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spn-A spindle A [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43577, updated on 4-Nov-2018

Summary

Official Symbol
spn-Aprovided by FlyBase
Official Full Name
spindle Aprovided by FlyBase
Primary source
FLYBASE:FBgn0003479
Locus tag
Dmel_CG7948
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster (old-lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG7948; D37788; Dm Rad51; Dmel\CG7948; DMR; DMR/DroRAD51; DMR1; dmrad51; dmRAD51; Dmrad51; DmRad51; DmRAD51; RA51; RA51_DROME; rad51; Rad51; RAD51; Rad51dm; Spn-A; spnA; SpnA

Genomic context

See spn-A in Genome Data Viewer
Location:
99D3-99D3; 3-100 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.13 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (30054696..30056037, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25880418..25881759, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene similar Neighboring gene ncRNA

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the spn-A gene: The spn-A gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
DNA-dependent ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
recombinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
recombinase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
DNA recombinase assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA recombination ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
DNA repair IGI
Inferred from Genetic Interaction
more info
PubMed 
DNA repair ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
chromosome organization involved in meiotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
double-strand break repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
double-strand break repair via synthesis-dependent strand annealing IMP
Inferred from Mutant Phenotype
more info
PubMed 
female meiotic nuclear division IMP
Inferred from Mutant Phenotype
more info
PubMed 
germarium-derived oocyte fate determination IGI
Inferred from Genetic Interaction
more info
PubMed 
intracellular mRNA localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular mRNA localization TAS
Traceable Author Statement
more info
PubMed 
mitotic recombination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic recombination-dependent replication fork processing IEA
Inferred from Electronic Annotation
more info
 
oocyte fate determination IMP
Inferred from Mutant Phenotype
more info
PubMed 
oocyte karyosome formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
oogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
oogenesis TAS
Traceable Author Statement
more info
PubMed 
polarity specification of anterior/posterior axis IMP
Inferred from Mutant Phenotype
more info
PubMed 
polarity specification of dorsal/ventral axis IMP
Inferred from Mutant Phenotype
more info
PubMed 
reciprocal meiotic recombination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of double-strand break repair via homologous recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to caffeine IGI
Inferred from Genetic Interaction
more info
PubMed 
strand invasion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
condensed nuclear chromosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
spindle A
Names
CG7948-PA
CG7948-PB
Rad51-like
Spindle-A
spn-A-PA
spn-A-PB
NP_524583.1
NP_733342.1

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    30054696..30056037 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079844.4NP_524583.1  spindle A, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524583.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q27297
    UniProtKB/TrEMBL
    C6SV45
    Related
    FBpp0084955, FBtr0085589
    Conserved Domains (3) summary
    cd01123
    Location:99331
    Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...
    TIGR02239
    Location:22335
    recomb_RAD51; DNA repair protein RAD51
    pfam14520
    Location:3077
    HHH_5; Helix-hairpin-helix domain
  2. NM_170463.3NP_733342.1  spindle A, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733342.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q27297
    Related
    FBpp0084956, FBtr0085590
    Conserved Domains (2) summary
    cd01123
    Location:42274
    Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...
    pfam08423
    Location:24277
    Rad51; Rad51
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