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zfh2 Zn finger homeodomain 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43795, updated on 6-Jul-2026
Official Symbol
zfh2provided by FlyBase
Official Full Name
Zn finger homeodomain 2provided by FlyBase
Primary source
FLYBASE:FBgn0004607
Locus tag
Dmel_CG1449
See related
AllianceGenome:FB:FBgn0004607
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1449; Dmel\CG1449; zfh-2; Zfh-2; ZFH-2; Zfh2; ZFH2
Summary
Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in imaginal disc-derived wing morphogenesis and nervous system development. Located in nucleus. Is expressed in several structures, including anlage in statu nascendi; imaginal disc; larval neurons; longitudinal glial cell; and somatic precursor cell. Human ortholog(s) of this gene implicated in several diseases, including Marsili syndrome; familial atrial fibrillation; hepatocellular carcinoma; lung non-small cell carcinoma (multiple); and spinocerebellar ataxia type 4. Orthologous to several human genes including ZFHX3 (zinc finger homeobox 3) and ZFHX4 (zinc finger homeobox 4). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
all
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See zfh2 in Genome Data Viewer
Location:
102C3-102C4; 4-0 cM
Exon count:
15
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 4 NC_004353.4 (501810..540874)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 4 NC_004353.3 (522436..561500)

Chromosome 4 - NC_004353.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45126 Neighboring gene TBP-associated factor 3 Neighboring gene uncharacterized protein Neighboring gene asator Neighboring gene Thymine DNA glycosylase Neighboring gene long non-coding RNA:CR43958 Neighboring gene Purine-rich binding protein-alpha

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. A new visible light DNA fluorochrome for confocal microscopy. Lundell MJ, et al. Biotechniques, 1994 Mar. PMID 8185917
  2. A new family of homeobox genes encoding multiple homeodomain and zinc finger motifs. Hashimoto T, et al. Mech Dev, 1992 Nov. PMID 1362648
  3. Programmed cell senescence is required for sensory organ development in Drosophila. Zang Y, et al. iScience, 2025 Mar 21. PMID 40124515, Free PMC Article
  4. ZFH-2 is required for Drosophila ovarian follicle development and is expressed at the band/interband boundaries of polytene chromosomes. Guntur AR, et al. Dev Biol, 2023 Dec. PMID 37666353
  5. The Drosophila zfh-1 and zfh-2 genes encode novel proteins containing both zinc-finger and homeodomain motifs. Fortini ME, et al. Mech Dev, 1991 Jun. PMID 1680376

See all (160) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZFH-2 is required for Drosophila ovarian follicle development and is expressed at the band/interband boundaries of polytene chromosomes.
    Title: ZFH-2 is required for Drosophila ovarian follicle development and is expressed at the band/interband boundaries of polytene chromosomes.
  2. Zfh-2 facilitates Notch-induced apoptosis in the CNS and appendages of Drosophila melanogaster.
    Title: Zfh-2 facilitates Notch-induced apoptosis in the CNS and appendages of Drosophila melanogaster.
  3. Study identifies the cascade of cellular changes and regulatory steps that control differentiation in the adult fly midgut and identifies zfh2 as a major player in these processes.
    Title: zfh2 controls progenitor cell activation and differentiation in the adult Drosophila intestinal absorptive lineage.
  4. these results identify Zfh2 as the first in vivo mediator of hypercapnic immune suppression.
    Title: Identification of Drosophila Zfh2 as a Mediator of Hypercapnic Immune Regulation by a Genome-Wide RNA Interference Screen.
  5. results demonstrate the key role of zfh-2 in the control of cell death and Notch signaling during leg development
    Title: The zinc finger homeodomain-2 gene of Drosophila controls Notch targets and regulates apoptosis in the tarsal segments.
  6. Zfh2 plays an important role controlling the expression of several wing genes and in the specification of cellular properties that define the differences in cell proliferation between proximal and distal domains of the wing disc.
    Title: Multiple roles of the gene zinc finger homeodomain-2 in the development of the Drosophila wing.
  7. In discs lacking zfh2 the limits of the expression domains of the genes tsh, nub, rn, dve and nab coincide, and expression of wg in the wing hinge, is lost.
    Title: The Drosophila gene zfh2 is required to establish proximal-distal domains in the wing disc.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

mobile_element

  • Loc: 511460-511517 mobile_element_type = transposon:1360{}6091
  • Loc: 511697-511750 mobile_element_type = transposon:INE-1{}5956
  • Loc: 511816-511931 mobile_element_type = transposon:INE-1{}5957
  • Loc: 514139-514480 mobile_element_type = transposon:INE-1{}5959
  • Loc: 518675-518810 mobile_element_type = transposon:INE-1{}5962
  • Loc: 518831-518878 mobile_element_type = transposon:INE-1{}5383
  • Loc: 520400-520647 mobile_element_type = transposon:INE-1{}5384
  • Loc: 527166-527206 mobile_element_type = transposon:1360{}6092

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding TAS
Traceable Author Statement
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in imaginal disc-derived wing morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nervous system development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in wing disc development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
Zn finger homeodomain 2
Names
CG1449-PA
CG1449-PB
CG1449-PC
zfh2-PA
zfh2-PB
zfh2-PC
zinc finger homeodomain 2
zinc finger homeodomain-2
zn finger homeodomain 2

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004353.4 Reference assembly

    Range
    501810..540874
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001258496.3 → NP_001245425.1  Zn finger homeodomain 2, isoform B

    See identical proteins and their annotated locations for NP_001245425.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H9XVP0
    Conserved Domains (4) summary
    smart00389
    Location:1795 → 1851
    HOX; Homeodomain
    sd00017
    Location:561 → 581
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:1515 → 1542
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00046
    Location:2762 → 2814
    Homeobox; Homeobox domain

  2. NM_079884.5 → NP_524623.2  Zn finger homeodomain 2, isoform A

    See identical proteins and their annotated locations for NP_524623.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P28167, Q95SN9, Q9V4D7
    Related
    FBpp0088139
    Conserved Domains (4) summary
    smart00389
    Location:1797 → 1853
    HOX; Homeodomain
    sd00017
    Location:561 → 581
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:1515 → 1542
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00046
    Location:2764 → 2816
    Homeobox; Homeobox domain

  3. NM_001272130.1 → NP_001259059.1  Zn finger homeodomain 2, isoform C

    See identical proteins and their annotated locations for NP_001259059.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    L0MLK7
    Conserved Domains (4) summary
    smart00389
    Location:1797 → 1853
    HOX; Homeodomain
    sd00017
    Location:561 → 581
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:1515 → 1542
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00046
    Location:2158 → 2210
    Homeobox; Homeobox domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
H9XVP0 H9XVP0
L0MLK7 L0MLK7
P28167.2 P28167

Gene LinkOut

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