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Lrp3 low density lipoprotein receptor-related protein 3 [ Mus musculus (house mouse) ]

Gene ID: 435965, updated on 6-Jun-2024

Summary

Official Symbol
Lrp3provided by MGI
Official Full Name
low density lipoprotein receptor-related protein 3provided by MGI
Primary source
MGI:MGI:3584516
See related
Ensembl:ENSMUSG00000001802 AllianceGenome:MGI:3584516
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to be involved in negative regulation of fat cell differentiation; positive regulation of osteoblast differentiation; and regulation of gene expression. Predicted to be active in plasma membrane. Orthologous to human LRP3 (LDL receptor related protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in whole brain E14.5 (RPKM 26.3), CNS E14 (RPKM 25.1) and 21 other tissues See more
Orthologs
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Genomic context

See Lrp3 in Genome Data Viewer
Location:
7 B2; 7 21.15 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (34900303..34914770, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (35200878..35217392, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35889 Neighboring gene predicted gene, 38988 Neighboring gene solute carrier family 7 (cationic amino acid transporter, y+ system), member 10 Neighboring gene predicted gene, 24505 Neighboring gene predicted gene, 38989 Neighboring gene nuclear encoded tRNA threonine 9 (anticodon AGT)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General protein information

Preferred Names
low-density lipoprotein receptor-related protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024707.2NP_001019878.1  low-density lipoprotein receptor-related protein 3 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AK149314, BC094349, CJ106421
    Consensus CDS
    CCDS52202.1
    UniProtKB/TrEMBL
    E9Q1T6, Q3UEV4
    Related
    ENSMUSP00000114026.2, ENSMUST00000122409.8
    Conserved Domains (2) summary
    cd00041
    Location:64177
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00112
    Location:187221
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
  2. NM_001421534.1NP_001408463.1  low-density lipoprotein receptor-related protein 3 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC150683
    UniProtKB/TrEMBL
    E9Q711, Q3UEV4
    Related
    ENSMUSP00000113406.2, ENSMUST00000118444.3

RNA

  1. NR_185310.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC150683

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    34900303..34914770 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)