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folt-3 Folate-like transporter 3 [ Caenorhabditis elegans ]

Gene ID: 4363081, updated on 2-Dec-2025
Official Symbol
folt-3
Official Full Name
Folate-like transporter 3
Primary source
WormBase:WBGene00044738
Locus tag
CELE_C50E3.16
See related
AllianceGenome:WB:WBGene00044738
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable folic acid binding activity and vitamin transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Used to study biotin-responsive basal ganglia disease. Human ortholog(s) of this gene implicated in biotin-responsive basal ganglia disease. Orthologous to human SLC19A3 (solute carrier family 19 member 3). [provided by Alliance of Genome Resources, Jul 2025]
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Location:
chromosome: V
Exon count:
6
Sequence:
Chromosome: V; NC_003283.11 (7603735..7609748, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene SCP domain-containing protein Neighboring gene uncharacterized protein Neighboring gene C-type LECtin Neighboring gene C-type lectin domain-containing protein Neighboring gene PAN-3 domain-containing protein

Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Mediator subunit MDT-15 promotes expression of propionic acid breakdown genes to prevent embryonic lethality in Caenorhabditis elegans. Goh GYS, et al. G3 (Bethesda), 2023 Jun 1. PMID 37075089, Free PMC Article
  2. Screening for cold tolerance genes in C. elegans, whose expressions are affected by anticancer drugs camptothecin and leptomycin B. Okahata M, et al. Sci Rep, 2024 Mar 5. PMID 38443452, Free PMC Article
  3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables folic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables vitamin transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vitamin transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vitamin transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
Folate-like transporter 3
NP_001041097.2
  • Confirmed by transcript evidence

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    7603735..7609748 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001047632.4 → NP_001041097.2  Folate-like transporter 3

    See identical proteins and their annotated locations for NP_001041097.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A7LPE0, Q22931
    Conserved Domains (1) summary
    pfam01770
    Location:2 → 394
    Folate_carrier; Reduced folate carrier
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q22931.3

Gene LinkOut

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