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tspan4a tetraspanin 4a [ Danio rerio (zebrafish) ]

Gene ID: 436620, updated on 9-Sep-2025
Official Symbol
tspan4aprovided by ZNC
Official Full Name
tetraspanin 4aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040718-38
See related
Ensembl:ENSDARG00000089354 AllianceGenome:ZFIN:ZDB-GENE-040718-38
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:92174
Summary
Acts upstream of or within with a positive effect on organelle assembly. Acts upstream of or within Kupffer's vesicle development and localization of cell. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human TSPAN4 (tetraspanin 4). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
human mouse all
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See tspan4a in Genome Data Viewer
Location:
chromosome: 18
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 18 NC_133193.1 (54150002..54173253, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 18 NC_007129.7 (50801307..50826393)

Chromosome 18 - NC_133193.1Genomic Context describing neighboring genes Neighboring gene pyruvate dehydrogenase phosphatase regulatory subunit Neighboring gene damage-specific DNA binding protein 1 Neighboring gene uncharacterized LOC137488355 Neighboring gene uncharacterized LOC137488356 Neighboring gene transaldolase 1

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Migrasomes provide regional cues for organ morphogenesis during zebrafish gastrulation. Jiang D, et al. Nat Cell Biol, 2019 Aug. PMID 31371827
  2. Combination of reverse and chemical genetic screens reveals angiogenesis inhibitors and targets. Kalén M, et al. Chem Biol, 2009 Apr 24. PMID 19389629, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within_positive_effect organelle assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
tetraspanin-4a

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002348.1 → NP_001002348.1  tetraspanin-4a

    See identical proteins and their annotated locations for NP_001002348.1

    Status: PROVISIONAL

    Source sequence(s)
    BC075913
    UniProtKB/TrEMBL
    A0A1L1QZT1, A0A8M1N0A2, Q6DHQ4
    Related
    ENSDARP00000143203.2, ENSDART00000174126.2
    Conserved Domains (2) summary
    cd03165
    Location:107 → 202
    NET-5_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
    pfam00335
    Location:9 → 229
    Tetraspannin; Tetraspanin family

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133193.1 Reference GRCz12tu Primary Assembly

    Range
    54150002..54173253 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_073929023.1 → XP_073785124.1  tetraspanin-4a isoform X4

  2. XM_073929024.1 → XP_073785125.1  tetraspanin-4a isoform X5

  3. XM_073929021.1 → XP_073785122.1  tetraspanin-4a isoform X2

  4. XM_073929022.1 → XP_073785123.1  tetraspanin-4a isoform X3

    UniProtKB/TrEMBL
    A0A8M3AV73

  5. XM_073929019.1 → XP_073785120.1  tetraspanin-4a isoform X1

    UniProtKB/TrEMBL
    A0A8M3B373

  6. XM_073929020.1 → XP_073785121.1  tetraspanin-4a isoform X2

Nucleotide Protein Strain
Heading Accession and Version

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