dnase1l1l deoxyribonuclease I-like 1-like [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dnase1l1lprovided by ZNC
Official Full Name: deoxyribonuclease I-like 1-likeprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040718-100
See related: Ensembl:ENSDARG00000023861 AllianceGenome:ZFIN:ZDB-GENE-040718-100
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: dnase1l3l; zgc:92699
Summary: Predicted to enable DNA binding activity and deoxyribonuclease I activity. Acts upstream of or within lens fiber cell differentiation and retina development in camera-type eye. Predicted to be active in nucleus. Is expressed in eye; lens; lens epithelium; and solid lens vesicle. Orthologous to human DNASE1L1 (deoxyribonuclease 1 like 1). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 8

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	8	NC_133183.1 (27249314..27254642)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (25351983..25357259)

Chromosome 8 - NC_133183.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knockout of DNase1l1l abrogates lens denucleation process and causes cataract in zebrafish.
Title: Knockout of DNase1l1l abrogates lens denucleation process and causes cataract in zebrafish.
Data show that dnase1l3l plays major roles in nuclear degradation in lens development.
Title: Critical roles of DNase1l3l in lens nuclear degeneration in zebrafish.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables DNA nuclease activity	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables deoxyribonuclease I activity	IBA Inferred from Biological aspect of Ancestor more info
enables endonuclease activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables nuclease activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within DNA catabolic process	IEA Inferred from Electronic Annotation more info
involved_in DNA metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lens development in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lens fiber cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within retina development in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: deoxyribonuclease I-like 1-like

Names: deoxyribonuclease I-like 3, like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.