Format

Send to:

Choose Destination

MPI mannose phosphate isomerase [ Homo sapiens (human) ]

Gene ID: 4351, updated on 17-Jun-2019

Summary

Official Symbol
MPIprovided by HGNC
Official Full Name
mannose phosphate isomeraseprovided by HGNC
Primary source
HGNC:HGNC:7216
See related
Ensembl:ENSG00000178802 MIM:154550
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PMI; PMI1; CDG1B
Summary
Phosphomannose isomerase catalyzes the interconversion of fructose-6-phosphate and mannose-6-phosphate and plays a critical role in maintaining the supply of D-mannose derivatives, which are required for most glycosylation reactions. Mutations in the MPI gene were found in patients with carbohydrate-deficient glycoprotein syndrome, type Ib. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Expression
Ubiquitous expression in duodenum (RPKM 9.9), small intestine (RPKM 9.3) and 25 other tissues See more
Orthologs

Genomic context

See MPI in Genome Data Viewer
Location:
15q24.1
Exon count:
8
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (74890042..74902219)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (75182377..75190581)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene microRNA 6882 Neighboring gene unc-51 like kinase 3 Neighboring gene secretory carrier membrane protein 2 Neighboring gene family with sequence similarity 219 member B Neighboring gene cytochrome c oxidase subunit 5A Neighboring gene ribonuclease P and MRP subunit p25

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of mannose phosphate isomerase (MPI) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

  • Homologs of the MPI gene: The MPI gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
  • Orthologs from Annotation Pipeline: 265 organisms have orthologs with human gene MPI
  • Orthologs

Clone Names

  • FLJ39201

Gene Ontology Provided by GOA

Function Evidence Code Pubs
mannose-6-phosphate isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mannose-6-phosphate isomerase activity TAS
Traceable Author Statement
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
GDP-mannose biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GDP-mannose biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
GDP-mannose biosynthetic process TAS
Traceable Author Statement
more info
 
cell wall mannoprotein biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mannose to fructose-6-phosphate metabolic process IEA
Inferred from Electronic Annotation
more info
 
protein glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 

General protein information

Preferred Names
mannose-6-phosphate isomerase
Names
phosphohexomutase
phosphomannose isomerase 1
NP_001276084.1
NP_001276085.1
NP_001276086.1
NP_001317301.1
NP_002426.1
XP_016877697.1
XP_016877698.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008921.1 RefSeqGene

    Range
    4943..14389
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001289155.2NP_001276084.1  mannose-6-phosphate isomerase isoform 2

    See identical proteins and their annotated locations for NP_001276084.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compare to isoform 1.
    Source sequence(s)
    AC125435, AF504648, AW445009, AW813817, BX648475, CD706167
    Consensus CDS
    CCDS73756.1
    UniProtKB/TrEMBL
    H3BPP3, Q8NHZ6
    Related
    ENSP00000455405.1, ENST00000566377.5
    Conserved Domains (1) summary
    pfam01238
    Location:6281
    PMI_typeI; Phosphomannose isomerase type I
  2. NM_001289156.2NP_001276085.1  mannose-6-phosphate isomerase isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks part of the 5' coding region, and uses a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC125435, AK301370, AW445009, AW813817, BC046357, BX648475
    Consensus CDS
    CCDS73758.1
    UniProtKB/Swiss-Prot
    P34949
    UniProtKB/TrEMBL
    B4DW50, F5GX71
    Related
    ENSP00000440447.1, ENST00000535694.5
    Conserved Domains (1) summary
    pfam01238
    Location:1332
    PMI_typeI; Phosphomannose isomerase type I
  3. NM_001289157.2NP_001276086.1  mannose-6-phosphate isomerase isoform 4

    See identical proteins and their annotated locations for NP_001276086.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (4) is shorter, compared to isoform 1.
    Source sequence(s)
    AC125435, AW445009, AW813817, BC017351, BX648475, CD706167
    Consensus CDS
    CCDS73757.1
    UniProtKB/Swiss-Prot
    P34949
    Related
    ENSP00000318192.6, ENST00000323744.10
    Conserved Domains (1) summary
    pfam01238
    Location:6321
    PMI_typeI; Phosphomannose isomerase type I
  4. NM_001330372.2NP_001317301.1  mannose-6-phosphate isomerase isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site, resulting in a distinct 5' UTR and the use of a downstream start codon, compared to variant 1. The encoded isoform (5) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC125435, AW445009
    Consensus CDS
    CCDS81908.1
    UniProtKB/TrEMBL
    H3BPB8
    Related
    ENSP00000455241.1, ENST00000563786.5
    Conserved Domains (2) summary
    COG1482
    Location:23399
    ManA; Mannose-6-phosphate isomerase, class I [Carbohydrate transport and metabolism]
    pfam01238
    Location:1362
    PMI_typeI; Phosphomannose isomerase type I
  5. NM_002435.3NP_002426.1  mannose-6-phosphate isomerase isoform 1

    See identical proteins and their annotated locations for NP_002426.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC125435, AW445009, AW813817, BC046357, BX648475, CD706167
    Consensus CDS
    CCDS10272.1
    UniProtKB/Swiss-Prot
    P34949
    Related
    ENSP00000318318.6, ENST00000352410.9
    Conserved Domains (2) summary
    COG1482
    Location:9419
    ManA; Mannose-6-phosphate isomerase, class I [Carbohydrate transport and metabolism]
    pfam01238
    Location:6382
    PMI_typeI; Phosphomannose isomerase type I

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    74890042..74902219
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017022208.1XP_016877697.1  mannose-6-phosphate isomerase isoform X1

    UniProtKB/TrEMBL
    Q8NHZ6
    Related
    ENSP00000455161.1, ENST00000569931.5
    Conserved Domains (1) summary
    pfam01238
    Location:1261
    PMI_typeI; Phosphomannose isomerase type I
  2. XM_017022209.2XP_016877698.1  mannose-6-phosphate isomerase isoform X2

Support Center