tyrp1b tyrosinase-related protein 1b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tyrp1bprovided by ZNC
Official Full Name: tyrosinase-related protein 1bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040718-249
See related: Ensembl:ENSDARG00000056151 AllianceGenome:ZFIN:ZDB-GENE-040718-249
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: tyrp1; hm:zeh0659; zgc:100893
Summary: Predicted to enable oxidoreductase activity. Acts upstream of or within several processes, including melanosome organization; response to thyroid hormone; and retinal pigment epithelium development. Predicted to be located in melanosome membrane. Predicted to be integral component of membrane. Predicted to be active in melanosome. Is expressed in several structures, including eye; hatching gland; immature eye; melanoblast; and pigment cell. Human ortholog(s) of this gene implicated in oculocutaneous albinism; oculocutaneous albinism type III; and pigmentation disease. Orthologous to human TYRP1 (tyrosinase related protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 1

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (19332803..19346050)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (18639866..18653113)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Fugu tyrp1 promoter can direct transgene expression in a cell-type-specific manner in zebrafish. Our findings provide evidence supporting differential regulations of melanin-synthesizing genes in RPE cells and the NCDM in zebrafish.
Title: The Fugu tyrp1 promoter directs specific GFP expression in zebrafish: tools to study the RPE and the neural crest-derived melanophores.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within developmental pigmentation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within melanin biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in melanocyte differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within melanocyte differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in melanosome organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within melanosome organization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within pigmentation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to thyroid hormone	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within retinal pigment epithelium development	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in melanosome	IBA Inferred from Biological aspect of Ancestor more info
located_in melanosome membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tyrosinase-related protein 1b

Names: oca3; tyrosinase-related protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.