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E envelope protein [ Severe acute respiratory syndrome coronavirus 2 ]

Gene ID: 43740570, updated on 11-May-2025
Gene symbol
E
Gene description
envelope protein
Locus tag
GU280_gp04
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Severe acute respiratory syndrome coronavirus 2 (isolate: Wuhan-Hu-1, nat-host: Homo sapiens)
Lineage
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes; Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae; Betacoronavirus; Sarbecovirus
Summary
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped, positive-sense, single-stranded RNA virus that causes coronavirus disease 2019 (COVID-19). Virus particles include the RNA genetic material and structural proteins needed for invasion of host cells. Once inside the cell the infecting RNA is used to encode structural proteins that make up virus particles, nonstructural proteins that direct virus assembly, transcription, replication and host control and accessory proteins whose function has not been determined.~ The structural proteins of SARS-CoV-2 include the envelope protein (E), spike or surface glycoprotein (S), membrane protein (M) and the nucleocapsid protein (N). The envelope protein is found in virus particles. This protein facilitates assembly and release of the virus and has ion channel activity required for pathogenesis.
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Sequence:
NC_045512.2 (26245..26472)

NC_045512.2Genomic Context describing neighboring genes Neighboring gene surface glycoprotein Neighboring gene ORF3a protein Neighboring gene membrane glycoprotein Neighboring gene ORF6 protein

Genomic Sequence:
NC_045512.2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Structure and dynamics of the SARS-CoV-2 envelope protein monomer. Kuzmin A, et al. Proteins, 2022 May. PMID 35119706
  2. Oligomerization-Dependent Beta-Structure Formation in SARS-CoV-2 Envelope Protein. Surya W, et al. Int J Mol Sci, 2022 Oct 31. PMID 36362071, Free PMC Article
  3. Characterization of the SARS-CoV-2 E Protein: Sequence, Structure, Viroporin, and Inhibitors. Cao Y, et al. Protein Sci, 2021 Jun. PMID 33813796, Free PMC Article
  4. The Cytoplasmic Domain of the SARS-CoV-2 Envelope Protein Assembles into a β-Sheet Bundle in Lipid Bilayers. Dregni AJ, et al. J Mol Biol, 2023 Mar 1. PMID 36682677, Free PMC Article
  5. SARS-CoV-2 Envelope Protein Forms Clustered Pentamers in Lipid Bilayers. Somberg NH, et al. Biochemistry, 2022 Nov 1. PMID 36219675, Free PMC Article

See all (62) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A short sequence in the tail of SARS-CoV-2 envelope protein controls accessibility of its PDZ-binding motif to the cytoplasm.
    Title: A short sequence in the tail of SARS-CoV-2 envelope protein controls accessibility of its PDZ-binding motif to the cytoplasm.
  2. Atomic structure of the open SARS-CoV-2 E viroporin.
    Title: Atomic structure of the open SARS-CoV-2 E viroporin.
  3. The Cytoplasmic Domain of the SARS-CoV-2 Envelope Protein Assembles into a beta-Sheet Bundle in Lipid Bilayers.
    Title: The Cytoplasmic Domain of the SARS-CoV-2 Envelope Protein Assembles into a β-Sheet Bundle in Lipid Bilayers.
  4. SARS-CoV-2 Harnesses Host Translational Shutoff and Autophagy To Optimize Virus Yields: the Role of the Envelope (E) Protein.
    Title: SARS-CoV-2 Harnesses Host Translational Shutoff and Autophagy To Optimize Virus Yields: the Role of the Envelope (E) Protein.
  5. Binding of the SARS-CoV-2 envelope E protein to human BRD4 is essential for infection.
    Title: Binding of the SARS-CoV-2 envelope E protein to human BRD4 is essential for infection.
  6. SARS-CoV-2 Envelope (E) Protein Binds and Activates TLR2 Pathway: A Novel Molecular Target for COVID-19 Interventions.
    Title: SARS-CoV-2 Envelope (E) Protein Binds and Activates TLR2 Pathway: A Novel Molecular Target for COVID-19 Interventions.
  7. Structure and dynamics of the SARS-CoV-2 envelope protein monomer.
    Title: Structure and dynamics of the SARS-CoV-2 envelope protein monomer.
  8. Surface Proteins of SARS-CoV-2 Drive Airway Epithelial Cells to Induce IFN-Dependent Inflammation.
    Title: Surface Proteins of SARS-CoV-2 Drive Airway Epithelial Cells to Induce IFN-Dependent Inflammation.
  9. Small Structural Proteins E and M Render the SARS-CoV-2 Pseudovirus More Infectious and Reveal the Phenotype of Natural Viral Variants.
    Title: Small Structural Proteins E and M Render the SARS-CoV-2 Pseudovirus More Infectious and Reveal the Phenotype of Natural Viral Variants.
  10. TLR2 senses the SARS-CoV-2 envelope protein to produce inflammatory cytokines.
    Title: TLR2 senses the SARS-CoV-2 envelope protein to produce inflammatory cytokines.
Submit: New GeneRIF Correction See all GeneRIFs (21)
Products Interactant Other Gene Complex Source Pubs Description
Preferred Names
envelope protein
YP_009724392.1
  • ORF4; structural protein; E protein

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_045512.2 Reference assembly

    Range
    26245..26472
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_009724392.1 envelope protein [Severe acute respiratory syndrome coronavirus 2]

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P0DTC4
    UniProtKB/TrEMBL
    A0A2R3SUY7, A0A6B9WFC7, A0A6C0QFP9, A0A6V7AL81, A0A6V7ALI4, A0A7D5I1K7
    Conserved Domains (1) summary
    cd21536
    Location:2 → 75
    SARS-CoV-2_E; Severe acute respiratory syndrome coronavirus 2 Envelope small membrane protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0DTC4.1 P0DTC4

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