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MOV10 Mov10 RISC complex RNA helicase [ Homo sapiens (human) ]

Gene ID: 4343, updated on 4-Nov-2018

Summary

Official Symbol
MOV10provided by HGNC
Official Full Name
Mov10 RISC complex RNA helicaseprovided by HGNC
Primary source
HGNC:HGNC:7200
See related
Ensembl:ENSG00000155363 MIM:610742; Vega:OTTHUMG00000011906
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
gb110; fSAP113
Expression
Ubiquitous expression in placenta (RPKM 19.5), small intestine (RPKM 18.6) and 25 other tissues See more
Orthologs

Genomic context

See MOV10 in Genome Data Viewer
Location:
1p13.2
Exon count:
23
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (112674312..112702377)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (113217048..113243368)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene capping actin protein of muscle Z-line subunit alpha 1 Neighboring gene mitochondrial ribosomal protein L53 pseudogene 1 Neighboring gene RNA, U7 small nuclear 70 pseudogene Neighboring gene ras homolog family member C Neighboring gene uncharacterized LOC105378910 Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent 1J

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.
NHGRI GWA Catalog
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
NHGRI GWA Catalog
Genome-wide association study in Chinese identifies novel loci for blood pressure and hypertension.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
siRNA-mediated knockdown of endogeneous MOV10 impairs HIV-1 virus production and Gag expression in 293T cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify Moloney leukemia virus 10 homolog (MOV10), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify Moloney leukemia virus 10 homolog (MOV10), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify Moloney leukemia virus 10 homolog (MOV10), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag siRNA-mediated knockdown of endogeneous MOV10 impairs HIV-1 virus production and Gag expression in 293T cells PubMed
gag Tandem affinity purification and mass spectrometry analysis identify Moloney leukemia virus 10 homolog (MOV10), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
gag Overexpression of the Mov10 mutants, G681A/D682A and R730A/N731A, impairs Mov10-mediated decrease of HIV-1 Gag expression in cells and the incorporation efficiency of Mov10 into particles PubMed
gag The efficiency of incorporation of Mov10, A3G, and A3F into viral particles, which contains both HIV-1 Gag and genomic RNA, is much higher than that of the other P-body proteins AGO2, DCP1a, DCP2, and DDX6 PubMed
gag Mov10 overexpression results in translational repression of HIV-1 Gag and that AGO2 and/or RISC function is required to induce this translational repression PubMed
gag Overexpression of A3G and Mov10 decreases the efficiency of HIV-1 Gag processing in the virus-producing cells PubMed
gag MOV10 is packaged into HIV-1 virions in an RNA-dependent manner via an interaction with the NC domain of Gag PubMed
gag HIV-1 Gag binds to the N-terminal amino acids 261-305 region of MOV10. The seven helicase motifs of MOV10 are not required for its interaction with Gag, while all but one of them (motif V) are required for MOV10 packaging into virions PubMed
Rev rev HIV-1 Rev requires MOV10 helicase activity for enhanced function PubMed
rev HIV-1 Rev interacts with Rev PubMed
rev Rev/RRE expression is specifically upregulated by MOV10 in a Rev/RRE-dependent reprter gene assay PubMed
nucleocapsid gag MOV10 is packaged into HIV-1 virions in an RNA-dependent manner via an interaction with the NC domain of Gag PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Beta-catenin independent WNT signaling, organism-specific biosystem (from REACTOME)
    Beta-catenin independent WNT signaling, organism-specific biosystemHumans and mice have 19 identified WNT proteins that were originally classified as either 'canonical' or 'non-canonical' depending upon whether they were able to transform the mouse mammary epithelia...
  • Ca2+ pathway, organism-specific biosystem (from REACTOME)
    Ca2+ pathway, organism-specific biosystemA number of so called non-canonical WNT ligands have been shown to promote intracellular calcium release upon FZD binding. This beta-catenin-independent WNT pathway acts through heterotrimeric G pro...
  • Cellular Senescence, organism-specific biosystem (from REACTOME)
    Cellular Senescence, organism-specific biosystemCellular senescence involves irreversible growth arrest accompanied by phenotypic changes such as enlarged morphology, reorganization of chromatin through formation of senescence-associated heterochr...
  • Cellular responses to stress, organism-specific biosystem (from REACTOME)
    Cellular responses to stress, organism-specific biosystemCells are subject to external molecular and physical stresses such as foreign molecules that perturb metabolic or signaling processes, and changes in temperature or pH. The ability of cells and tissu...
  • DAP12 interactions, organism-specific biosystem (from REACTOME)
    DAP12 interactions, organism-specific biosystemDNAX activation protein of 12kDa (DAP12) is an immunoreceptor tyrosine-based activation motif (ITAM)-bearing adapter molecule that transduces activating signals in natural killer (NK) and myeloid cel...
  • DAP12 signaling, organism-specific biosystem (from REACTOME)
    DAP12 signaling, organism-specific biosystemIn response to receptor ligation, the tyrosine residues in DAP12's immunoreceptor tyrosine-based activation motif (ITAM) are phosphorylated by Src family kinases. These phosphotyrosines form the dock...
  • Downstream signal transduction, organism-specific biosystem (from REACTOME)
    Downstream signal transduction, organism-specific biosystemThe role of autophosphorylation sites on PDGF receptors are to provide docking sites for downstream signal transduction molecules which contain SH2 domains. The SH2 domain is a conserved motif of aro...
  • Downstream signaling events of B Cell Receptor (BCR), organism-specific biosystem (from REACTOME)
    Downstream signaling events of B Cell Receptor (BCR), organism-specific biosystemSecond messengers (calcium, diacylglycerol, inositol 1,4,5-trisphosphate, and phosphatidyinositol 3,4,5-trisphosphate) trigger signaling pathways: NF-kappaB is activated via protein kinase C beta, RA...
  • Fc epsilon receptor (FCERI) signaling, organism-specific biosystem (from REACTOME)
    Fc epsilon receptor (FCERI) signaling, organism-specific biosystemMast cells (MC) are distributed in tissues throughout the human body and have long been recognized as key cells of type I hypersensitivity reactions. They also play important roles in inflammatory an...
  • GAB1 signalosome, organism-specific biosystem (from REACTOME)
    GAB1 signalosome, organism-specific biosystemGAB1 is recruited to the activated EGFR indirectly, through GRB2. GAB1 acts as an adaptor protein that enables formation of an active PIK3, through recruitment of PIK3 regulatory subunit PIK3R1 (also...
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • MAPK family signaling cascades, organism-specific biosystem (from REACTOME)
    MAPK family signaling cascades, organism-specific biosystemThe mitogen activated protein kinases (MAPKs) are a family of conserved protein serine threonine kinases that respond to varied extracellular stimuli to activate intracellular processes including gen...
  • MAPK6/MAPK4 signaling, organism-specific biosystem (from REACTOME)
    MAPK6/MAPK4 signaling, organism-specific biosystemMAPK6 and MAPK4 (also known as ERK3 and ERK4) are vertebrate-specific atypical MAP kinases. Atypical MAPK are less well characterized than their conventional counterparts, and are generally classifi...
  • NGF signalling via TRKA from the plasma membrane, organism-specific biosystem (from REACTOME)
    NGF signalling via TRKA from the plasma membrane, organism-specific biosystemTrk receptors signal from the plasma membrane and from intracellular membranes, particularly from early endosomes. Signalling from the plasma membrane is fast but transient; signalling from endosomes...
  • Oncogene Induced Senescence, organism-specific biosystem (from REACTOME)
    Oncogene Induced Senescence, organism-specific biosystemOncogene-induced senescence is triggered by high level of RAS/RAF/MAPK signaling that can be caused, for example, by oncogenic mutations in RAS or RAF proteins, or by oncogenic mutations in growth fa...
  • Oxidative Stress Induced Senescence, organism-specific biosystem (from REACTOME)
    Oxidative Stress Induced Senescence, organism-specific biosystemOxidative stress, caused by increased concentration of reactive oxygen species (ROS) in the cell, can happen as a consequence of mitochondrial dysfunction induced by the oncogenic RAS (Moiseeva et al...
  • PI3K/AKT activation, organism-specific biosystem (from REACTOME)
    PI3K/AKT activation, organism-specific biosystemPI3K/AKT signalling is a major regulator of neuron survival. It blocks cell death by both impinging on the cytoplasmic cell death machinery and by regulating the expression of genes involved in cell...
  • PIP3 activates AKT signaling, organism-specific biosystem (from REACTOME)
    PIP3 activates AKT signaling, organism-specific biosystemSignaling by AKT is one of the key outcomes of receptor tyrosine kinase (RTK) activation. AKT is activated by the cellular second messenger PIP3, a phospholipid that is generated by PI3K. In ustimula...
  • Pre-NOTCH Expression and Processing, organism-specific biosystem (from REACTOME)
    Pre-NOTCH Expression and Processing, organism-specific biosystemIn humans and other mammals the NOTCH gene family has four members, NOTCH1, NOTCH2, NOTCH3 and NOTCH4, encoded on four different chromosomes. Their transcription is developmentally regulated and tiss...
  • Pre-NOTCH Transcription and Translation, organism-specific biosystem (from REACTOME)
    Pre-NOTCH Transcription and Translation, organism-specific biosystemIn humans, the NOTCH protein family has four members: NOTCH1, NOTCH2, NOTCH3 and NOTCH4. NOTCH1 protein was identified first, as the product of a chromosome 9 gene translocated in T-cell acute lympho...
  • Role of LAT2/NTAL/LAB on calcium mobilization, organism-specific biosystem (from REACTOME)
    Role of LAT2/NTAL/LAB on calcium mobilization, organism-specific biosystemThe lipid raft resident adaptor molecules LAT1 and Non-T cell activation linker (NTAL), also known as linker for activation of B cells (LAB)/LAT2 are known participants in the regulation of mast cell...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by EGFR, organism-specific biosystem (from REACTOME)
    Signaling by EGFR, organism-specific biosystemThe epidermal growth factor receptor (EGFR) is one member of the ERBB family of transmembrane glycoprotein tyrosine receptor kinases (RTK). Binding of EGFR to its ligands induces conformational chang...
  • Signaling by NOTCH, organism-specific biosystem (from REACTOME)
    Signaling by NOTCH, organism-specific biosystemThe Notch Signaling Pathway (NSP) is a highly conserved pathway for cell-cell communication. NSP is involved in the regulation of cellular differentiation, proliferation, and specification. For exam...
  • Signaling by PDGF, organism-specific biosystem (from REACTOME)
    Signaling by PDGF, organism-specific biosystemPlatelet-derived Growth Factor (PDGF) is a potent stimulator of growth and motility of connective tissue cells such as fibroblasts and smooth muscle cells as well as other cells such as capillary end...
  • Signaling by SCF-KIT, organism-specific biosystem (from REACTOME)
    Signaling by SCF-KIT, organism-specific biosystemStem cell factor (SCF) is a growth factor with membrane bound and soluble forms. It is expressed by fibroblasts and endothelial cells throughout the body, promoting proliferation, migration, survival...
  • Signaling by Wnt, organism-specific biosystem (from REACTOME)
    Signaling by Wnt, organism-specific biosystemWNT signaling pathways control a wide range of developmental and adult process in metozoans including cell proliferation, cell fate decisions, cell polarity and stem cell maintenance (reviewed in Sai...
  • Signaling by the B Cell Receptor (BCR), organism-specific biosystem (from REACTOME)
    Signaling by the B Cell Receptor (BCR), organism-specific biosystemMature B cells express IgM and IgD immunoglobulins which are complexed at the plasma membrane with Ig-alpha (CD79A, MB-1) and Ig-beta (CD79B, B29) to form the B cell receptor (BCR) (Fu et al. 1974, F...
  • Signalling by NGF, organism-specific biosystem (from REACTOME)
    Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
  • TP53 Regulates Metabolic Genes, organism-specific biosystem (from REACTOME)
    TP53 Regulates Metabolic Genes, organism-specific biosystemWhile the p53 tumor suppressor protein (TP53) is known to inhibit cell growth by inducing apoptosis, senescence and cell cycle arrest, recent studies have found that p53 is also able to influence cel...
  • Transcriptional Regulation by TP53, organism-specific biosystem (from REACTOME)
    Transcriptional Regulation by TP53, organism-specific biosystemThe tumor suppressor TP53 (encoded by the gene p53) is a transcription factor. Under stress conditions, it recognizes specific responsive DNA elements and thus regulates the transcription of many gen...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ32791, KIAA1631, DKFZp667O1423

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATP-dependent 5'-3' RNA helicase activity IDA
Inferred from Direct Assay
more info
PubMed 
RNA binding HDA PubMed 
RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
P granule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
P-body IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic ribonucleoprotein granule IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular space HDA PubMed 

General protein information

Preferred Names
putative helicase MOV-10
Names
Mov10, Moloney leukemia virus 10, homolog
armitage homolog
functional spliceosome-associated protein 113
moloney leukemia virus 10 protein
NP_001123551.1
NP_001273001.1
NP_001308253.1
NP_066014.1
XP_005270926.1
XP_005270927.1
XP_016856807.1
XP_016856808.1
XP_024302900.1
XP_024302905.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130079.2NP_001123551.1  putative helicase MOV-10 isoform 1

    See identical proteins and their annotated locations for NP_001123551.1

    Status: VALIDATED

    Source sequence(s)
    AK226011, AL603832, BU623853
    Consensus CDS
    CCDS853.1
    UniProtKB/Swiss-Prot
    Q9HCE1
    Conserved Domains (2) summary
    pfam13087
    Location:698922
    AAA_12; AAA domain
    cl26261
    Location:485944
    AAA_11; AAA domain
  2. NM_001286072.1NP_001273001.1  putative helicase MOV-10 isoform 2

    See identical proteins and their annotated locations for NP_001273001.1

    Status: VALIDATED

    Source sequence(s)
    AB046851, AL603832, BU623853
    Consensus CDS
    CCDS65615.1
    UniProtKB/Swiss-Prot
    Q9HCE1
    UniProtKB/TrEMBL
    Q5JR04
    Related
    ENSP00000358658.1, OTTHUMP00000013678, ENST00000369644.5, OTTHUMT00000032908
    Conserved Domains (2) summary
    pfam13087
    Location:642866
    AAA_12; AAA domain
    cl26261
    Location:429888
    AAA_11; AAA domain
  3. NM_001321324.1NP_001308253.1  putative helicase MOV-10 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL603832
    Consensus CDS
    CCDS853.1
    UniProtKB/Swiss-Prot
    Q9HCE1
    Related
    ENSP00000358659.1, OTTHUMP00000013680, ENST00000369645.5, OTTHUMT00000032911
    Conserved Domains (2) summary
    pfam13087
    Location:698922
    AAA_12; AAA domain
    cl26261
    Location:485944
    AAA_11; AAA domain
  4. NM_020963.4NP_066014.1  putative helicase MOV-10 isoform 1

    See identical proteins and their annotated locations for NP_066014.1

    Status: VALIDATED

    Source sequence(s)
    BC009312, BU623853, DB066263
    Consensus CDS
    CCDS853.1
    UniProtKB/Swiss-Prot
    Q9HCE1
    Related
    ENSP00000399797.2, OTTHUMP00000013677, ENST00000413052.6, OTTHUMT00000032906
    Conserved Domains (2) summary
    pfam13087
    Location:698922
    AAA_12; AAA domain
    cl26261
    Location:485944
    AAA_11; AAA domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    112674312..112702377
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005270870.5XP_005270927.1  putative helicase MOV-10 isoform X2

    See identical proteins and their annotated locations for XP_005270927.1

    UniProtKB/Swiss-Prot
    Q9HCE1
    UniProtKB/TrEMBL
    Q5JR04
    Conserved Domains (2) summary
    pfam13087
    Location:642866
    AAA_12; AAA domain
    cl26261
    Location:429888
    AAA_11; AAA domain
  2. XM_005270869.4XP_005270926.1  putative helicase MOV-10 isoform X2

    See identical proteins and their annotated locations for XP_005270926.1

    UniProtKB/Swiss-Prot
    Q9HCE1
    UniProtKB/TrEMBL
    Q5JR04
    Conserved Domains (2) summary
    pfam13087
    Location:642866
    AAA_12; AAA domain
    cl26261
    Location:429888
    AAA_11; AAA domain
  3. XM_017001318.2XP_016856807.1  putative helicase MOV-10 isoform X2

    UniProtKB/Swiss-Prot
    Q9HCE1
    UniProtKB/TrEMBL
    Q5JR04
    Conserved Domains (2) summary
    pfam13087
    Location:642866
    AAA_12; AAA domain
    cl26261
    Location:429888
    AAA_11; AAA domain
  4. XM_024447137.1XP_024302905.1  putative helicase MOV-10 isoform X4

    Conserved Domains (1) summary
    cl26261
    Location:485836
    AAA_11; AAA domain
  5. XM_017001319.2XP_016856808.1  putative helicase MOV-10 isoform X3

  6. XM_024447132.1XP_024302900.1  putative helicase MOV-10 isoform X1

    Related
    ENSP00000350028.2, ENST00000357443.2
    Conserved Domains (2) summary
    pfam13087
    Location:698922
    AAA_12; AAA domain
    cl26261
    Location:485944
    AAA_11; AAA domain

RNA

  1. XR_001737186.2 RNA Sequence

  2. XR_001737185.2 RNA Sequence

    Related
    ENST00000496577.5
  3. XR_946657.2 RNA Sequence

  4. XR_001737187.2 RNA Sequence

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