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ORF8 ORF8 protein [ Severe acute respiratory syndrome coronavirus 2 ]

Gene ID: 43740577, updated on 16-Jun-2026
Gene symbol
ORF8
Gene description
ORF8 protein
Locus tag
GU280_gp09
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Severe acute respiratory syndrome coronavirus 2 (isolate: Wuhan-Hu-1, nat-host: Homo sapiens)
Lineage
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes; Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae; Betacoronavirus; Sarbecovirus
Summary
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped, positive-sense, single-stranded RNA virus that causes coronavirus disease 2019 (COVID-19). Virus particles include the RNA genetic material and structural proteins needed for invasion of host cells. Once inside the cell the infecting RNA is used to encode structural proteins that make up virus particles, nonstructural proteins that direct virus assembly, transcription, replication and host control and accessory proteins whose function has not been determined.~ ORF8 encodes a viral accessory protein.
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Sequence:
NC_045512.2 (27894..28259)

NC_045512.2Genomic Context describing neighboring genes Neighboring gene ORF6 protein Neighboring gene ORF7a protein Neighboring gene ORF7b Neighboring gene nucleocapsid phosphoprotein Neighboring gene ORF10 protein

Genomic Sequence:
NC_045512.2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Crystallographic molecular replacement using an in silico-generated search model of SARS-CoV-2 ORF8. Flower TG, et al. Protein Sci, 2021 Apr. PMID 33625752, Free PMC Article
  2. Identification of a novel SARS-CoV-2 variant with a truncated protein in ORF8 gene by next generation sequencing. DeRonde S, et al. Sci Rep, 2022 Mar 17. PMID 35301412, Free PMC Article
  3. An issue of concern: unique truncated ORF8 protein variants of SARS-CoV-2. Hassan SS, et al. PeerJ, 2022. PMID 35341060, Free PMC Article
  4. ORF8 protein of SARS-CoV-2 reduces male fertility in mice. Yu T, et al. J Med Virol, 2022 Sep. PMID 35570330, Free PMC Article
  5. SARS-CoV-2 ORF8 reshapes the ER through forming mixed disulfides with ER oxidoreductases. Liu P, et al. Redox Biol, 2022 Aug. PMID 35792438, Free PMC Article

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SARS-CoV-2 Accessory Protein ORF8 Targets the Dimeric IgA Receptor pIgR.
    Title: SARS-CoV-2 Accessory Protein ORF8 Targets the Dimeric IgA Receptor pIgR.
  2. Positive selection underlies repeated knockout of ORF8 in SARS-CoV-2 evolution.
    Title: Positive selection underlies repeated knockout of ORF8 in SARS-CoV-2 evolution.
  3. A survey of ORF8 sequence and immunoinformatics features during alpha, delta, and wild type peaks of the SARS-CoV-2 pandemic in Iran.
    Title: A survey of ORF8 sequence and immunoinformatics features during alpha, delta, and wild type peaks of the SARS-CoV-2 pandemic in Iran.
  4. SARS-CoV-2 ORF8 does not function in the nucleus as a histone mimic.
    Title: SARS-CoV-2 ORF8 does not function in the nucleus as a histone mimic.
  5. SARS-CoV-2 ORF8 accessory protein is a virulence factor.
    Title: SARS-CoV-2 ORF8 accessory protein is a virulence factor.
  6. SARS-CoV-2 protein ORF8 limits expression levels of Spike antigen and facilitates immune evasion of infected host cells.
    Title: SARS-CoV-2 protein ORF8 limits expression levels of Spike antigen and facilitates immune evasion of infected host cells.
  7. SARS-CoV-2 ORF8 Mediates Signals in Macrophages and Monocytes through MyD88 Independently of the IL-17 Receptor.
    Title: SARS-CoV-2 ORF8 Mediates Signals in Macrophages and Monocytes through MyD88 Independently of the IL-17 Receptor.
  8. SARS-CoV-2 ORF8 dimerization and binding mode analysis with class I MHC: computational approaches to identify COVID-19 inhibitors.
    Title: SARS-CoV-2 ORF8 dimerization and binding mode analysis with class I MHC: computational approaches to identify COVID-19 inhibitors.
  9. SARS-CoV-2-encoded ORF8 protein possesses complement inhibitory properties.
    Title: SARS-CoV-2-encoded ORF8 protein possesses complement inhibitory properties.
  10. Defective ORF8 dimerization in SARS-CoV-2 delta variant leads to a better adaptive immune response due to abrogation of ORF8-MHC1 interaction.
    Title: Defective ORF8 dimerization in SARS-CoV-2 delta variant leads to a better adaptive immune response due to abrogation of ORF8-MHC1 interaction.
Submit: New GeneRIF Correction See all GeneRIFs (31)
Products Interactant Other Gene Complex Source Pubs Description
Preferred Names
ORF8 protein

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_045512.2 Reference assembly

    Range
    27894..28259
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_009724396.1 ORF8 protein [Severe acute respiratory syndrome coronavirus 2]

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P0DTC8
    UniProtKB/TrEMBL
    A0A6B9VKN0, A0A6B9VTP3, A0A6C1B858, A0A886N1N4, A0A8B1JH95
    Conserved Domains (1) summary
    cd21641
    Location:1 → 121
    ORF8-Ig_SARS-CoV-2-like; SARS-CoV-2 ORF8 immunoglobulin (Ig) domain protein and related proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0DTC8.1 P0DTC8

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