U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

gata2b GATA binding protein 2b [ Danio rerio (zebrafish) ]

Gene ID: 436962, updated on 2-Nov-2024

Summary

Official Symbol
gata2bprovided by ZNC
Official Full Name
GATA binding protein 2bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040718-440
See related
Ensembl:ENSDARG00000009094 AllianceGenome:ZFIN:ZDB-GENE-040718-440
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:91840
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within definitive hemopoiesis and hematopoietic stem cell differentiation. Predicted to be active in nucleus. Is expressed in several structures, including cardiovascular system; caudal fin; endothelial cell; hematopoietic system; and neurons. Human ortholog(s) of this gene implicated in acute myeloid leukemia; depressive disorder; immunodeficiency 21; myelodysplastic syndrome; and myeloid leukemia. Orthologous to human GATA2 (GATA binding protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See gata2b in Genome Data Viewer
Location:
chromosome: 6
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (40794017..40803800)
105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (40796472..40806373)

Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene si:ch211-157b11.8 Neighboring gene H1.10 linker histone Neighboring gene eukaryotic elongation factor, selenocysteine-tRNA-specific Neighboring gene RuvB-like AAA ATPase 1

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General gene information

Markers

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
endothelial transcription factor GATA-2b

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002689.2NP_001002689.2  endothelial transcription factor GATA-2b

    Status: VALIDATED

    Source sequence(s)
    CR450814
    UniProtKB/TrEMBL
    A0A8M3ATI9, F1QD30
    Related
    ENSDARP00000120165.1, ENSDART00000144479.2

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007117.7 Reference GRCz11 Primary Assembly

    Range
    40794017..40803800
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)