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Iho1 interactor of HORMAD1 1 [ Mus musculus (house mouse) ]

Gene ID: 434438, updated on 26-Sep-2022

Summary

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Official Symbol
Iho1provided by MGI
Official Full Name
interactor of HORMAD1 1provided by MGI
Primary source
MGI:MGI:3612242
See related
Ensembl:ENSMUSG00000047220 AllianceGenome:MGI:3612242
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ccdc36
Summary
Involved in gamete generation; meiosis I cell cycle process; and regulation of homologous chromosome segregation. Located in condensed nuclear chromosome. Is expressed in alimentary system; central nervous system; lung; temporal bone petrous part; and testis. Orthologous to human IHO1 (interactor of HORMAD1 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 1.9), CNS E18 (RPKM 0.6) and 6 other tissues See more
Orthologs
human all
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Genomic context

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See Iho1 in Genome Data Viewer
Location:
9; 9 F2
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (108280691..108309040, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (108403492..108431841, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 4 (proto-oncogene) Neighboring gene ribosomal protein S2, pseudogene 11 Neighboring gene RIKEN cDNA 1700102P08 gene Neighboring gene predicted gene, 25456 Neighboring gene cDNA sequence BC048562 Neighboring gene kelch domain containing 8B Neighboring gene coiled-coil domain containing 71 Neighboring gene microRNA 12206

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mouse ANKRD31 Regulates Spatiotemporal Patterning of Meiotic Recombination Initiation and Ensures Recombination between X and Y Sex Chromosomes. Papanikos F, et al. Mol Cell, 2019 Jun 6. PMID 31000436
  2. Mouse REC114 is essential for meiotic DNA double-strand break formation and forms a complex with MEI4. Kumar R, et al. Life Sci Alliance, 2018 Dec. PMID 30569039, Free PMC Article
  3. Meiotic DNA break formation requires the unsynapsed chromosome axis-binding protein IHO1 (CCDC36) in mice. Stanzione M, et al. Nat Cell Biol, 2016 Nov. PMID 27723721, Free PMC Article
  4. SCF ubiquitin E3 ligase regulates DNA double-strand breaks in early meiotic recombination. Guan Y, et al. Nucleic Acids Res, 2022 May 20. PMID 35489071, Free PMC Article
  5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

See all (11) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA recombination IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA recombination IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in homologous chromosome pairing at meiosis IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in homologous chromosome pairing at meiosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic DNA double-strand break formation IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in meiotic DNA double-strand break formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in oogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of homologous chromosome segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in condensed nuclear chromosome IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in condensed nuclear chromosome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
interactor of HORMAD1 protein 1
Names
coiled-coil domain containing 36
coiled-coil domain-containing protein 36

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135198.2 → NP_001128670.1  interactor of HORMAD1 protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001128670.1

    Status: VALIDATED

    Source sequence(s)
    AC161260
    Consensus CDS
    CCDS57701.1
    UniProtKB/Swiss-Prot
    Q6PDM4
    Related
    ENSMUSP00000075898.3, ENSMUST00000076592.4
    Conserved Domains (1) summary
    pfam15771
    Location:19 → 572
    IHO1; Interactor of HORMAD1 protein 1

  2. NM_001379658.1 → NP_001366587.1  interactor of HORMAD1 protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC161260
    UniProtKB/Swiss-Prot
    Q6PDM4
    Conserved Domains (1) summary
    pfam15771
    Location:19 → 572
    IHO1; Interactor of HORMAD1 protein 1

  3. NM_001411369.1 → NP_001398298.1  interactor of HORMAD1 protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC161260

  4. NM_001411370.1 → NP_001398299.1  interactor of HORMAD1 protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC161260

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    108280691..108309040 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011242895.2 → XP_011241197.1  interactor of HORMAD1 protein 1 isoform X1

    Conserved Domains (1) summary
    pfam15771
    Location:20 → 495
    IHO1; Interactor of HORMAD1 protein 1

  2. XM_011242896.2 → XP_011241198.1  interactor of HORMAD1 protein 1 isoform X2

    See identical proteins and their annotated locations for XP_011241198.1

    Conserved Domains (1) summary
    pfam15771
    Location:1 → 385
    IHO1; Interactor of HORMAD1 protein 1

  3. XM_006511766.4 → XP_006511829.1  interactor of HORMAD1 protein 1 isoform X2

    Conserved Domains (1) summary
    pfam15771
    Location:1 → 385
    IHO1; Interactor of HORMAD1 protein 1

  4. XM_036155100.1 → XP_036010993.1  interactor of HORMAD1 protein 1 isoform X2

    Conserved Domains (1) summary
    pfam15771
    Location:1 → 385
    IHO1; Interactor of HORMAD1 protein 1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PDM4.3 GenPept UniProtKB/Swiss-Prot:Q6PDM4

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