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E envelope protein [ Severe acute respiratory syndrome coronavirus 2 ]

Gene ID: 43740570, updated on 8-Jan-2023

Summary

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Gene symbol
E
Gene description
envelope protein
Locus tag
GU280_gp04
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Severe acute respiratory syndrome coronavirus 2 (isolate: Wuhan-Hu-1, nat-host: Homo sapiens)
Lineage
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes; Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae; Betacoronavirus; Sarbecovirus
Summary
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped, positive-sense, single-stranded RNA virus that causes coronavirus disease 2019 (COVID-19). Virus particles include the RNA genetic material and structural proteins needed for invasion of host cells. Once inside the cell the infecting RNA is used to encode structural proteins that make up virus particles, nonstructural proteins that direct virus assembly, transcription, replication and host control and accessory proteins whose function has not been determined.~ The structural proteins of SARS-CoV-2 include the envelope protein (E), spike or surface glycoprotein (S), membrane protein (M) and the nucleocapsid protein (N). The envelope protein is found in virus particles. This protein facilitates assembly and release of the virus and has ion channel activity required for pathogenesis.
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Genomic context

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Sequence:
NC_045512.2 (26245..26472)

NC_045512.2Genomic Context describing neighboring genes Neighboring gene surface glycoprotein Neighboring gene ORF3a protein Neighboring gene membrane glycoprotein Neighboring gene ORF6 protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_045512.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. SARS-CoV-2 Envelope (E) Protein Binds and Activates TLR2 Pathway: A Novel Molecular Target for COVID-19 Interventions. Planès R, et al. Viruses, 2022 May 8. PMID 35632741, Free PMC Article
  2. Structure and dynamics of the SARS-CoV-2 envelope protein monomer. Kuzmin A, et al. Proteins, 2022 May. PMID 35119706
  3. Characterization of the SARS-CoV-2 E Protein: Sequence, Structure, Viroporin, and Inhibitors. Cao Y, et al. Protein Sci, 2021 Jun. PMID 33813796, Free PMC Article
  4. Structure and drug binding of the SARS-CoV-2 envelope protein transmembrane domain in lipid bilayers. Mandala VS, et al. Nat Struct Mol Biol, 2020 Dec. PMID 33177698, Free PMC Article
  5. A SARS-CoV-2 variant with the 12-bp deletion at E gene. Sun YS, et al. Emerg Microbes Infect, 2020 Dec. PMID 33118859, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Binding of the SARS-CoV-2 envelope E protein to human BRD4 is essential for infection.
    Title: Binding of the SARS-CoV-2 envelope E protein to human BRD4 is essential for infection.
  2. SARS-CoV-2 Envelope (E) Protein Binds and Activates TLR2 Pathway: A Novel Molecular Target for COVID-19 Interventions.
    Title: SARS-CoV-2 Envelope (E) Protein Binds and Activates TLR2 Pathway: A Novel Molecular Target for COVID-19 Interventions.
  3. Structure and dynamics of the SARS-CoV-2 envelope protein monomer.
    Title: Structure and dynamics of the SARS-CoV-2 envelope protein monomer.
  4. Surface Proteins of SARS-CoV-2 Drive Airway Epithelial Cells to Induce IFN-Dependent Inflammation.
    Title: Surface Proteins of SARS-CoV-2 Drive Airway Epithelial Cells to Induce IFN-Dependent Inflammation.
  5. Small Structural Proteins E and M Render the SARS-CoV-2 Pseudovirus More Infectious and Reveal the Phenotype of Natural Viral Variants.
    Title: Small Structural Proteins E and M Render the SARS-CoV-2 Pseudovirus More Infectious and Reveal the Phenotype of Natural Viral Variants.
  6. TLR2 senses the SARS-CoV-2 envelope protein to produce inflammatory cytokines.
    Title: TLR2 senses the SARS-CoV-2 envelope protein to produce inflammatory cytokines.
  7. Structural basis of coronavirus E protein interactions with human PALS1 PDZ domain.
    Title: Structural basis of coronavirus E protein interactions with human PALS1 PDZ domain.
  8. Structural basis for SARS-CoV-2 envelope protein recognition of human cell junction protein PALS1.
    Title: Structural basis for SARS-CoV-2 envelope protein recognition of human cell junction protein PALS1.
  9. Characterization of the SARS-CoV-2 E Protein: Sequence, Structure, Viroporin, and Inhibitors.
    Title: Characterization of the SARS-CoV-2 E Protein: Sequence, Structure, Viroporin, and Inhibitors.
  10. Evolution of SARS-CoV-2 Envelope, Membrane, Nucleocapsid, and Spike Structural Proteins from the Beginning of the Pandemic to September 2020: A Global and Regional Approach by Epidemiological Week.
    Title: Evolution of SARS-CoV-2 Envelope, Membrane, Nucleocapsid, and Spike Structural Proteins from the Beginning of the Pandemic to September 2020: A Global and Regional Approach by Epidemiological Week.
Submit: New GeneRIF Correction See all GeneRIFs (17)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General protein information

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Preferred Names
envelope protein
YP_009724392.1
  • ORF4; structural protein; E protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_045512.2 Reference assembly

    Range
    26245..26472
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_009724392.1 envelope protein [Severe acute respiratory syndrome coronavirus 2]

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P0DTC4
    UniProtKB/TrEMBL
    A0A2R3SUY7, A0A6B9WFC7, A0A6B9WFI6, A0A6G6A2K2, A0A6V7AL81, A0A6V7ALI4, A0A7D5I1K7, A0A7U3VGW5, A0A7U3VH07, A0A7U3VI45, A0A7U3VI51, A0A7U3VIB4, A0A8F0ZV93
    Conserved Domains (1) summary
    cd21536
    Location:2 → 75
    SARS-CoV-2_E; Severe acute respiratory syndrome coronavirus 2 Envelope small membrane protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0DTC4.1 P0DTC4
QLH64781.1
QLH64793.1
QLH64805.1
QLH64817.1
QLH64829.1
QLH64841.1
QLH64853.1
QLH64865.1
QLH64879.1
QLH64891.1
QLH64903.1
QLH64919.1
QLH64931.1
QLH64943.1
QLH90044.1
QLH90080.1
QLH90092.1
QLH90105.1
QLH93121.1
QLH93133.1
QLH93189.1
QLH93203.1
QLH93216.1
QLH93287.1
QLH93430.1
QLH93442.1
QLH93454.1
QLH93632.1
QLH93644.1
QLH93656.1
QLI33446.1
QLI33458.1
QLI33470.1
QLI33482.1
QLI33494.1
QLI33506.1
QLI33518.1
QLI33530.1
QLI33542.1
QLI33554.1
QLI33566.1
QLI33578.1
QLI33590.1
QLI33602.1
QLI33614.1
QLI33626.1
QLI33638.1
QLI33650.1
QLI33662.1
QLI33674.1
QLI46291.1
QLI46303.1
QLI49591.1
QLI49603.1
QLI49615.1
QLI49627.1
QLI49639.1
QLI49651.1
QLI49663.1
QLI49699.1
QLI49711.1
QLI49723.1
QLI49735.1
QLI49747.1
QLI49759.1
QLI49771.1
QLI49783.1
QLI49795.1
QLI49807.1
QLI49819.1
QLI49923.1
QLI49935.1
QLI49947.1
QLI49959.1
QLI49971.1
QLI49983.1
QLI49995.1
QLI50007.1
QLI50019.1
QLI50031.1
QLI50043.1
QLI50055.1
QLI50067.1
QLI50079.1
QLI50091.1
QLI50103.1
QLI50115.1
QLI50127.1
QLI50139.1
QLI50151.1
QLI50163.1
QLI50175.1
QLI50187.1
QLI50199.1
QLI50211.1
QLI50223.1
QLI50235.1
QLI50247.1
QLI50259.1
QLI50271.1
QLI50283.1
QLI50295.1
QLI50307.1
QLI50319.1
QLI50331.1
QLI50343.1
QLI50355.1
QLI50367.1
QLI50379.1
QLI50391.1
QLI50403.1
QLI50415.1
QLI50427.1
QLI50439.1
QLI50451.1
QLI50463.1
QLI50475.1
QLI50487.1
QLI50499.1
QLI50511.1
QLI50523.1
QLI50535.1
QLI50547.1
QLI50559.1
QLI50571.1
QLI50583.1
QLI50595.1
QLI50607.1
QLI50619.1
QLI50643.1
QLI50655.1
QLI50667.1
QLI50679.1
QLI50691.1
QLI50703.1
QLI50715.1
QLI50727.1
QLI50739.1
QLI50751.1
QLI50763.1
QLI50775.1
QLI50787.1
QLI50799.1
QLI50811.1
QLI50823.1
QLI50835.1
QLI50847.1
QLI50859.1
QLI50871.1
QLI50883.1
QLI50895.1
QLI50907.1
QLI50919.1
QLI50931.1
QLI50943.1
QLI50955.1
QLI50967.1
QLI50979.1
QLI50991.1
QLI51003.1
QLI51015.1
QLI51027.1
QLI51039.1
QLI51051.1
QLI51063.1
QLI51075.1
QLI51087.1
QLI51099.1
QLI51111.1
QLI51123.1
QLI51135.1
QLI51147.1
QLI51159.1
QLI51171.1
QLI51183.1
QLI51195.1
QLI51207.1
QLI51219.1
QLI51231.1
QLI51243.1
QLI51255.1
QLI51267.1
QLI51279.1
QLI51291.1
QLI51303.1
QLI51315.1
QLI51327.1
QLI51339.1
QLI51351.1
QLI51363.1
QLI51375.1
QLI51387.1
QLI51399.1
QLI51411.1
QLI51423.1
QLI51435.1
QLI51447.1
QLI51459.1
QLI51471.1
QLI51483.1
QLI51495.1
QLI51507.1
QLI51519.1
QLI51531.1
QLI51543.1
QLI51555.1
QLI51567.1
QLI51579.1
QLI51591.1
QLI51603.1
QLI51615.1
QLI51627.1
QLI51639.1
QLI51651.1
QLI51663.1
QLI51675.1
QLI51687.1
QLI51699.1
QLI51711.1
QLI51723.1
QLI51735.1
QLI51747.1
QLI51759.1
QLI51771.1
QLI51783.1
QLI51795.1
QLI51807.1
QLI51819.1
QLI51831.1
QLI51843.1
QLI51855.1
QLI51867.1
QLI51879.1
QLI51891.1
QLI51903.1
QLI51915.1
QLI51927.1
QLI51939.1
QLI51951.1
QLI51963.1
QLI51975.1
QLI51987.1
QLI51999.1
QLI52011.1
QLI52023.1
QLI52035.1
QLI52047.1
QLI52059.1
QLI52071.1

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