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aralar1 aralar1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43616, updated on 8-Feb-2025

Summary

Official Symbol
aralar1provided by FlyBase
Official Full Name
aralar1provided by FlyBase
Primary source
FLYBASE:FBgn0028646
Locus tag
Dmel_CG2139
See related
AllianceGenome:FB:FBgn0028646
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
aralar; Aralar; Aralar1; BcDNA:GH07418; CABP1; CG2139; DmAralar; Dmel\CG2139
Summary
Enables aspartate:glutamate, proton antiporter activity and gamma-aminobutyric acid:proton symporter activity. Involved in carboxylic acid transport and malate-aspartate shuttle. Located in mitochondrion. Is expressed in several structures, including adult head; adult heart; amnioserosa; embryonic proventriculus; and germline cell. Used to study neonatal-onset type II citrullinemia. Human ortholog(s) of this gene implicated in Asperger syndrome; adult-onset type II citrullinemia; autistic disorder; developmental and epileptic encephalopathy 39; and neonatal-onset type II citrullinemia. Orthologous to several human genes including SLC25A12 (solute carrier family 25 member 12). [provided by Alliance of Genome Resources, Feb 2025]
Orthologs
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Genomic context

See aralar1 in Genome Data Viewer
Location:
99F4-99F5; 3-100 cM
Exon count:
13
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (30445635..30455867, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (26271357..26281589, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Osiris 23 Neighboring gene uncharacterized protein Neighboring gene Ceramidase

Genomic regions, transcripts, and products

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables L-aspartate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables L-glutamate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables aspartate:glutamate, proton antiporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables calcium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables gamma-aminobutyric acid:proton symporter activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables identical protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in L-aspartate transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in L-glutamate transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in L-glutamate transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in aspartate transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in gamma-aminobutyric acid transport IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in gluconeogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in malate-aspartate shuttle IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in malate-aspartate shuttle IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in mitochondrial calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in wound healing HMP PubMed 

General protein information

Preferred Names
aralar1
Names
Aralar1
CG2139-PA
CG2139-PB
CG2139-PC
CG2139-PD
CG2139-PE
CG2139-PF
aralar1-PA
aralar1-PB
aralar1-PC
aralar1-PD
aralar1-PE
aralar1-PF

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    30445635..30455867 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_170485.2NP_733364.1  aralar1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733364.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V3N6, Q95TN5, Q9U5V8, Q9VA72, Q9VA73, Q9VA74
    UniProtKB/TrEMBL
    D0IQH2
    Related
    FBpp0085054
    Conserved Domains (5) summary
    PTZ00169
    Location:346619
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:338436
    Mito_carr; Mitochondrial carrier protein
    pfam13499
    Location:3599
    EF-hand_7; EF-hand domain pair
    pfam13833
    Location:5199
    EF-hand_8; EF-hand domain pair
    cl08302
    Location:84135
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  2. NM_001260439.1NP_001247368.1  aralar1, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247368.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K6V1, D0IQH2
    Conserved Domains (5) summary
    PTZ00169
    Location:358631
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:350448
    Mito_carr; Mitochondrial carrier protein
    pfam13499
    Location:3599
    EF-hand_7; EF-hand domain pair
    pfam13833
    Location:5199
    EF-hand_8; EF-hand domain pair
    cl08302
    Location:84135
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  3. NM_170487.3NP_733366.2  aralar1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733366.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    D0IQH2
    Related
    FBpp0085055
    Conserved Domains (5) summary
    PTZ00169
    Location:330603
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:322420
    Mito_carr; Mitochondrial carrier protein
    pfam13499
    Location:1983
    EF-hand_7; EF-hand domain pair
    pfam13833
    Location:3583
    EF-hand_8; EF-hand domain pair
    cl08302
    Location:68119
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  4. NM_143538.3NP_651795.2  aralar1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651795.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    D0IQH2
    Related
    FBpp0085056
    Conserved Domains (5) summary
    PTZ00169
    Location:333606
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:325423
    Mito_carr; Mitochondrial carrier protein
    pfam13499
    Location:2286
    EF-hand_7; EF-hand domain pair
    pfam13833
    Location:3886
    EF-hand_8; EF-hand domain pair
    cl08302
    Location:71122
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  5. NM_001276178.1NP_001263107.1  aralar1, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001263107.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KHW3, D0IQH2
    Conserved Domains (5) summary
    PTZ00169
    Location:333606
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:325423
    Mito_carr; Mitochondrial carrier protein
    pfam13499
    Location:2286
    EF-hand_7; EF-hand domain pair
    pfam13833
    Location:3886
    EF-hand_8; EF-hand domain pair
    cl08302
    Location:71122
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  6. NM_170486.2NP_733365.1  aralar1, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733365.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D0IQH2
    Related
    FBpp0085057
    Conserved Domains (5) summary
    PTZ00169
    Location:333606
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:325423
    Mito_carr; Mitochondrial carrier protein
    pfam13499
    Location:2286
    EF-hand_7; EF-hand domain pair
    pfam13833
    Location:3886
    EF-hand_8; EF-hand domain pair
    cl08302
    Location:71122
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...