gc GC vitamin D binding protein [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gcprovided by ZNC
Official Full Name: GC vitamin D binding proteinprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040718-307
See related: Ensembl:ENSDARG00000089310 AllianceGenome:ZFIN:ZDB-GENE-040718-307
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:92753; zgc:110389
Summary: Predicted to enable vitamin D binding activity. Predicted to act upstream of or within vitamin transport. Predicted to be located in extracellular space. Predicted to be active in cytoplasm. Is expressed in kidney; liver; and testis. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); hepatitis C; hepatobiliary system cancer (multiple); middle cerebral artery infarction; and rheumatic fever. Orthologous to several human genes including GC (GC vitamin D binding protein). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (45677786..45724836)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (45077633..45124683)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables vitamin D binding	IBA Inferred from Biological aspect of Ancestor more info
enables vitamin D binding	IEA Inferred from Electronic Annotation more info
enables vitamin transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within vitamin transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: vitamin D-binding protein

Names: dbp; group-specific component (vitamin D binding protein)

NP_001002568.2

EC 6.3.1.5

EC 6.4.-.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002568.2 → NP_001002568.2 vitamin D-binding protein precursor

Status: VALIDATED

Source sequence(s)

EH483827, EH491502, EH498309, EH517835, EH524589, FO744878, FP074860, FP245545

UniProtKB/TrEMBL

A0A0R4ITN2, A0A8M1N0S6

Related

ENSDARP00000106674.3, ENSDART00000126537.3

Conserved Domains (2) summary

pfam00273
Location:28 → 200

Serum_albumin; Serum albumin family

cl00031
Location:244 → 391

ALBUMIN; Albumin domain, contains five or six internal disulphide bonds; albuminoid superfamily includes alpha-fetoprotein which binds various cations, fatty acids and bilirubin; vitamin D-binding protein which binds to vitamin D, its metabolites, and fatty acids; ...