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CG11155 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43822, updated on 6-Jul-2026
Official Symbol
CG11155provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0039927
Locus tag
Dmel_CG11155
See related
AllianceGenome:FB:FBgn0039927
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CT30863; DmelCG11155; Dmel\CG11155
Summary
Predicted to enable kainate selective glutamate receptor activity. Involved in glutamatergic synaptic transmission and positive regulation of synaptic plasticity. Is active in postsynaptic membrane. Is expressed in adult head and transmedullary neuron Tm5c. Human ortholog(s) of this gene implicated in Huntington's disease; autosomal recessive intellectual developmental disorder 6; and childhood absence epilepsy. Orthologous to several human genes including GRIK1 (glutamate ionotropic receptor kainate type subunit 1); GRIK2 (glutamate ionotropic receptor kainate type subunit 2); and GRIK3 (glutamate ionotropic receptor kainate type subunit 3). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See CG11155 in Genome Data Viewer
Location:
102F8-102F8; 4-0 cM
Exon count:
15
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 4 NC_004353.4 (1126602..1137919)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 4 NC_004353.3 (1147228..1158545)

Chromosome 4 - NC_004353.4Genomic Context describing neighboring genes Neighboring gene shaven Neighboring gene Calsyntenin Neighboring gene ADP ribosylation factor 4 Neighboring gene uncharacterized protein Neighboring gene Kinesin family member 3C Neighboring gene pleiohomeotic

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Population genomic inferences from sparse high-throughput sequencing of two populations of Drosophila melanogaster. Sackton TB, et al. Genome Biol Evol, 2009 Nov 18. PMID 20333214, Free PMC Article
  2. scRNA-seq data from the larval Drosophila ventral cord provides a resource for studying motor systems function and development. Nguyen TH, et al. Dev Cell, 2024 May 6. PMID 38569548, Free PMC Article
  3. An essential Drosophila glutamate receptor subunit that functions in both central neuropil and neuromuscular junction. Featherstone DE, et al. J Neurosci, 2005 Mar 23. PMID 15788777, Free PMC Article
  4. Novel Functional Properties of Drosophila CNS Glutamate Receptors. Li Y, et al. Neuron, 2016 Dec 7. PMID 27889096, Free PMC Article
  5. A hard-wired glutamatergic circuit pools and relays UV signals to mediate spectral preference in Drosophila. Karuppudurai T, et al. Neuron, 2014 Feb 5. PMID 24507194, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

Homology

mobile_element

  • Loc: 1127678-1128075 mobile_element_type = transposon:INE-1{}3938
  • Loc: 1130643-1130856 mobile_element_type = transposon:INE-1{}3940
  • Loc: 1136023-1136077 mobile_element_type = transposon:INE-1{}3945

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables kainate selective glutamate receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ligand-gated monoatomic ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ligand-gated monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ionotropic glutamate receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of synaptic activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in sensory perception IEA
Inferred from Electronic Annotation
more info
  
involved_in synaptic transmission, glutamatergic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynaptic membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in presynaptic membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
uncharacterized protein
Names
CG11155-PA
CG11155-PB
CG11155-PD

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004353.4 Reference assembly

    Range
    1126602..1137919
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_166825.3 → NP_726649.3  uncharacterized protein Dmel_CG11155, isoform D

    See identical proteins and their annotated locations for NP_726649.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    B5X0I7, Q5U168, Q8IM94, Q9V4A0
    Conserved Domains (4) summary
    cd06382
    Location:44 → 410
    PBP1_iGluR_Kainate; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the kainate receptors
    cd13714
    Location:424 → 793
    PBP2_iGluR_Kainate; Kainate receptor of the type 2 periplasmic-binding fold superfamily
    pfam00060
    Location:555 → 829
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:61 → 393
    ANF_receptor; Receptor family ligand binding region

  2. NM_143684.3 → NP_651941.2  uncharacterized protein Dmel_CG11155, isoform A

    See identical proteins and their annotated locations for NP_651941.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    B5X0I7, Q5U168, Q8IM94, Q9V4A0
    Conserved Domains (4) summary
    cd06382
    Location:44 → 410
    PBP1_iGluR_Kainate; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the kainate receptors
    cd13714
    Location:424 → 793
    PBP2_iGluR_Kainate; Kainate receptor of the type 2 periplasmic-binding fold superfamily
    pfam00060
    Location:555 → 829
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:61 → 393
    ANF_receptor; Receptor family ligand binding region

  3. NM_166824.3 → NP_726648.2  uncharacterized protein Dmel_CG11155, isoform B

    See identical proteins and their annotated locations for NP_726648.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IM95
    Conserved Domains (3) summary
    cd06382
    Location:44 → 410
    PBP1_iGluR_Kainate; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the kainate receptors
    pfam01094
    Location:61 → 393
    ANF_receptor; Receptor family ligand binding region
    cl21456
    Location:424 → 855
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5U168 Q5U168
Q8IM95 Q8IM95
Q8MSY7 Q8MSY7
Q9V4A0 Q9V4A0

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