL5; KLK-L5
Summary
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Expression
Biased expression in esophagus (RPKM 4.6), salivary gland (RPKM 1.0) and 4 other tissues See more
Orthologs
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Genomic context

See KLK12 in Genome Data Viewer
Location:
19q13.41
Exon count:
6
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (51028954..51035648, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (51532350..51538258, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene kallikrein related peptidase 10 Neighboring gene kallikrein related peptidase 11 Neighboring gene kallikrein related peptidase 13 Neighboring gene uncharacterized LOC107985341

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated 2021-02-02)

ClinGen Genome Curation Page
Haploinsufficency

Dosage sensitivity unlikely (Last evaluated 2021-02-02)

ClinGen Genome Curation PagePubMed

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of kallikrein-related peptidase 12 (KLK12) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC42603, DKFZp686H1078

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables peptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables serine-type endopeptidase activity NAS
Non-traceable Author Statement
more info
PubMed 
enables serine-type peptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in extracellular space NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in secretory granule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
kallikrein-12
Names
kallikrein-like protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001370125.1NP_001357054.1  kallikrein-12 isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AC011473
    Related
    ENSP00000508282.1, ENST00000684732.1
    Conserved Domains (1) summary
    cd00190
    Location:22244
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  2. NM_001370126.1NP_001357055.1  kallikrein-12 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC011473
    Conserved Domains (1) summary
    cl27237
    Location:37126
    Trypsin
  3. NM_001370127.1NP_001357056.1  kallikrein-12 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC011473
    Conserved Domains (1) summary
    smart00020
    Location:37131
    Tryp_SPc; Trypsin-like serine protease
  4. NM_001370128.1NP_001357057.1  kallikrein-12 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC011473
    Conserved Domains (1) summary
    smart00020
    Location:37131
    Tryp_SPc; Trypsin-like serine protease
  5. NM_019598.3NP_062544.1  kallikrein-12 isoform 1 precursor

    See identical proteins and their annotated locations for NP_062544.1

    Status: REVIEWED

    Source sequence(s)
    AC011473
    Consensus CDS
    CCDS12820.1
    UniProtKB/Swiss-Prot
    Q9UKR0
    Related
    ENSP00000250351.4, ENST00000250351.4
    Conserved Domains (2) summary
    smart00020
    Location:21236
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:22236
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  6. NM_145894.2NP_665901.1  kallikrein-12 isoform 2 precursor

    See identical proteins and their annotated locations for NP_665901.1

    Status: REVIEWED

    Source sequence(s)
    AC011473
    Consensus CDS
    CCDS12821.1
    UniProtKB/Swiss-Prot
    Q9UKR0
    UniProtKB/TrEMBL
    A0A024R4M4
    Related
    ENSP00000324181.4, ENST00000319590.8
    Conserved Domains (1) summary
    cd00190
    Location:22244
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  7. NM_145895.2NP_665902.2  kallikrein-12 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC011473
    Consensus CDS
    CCDS54298.1
    Conserved Domains (1) summary
    smart00020
    Location:37131
    Tryp_SPc; Trypsin-like serine protease

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    51028954..51035648 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005258951.3XP_005259008.1  kallikrein-12 isoform X2

    See identical proteins and their annotated locations for XP_005259008.1

    UniProtKB/Swiss-Prot
    Q9UKR0
    Related
    ENSP00000434036.1, ENST00000529888.5
    Conserved Domains (1) summary
    cl21584
    Location:2263
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
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