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CG14507 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43461, updated on 4-Jan-2025

Summary

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Official Symbol
CG14507provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0039655
Locus tag
Dmel_CG14507
See related
AllianceGenome:FB:FBgn0039655
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG14507
Summary
Predicted to enable calcium-dependent phospholipase A2 activity. Predicted to be involved in arachidonate secretion; lipid catabolic process; and phospholipid metabolic process. Human ortholog(s) of this gene implicated in cholecystolithiasis; colorectal cancer; familial benign fleck retina; gastroesophageal reflux disease; and human immunodeficiency virus infectious disease. Orthologous to several human genes including PLA2G2A (phospholipase A2 group IIA); PLA2G2D (phospholipase A2 group IID); and PLA2G2E (phospholipase A2 group IIE). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See CG14507 in Genome Data Viewer
Location:
99A1-99A1; 3-98 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29226204..29227725, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25051926..25053447, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene eukaryotic translation elongation factor 1 gamma Neighboring gene CDGSH iron sulfur domain 2 Neighboring gene Bromodomain containing 8 Neighboring gene Ubiquitin specific protease 1 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Gene induction following wounding of wild-type versus macrophage-deficient Drosophila embryos. Stramer B, et al. EMBO Rep, 2008 May. PMID 18344972, Free PMC Article
  2. Clotting factors and eicosanoids protect against nematode infections. Hyrsl P, et al. J Innate Immun, 2011. PMID 20948189
  3. Drosophila Fed ARA and EPA Yields Eicosanoids, 15S-Hydroxy-5Z,8Z, 11Z, 13E-Eicosatetraenoic Acid, and 15S-Hydroxy-5Z,8Z,11Z,13E,17Z-Eicosapentaenoic Acid. Tan L, et al. Lipids, 2016 Apr. PMID 26931457
  4. Drosophila spermatid individualization is sensitive to temperature and fatty acid metabolism. Ben-David G, et al. Spermatogenesis, 2015 Jan-Apr. PMID 26413411, Free PMC Article
  5. Chemical screen reveals small molecules suppressing fragile X premutation rCGG repeat-mediated neurodegeneration in Drosophila. Qurashi A, et al. Hum Mol Genet, 2012 May 1. PMID 22298836, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium-dependent phospholipase A2 activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phospholipase A2 activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in arachidonate secretion IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid metabolic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG14507-PC
NP_001097964.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    29226204..29227725 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001104494.2 → NP_001097964.1  uncharacterized protein Dmel_CG14507 [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    B3DND2, Q8IML0
    Conserved Domains (1) summary
    cd00125
    Location:243 → 357
    PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IML0 Q8IML0

Gene LinkOut

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