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Naa40 N(alpha)-acetyltransferase 40 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43500, updated on 5-Jul-2025
Official Symbol
Naa40provided by FlyBase
Official Full Name
N(alpha)-acetyltransferase 40provided by FlyBase
Primary source
FLYBASE:FBgn0039687
Locus tag
Dmel_CG7593
See related
AllianceGenome:FB:FBgn0039687
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG7593; Dmel\CG7593
Summary
Predicted to enable histone H2A acetyltransferase activity; histone H4 acetyltransferase activity; and protein N-terminal-serine acetyltransferase activity. Predicted to be active in nucleus. Is expressed in dorsal ectoderm anlage; mesoderm anlage; organism; and ventral ectoderm anlage. Orthologous to human NAA40 (N-alpha-acetyltransferase 40, NatD catalytic subunit). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See Naa40 in Genome Data Viewer
Location:
99B9-99B9; 3-99 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29724159..29724950, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25549881..25550672, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR46108 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene pterin-4a-carbinolamine dehydratase Neighboring gene uncharacterized protein Neighboring gene Kuzbanian-like Neighboring gene uncharacterized protein

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Histone acetyltransferase NAA40 modulates acetyl-CoA levels and lipid synthesis. Charidemou E, et al. BMC Biol, 2022 Jan 20. PMID 35057804, Free PMC Article
  2. Effective but costly, evolved mechanisms of defense against a virulent opportunistic pathogen in Drosophila melanogaster. Ye YH, et al. PLoS Pathog, 2009 Apr. PMID 19381251, Free PMC Article
  3. Absence of N-terminal acetyltransferase diversification during evolution of eukaryotic organisms. Rathore OS, et al. Sci Rep, 2016 Feb 10. PMID 26861501, Free PMC Article
  4. Mitochondrial-Nuclear Interactions Mediate Sex-Specific Transcriptional Profiles in Drosophila. Mossman JA, et al. Genetics, 2016 Oct. PMID 27558138, Free PMC Article
  5. Endogenously imprinted genes in Drosophila melanogaster. McEachern LA, et al. Mol Genet Genomics, 2014 Aug. PMID 24658702

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
Inferred from Electronic Annotation
more info
  
enables histone H2A acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H2A acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H4 acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H4 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein N-terminal-serine acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-N-terminal amino-acid acetyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
N(alpha)-acetyltransferase 40
Names
CG7593-PA
Naa40-PA
Ubiquinol-cytochrome C reductase complex 11 kDa protein
NP_651715.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    29724159..29724950 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143458.3 → NP_651715.1  N(alpha)-acetyltransferase 40

    See identical proteins and their annotated locations for NP_651715.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VAI4
    Related
    FBpp0084827
    Conserved Domains (1) summary
    pfam00583
    Location:106 → 179
    Acetyltransf_1; Acetyltransferase (GNAT) family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VAI4 Q9VAI4

Gene LinkOut

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