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egr3 early growth response 3 [ Danio rerio (zebrafish) ]

Gene ID: 436920, updated on 27-Mar-2024

Summary

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Official Symbol
egr3provided by ZNC
Official Full Name
early growth response 3provided by ZNC
Primary source
ZFIN:ZDB-GENE-040718-394
See related
Ensembl:ENSDARG00000089156 AllianceGenome:ZFIN:ZDB-GENE-040718-394
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:92020
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in hindbrain; myeloid cell; optic tectum; and telencephalon. Orthologous to human EGR3 (early growth response 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See egr3 in Genome Data Viewer
Location:
chromosome: 8
Exon count:
2
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (50727220..50733508)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (50738574..50744862)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene rho-related BTB domain-containing protein 2-like Neighboring gene phosphatidylethanolamine binding protein 4 Neighboring gene bridging integrator 3 Neighboring gene acyl-CoA synthetase long chain family member 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. A Structural Atlas of the Developing Zebrafish Telencephalon Based on Spatially-Restricted Transgene Expression. Turner KJ, et al. Front Neuroanat, 2022. PMID 35721460, Free PMC Article
  2. Dynamic regulation of VEGF-inducible genes by an ERK/ERG/p300 transcriptional network. Fish JE, et al. Development, 2017 Jul 1. PMID 28536097, Free PMC Article
  3. Common and specific downstream signaling targets controlled by Tlr2 and Tlr5 innate immune signaling in zebrafish. Yang S, et al. BMC Genomics, 2015 Jul 25. PMID 26208853, Free PMC Article
  4. Iroquois Homeobox 1 Acts as a True Tumor Suppressor in Multiple Organs by Regulating Cell Cycle Progression. Jung IH, et al. Neoplasia, 2019 Oct. PMID 31450023, Free PMC Article
  5. Active nuclear transcriptome analysis reveals inflammasome-dependent mechanism for early neutrophil response to Mycobacterium marinum. Kenyon A, et al. Sci Rep, 2017 Jul 26. PMID 28747644, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in anatomical structure morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in embryo development IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
early growth response protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002647.1 → NP_001002647.1  early growth response protein 3

    See identical proteins and their annotated locations for NP_001002647.1

    Status: PROVISIONAL

    Source sequence(s)
    BC076527
    UniProtKB/TrEMBL
    Q6DG27
    Related
    ENSDARP00000109921.1, ENSDART00000127062.3
    Conserved Domains (4) summary
    COG5048
    Location:325 → 405
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:299 → 321
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam11928
    Location:88 → 158
    DUF3446; Domain of unknown function (DUF3446)
    pfam13465
    Location:341 → 366
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    50727220..50733508
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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