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Asator asator [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43794, updated on 6-Jul-2026
Official Symbol
Asatorprovided by FlyBase
Official Full Name
asatorprovided by FlyBase
Primary source
FLYBASE:FBgn0039908
Locus tag
Dmel_CG11533
See related
AllianceGenome:FB:FBgn0039908
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11533; CK I; CKI-like; Dmel\CG11533
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in signal transduction. Located in cytoplasm and spindle. Is expressed in adult head. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 11. Orthologous to human TTBK1 (tau tubulin kinase 1) and TTBK2 (tau tubulin kinase 2). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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Try the new Transcripts and proteins table
See Asator in Genome Data Viewer
Location:
102C1-102C1; 4-0 cM
Exon count:
17
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 4 NC_004353.4 (469409..488994, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 4 NC_004353.3 (490035..509620, complement)

Chromosome 4 - NC_004353.4Genomic Context describing neighboring genes Neighboring gene Calcium/calmodulin-dependent protein kinase I Neighboring gene antisense RNA:CR45126 Neighboring gene TBP-associated factor 3 Neighboring gene uncharacterized protein Neighboring gene Zn finger homeodomain 2 Neighboring gene long non-coding RNA:CR43958 Neighboring gene Thymine DNA glycosylase

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Asator, a tau-tubulin kinase homolog in Drosophila localizes to the mitotic spindle. Qi H, et al. Dev Dyn, 2009 Dec. PMID 19890914
  2. Discovery of supernumerary B chromosomes in Drosophila melanogaster. Bauerly E, et al. Genetics, 2014 Apr. PMID 24478336, Free PMC Article
  3. Anterior repression of a Drosophila stripe enhancer requires three position-specific mechanisms. Andrioli LP, et al. Development, 2002 Nov. PMID 12397102
  4. Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex. Kramps T, et al. Cell, 2002 Apr 5. PMID 11955446
  5. Integrated omics in Drosophila uncover a circadian kinome. Wang C, et al. Nat Commun, 2020 Jun 1. PMID 32483184, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

mobile_element

  • Loc: c476399-476344 mobile_element_type = transposon:INE-1{}5932
  • Loc: c476483-476402 mobile_element_type = transposon:INE-1{}5934

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spindle IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
asator
Names
Asator-PD
Asator-PE
Asator-PF
Asator-PG
Asator-PH
Asator-PI
Asator-PJ
Asator-PK
Asator-PL
CG11533-PD
CG11533-PE
CG11533-PF
CG11533-PG
CG11533-PH
CG11533-PI
CG11533-PJ
CG11533-PK
CG11533-PL
NP_001259054.1
NP_001259055.1
NP_001259056.1
NP_001259057.1
NP_001259058.1
NP_001284714.1
NP_651924.2
NP_726576.2
NP_726577.2

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004353.4 Reference assembly

    Range
    469409..488994 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001272127.1 → NP_001259056.1  asator, isoform I

    See identical proteins and their annotated locations for NP_001259056.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8E766, L0MPX5
    Conserved Domains (2) summary
    smart00220
    Location:172 → 413
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14017
    Location:171 → 432
    STKc_TTBK; Catalytic domain of the Serine/Threonine protein kinase, Tau-Tubulin Kinase

  2. NM_166766.3 → NP_726577.2  asator, isoform F

    See identical proteins and their annotated locations for NP_726577.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8IMC6
    Conserved Domains (2) summary
    smart00220
    Location:17 → 258
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14017
    Location:16 → 277
    STKc_TTBK; Catalytic domain of the Serine/Threonine protein kinase, Tau-Tubulin Kinase

  3. NM_001272126.2 → NP_001259055.1  asator, isoform H

    See identical proteins and their annotated locations for NP_001259055.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8E766, L0MPN7
    Conserved Domains (2) summary
    smart00220
    Location:17 → 258
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14017
    Location:16 → 277
    STKc_TTBK; Catalytic domain of the Serine/Threonine protein kinase, Tau-Tubulin Kinase

  4. NM_143667.3 → NP_651924.2  asator, isoform D

    See identical proteins and their annotated locations for NP_651924.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8E766, Q9V4D6
    Conserved Domains (2) summary
    smart00220
    Location:173 → 414
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14017
    Location:172 → 433
    STKc_TTBK; Catalytic domain of the Serine/Threonine protein kinase, Tau-Tubulin Kinase

  5. NM_001297785.1 → NP_001284714.1  asator, isoform L

    See identical proteins and their annotated locations for NP_001284714.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8E766, L0MLN1
    Conserved Domains (2) summary
    smart00220
    Location:17 → 258
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14017
    Location:16 → 277
    STKc_TTBK; Catalytic domain of the Serine/Threonine protein kinase, Tau-Tubulin Kinase

  6. NM_001272128.1 → NP_001259057.1  asator, isoform J

    See identical proteins and their annotated locations for NP_001259057.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8E766, L0MN72
    Conserved Domains (2) summary
    smart00220
    Location:172 → 413
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14017
    Location:171 → 432
    STKc_TTBK; Catalytic domain of the Serine/Threonine protein kinase, Tau-Tubulin Kinase

  7. NM_001272129.1 → NP_001259058.1  asator, isoform K

    See identical proteins and their annotated locations for NP_001259058.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8E766, L0MLN1
    Conserved Domains (2) summary
    smart00220
    Location:17 → 258
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14017
    Location:16 → 277
    STKc_TTBK; Catalytic domain of the Serine/Threonine protein kinase, Tau-Tubulin Kinase

  8. NM_001272125.1 → NP_001259054.1  asator, isoform G

    See identical proteins and their annotated locations for NP_001259054.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8E766, L0MLK2
    Conserved Domains (2) summary
    smart00220
    Location:173 → 414
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14017
    Location:172 → 433
    STKc_TTBK; Catalytic domain of the Serine/Threonine protein kinase, Tau-Tubulin Kinase

  9. NM_166765.3 → NP_726576.2  asator, isoform E

    See identical proteins and their annotated locations for NP_726576.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8IMC5, Q8IMC6
    UniProtKB/TrEMBL
    A8E766
    Conserved Domains (1) summary
    cd14017
    Location:172 → 433
    STKc_TTBK; Catalytic domain of the Serine/Threonine protein kinase, Tau-Tubulin Kinase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
L0MLK2 L0MLK2
L0MLN1 L0MLN1
L0MN72 L0MN72
L0MPN7 L0MPN7
L0MPX5 L0MPX5
Q8IMC6.2 Q8IMC6
Q9V4D6 Q9V4D6

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