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MOV10 Mov10 RISC complex RNA helicase [ Homo sapiens (human) ]

Gene ID: 4343, updated on 22-Aug-2020

Summary

Official Symbol
MOV10provided by HGNC
Official Full Name
Mov10 RISC complex RNA helicaseprovided by HGNC
Primary source
HGNC:HGNC:7200
See related
Ensembl:ENSG00000155363 MIM:610742
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
gb110; fSAP113
Expression
Ubiquitous expression in placenta (RPKM 19.5), small intestine (RPKM 18.6) and 25 other tissues See more
Orthologs

Genomic context

See MOV10 in Genome Data Viewer
Location:
1p13.2
Exon count:
23
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (112674312..112702377)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (113217048..113243368)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene capping actin protein of muscle Z-line subunit alpha 1 Neighboring gene mitochondrial ribosomal protein L53 pseudogene 1 Neighboring gene RNA, U7 small nuclear 70 pseudogene Neighboring gene Sharpr-MPRA regulatory region 4682 Neighboring gene ras homolog family member C Neighboring gene uncharacterized LOC105378910 Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent 1J

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.
GeneReviews: Not available
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
GeneReviews: Not available
Genome-wide association study in Chinese identifies novel loci for blood pressure and hypertension.
GeneReviews: Not available

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated (2019-03-12)

ClinGen Genome Curation Page
Haploinsufficency

No evidence available (Last evaluated (2019-03-12)

ClinGen Genome Curation PagePubMed

HIV-1 interactions

Replication interactions

Interaction Pubs
siRNA-mediated knockdown of endogeneous MOV10 impairs HIV-1 virus production and Gag expression in 293T cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify Moloney leukemia virus 10 homolog (MOV10), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify Moloney leukemia virus 10 homolog (MOV10), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify Moloney leukemia virus 10 homolog (MOV10), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag siRNA-mediated knockdown of endogeneous MOV10 impairs HIV-1 virus production and Gag expression in 293T cells PubMed
gag Tandem affinity purification and mass spectrometry analysis identify Moloney leukemia virus 10 homolog (MOV10), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
gag Overexpression of the Mov10 mutants, G681A/D682A and R730A/N731A, impairs Mov10-mediated decrease of HIV-1 Gag expression in cells and the incorporation efficiency of Mov10 into particles PubMed
gag The efficiency of incorporation of Mov10, A3G, and A3F into viral particles, which contains both HIV-1 Gag and genomic RNA, is much higher than that of the other P-body proteins AGO2, DCP1a, DCP2, and DDX6 PubMed
gag Mov10 overexpression results in translational repression of HIV-1 Gag and that AGO2 and/or RISC function is required to induce this translational repression PubMed
gag Overexpression of A3G and Mov10 decreases the efficiency of HIV-1 Gag processing in the virus-producing cells PubMed
gag MOV10 is packaged into HIV-1 virions in an RNA-dependent manner via an interaction with the NC domain of Gag PubMed
gag HIV-1 Gag binds to the N-terminal amino acids 261-305 region of MOV10. The seven helicase motifs of MOV10 are not required for its interaction with Gag, while all but one of them (motif V) are required for MOV10 packaging into virions PubMed
Rev rev HIV-1 Rev requires MOV10 helicase activity for enhanced function PubMed
rev HIV-1 Rev interacts with Rev PubMed
rev Rev/RRE expression is specifically upregulated by MOV10 in a Rev/RRE-dependent reprter gene assay PubMed
nucleocapsid gag MOV10 is packaged into HIV-1 virions in an RNA-dependent manner via an interaction with the NC domain of Gag PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ32791, KIAA1631, DKFZp667O1423

Gene Ontology Provided by GOA

Function Evidence Code Pubs
5'-3' RNA helicase activity IDA
Inferred from Direct Assay
more info
PubMed 
ATP binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding HDA PubMed 
RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
3'-UTR-mediated mRNA destabilization IDA
Inferred from Direct Assay
more info
PubMed 
Wnt signaling pathway, calcium modulating pathway TAS
Traceable Author Statement
more info
 
defense response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
gene silencing by miRNA IMP
Inferred from Mutant Phenotype
more info
PubMed 
mRNA cleavage involved in gene silencing by miRNA IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of gene expression TAS
Traceable Author Statement
more info
 
negative regulation of transposition, RNA-mediated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of gene expression TAS
Traceable Author Statement
more info
 
positive regulation of mRNA catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
posttranscriptional gene silencing by RNA IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of megakaryocyte differentiation TAS
Traceable Author Statement
more info
 
regulation of neuron projection arborization ISS
Inferred from Sequence or Structural Similarity
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
P granule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
P-body IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic ribonucleoprotein granule IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic stress granule IEA
Inferred from Electronic Annotation
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular space HDA PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
viral replication complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
helicase MOV-10
Names
Mov10, Moloney leukemia virus 10, homolog
armitage homolog
functional spliceosome-associated protein 113
moloney leukemia virus 10 protein
putative helicase MOV-10
NP_001123551.1
NP_001273001.1
NP_001308253.1
NP_001356436.1
NP_066014.1
XP_005270926.1
XP_005270927.1
XP_016856807.1
XP_016856808.1
XP_024302905.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130079.2NP_001123551.1  helicase MOV-10 isoform 1

    See identical proteins and their annotated locations for NP_001123551.1

    Status: VALIDATED

    Source sequence(s)
    AK226011, AL603832, BU623853
    Consensus CDS
    CCDS853.1
    UniProtKB/Swiss-Prot
    Q9HCE1
    Conserved Domains (2) summary
    cd18808
    Location:734939
    SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
    cd18038
    Location:498733
    DEXXQc_Helz-like; DEXXQ/H-box helicase domain of Helz-like helicase
  2. NM_001286072.1NP_001273001.1  helicase MOV-10 isoform 2

    See identical proteins and their annotated locations for NP_001273001.1

    Status: VALIDATED

    Source sequence(s)
    AB046851, AL603832, BU623853
    Consensus CDS
    CCDS65615.1
    UniProtKB/Swiss-Prot
    Q9HCE1
    UniProtKB/TrEMBL
    Q5JR04
    Related
    ENSP00000358658.1, ENST00000369644.5
    Conserved Domains (2) summary
    pfam13087
    Location:642866
    AAA_12; AAA domain
    cl26261
    Location:429888
    AAA_11; AAA domain
  3. NM_001321324.1NP_001308253.1  helicase MOV-10 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL603832
    Consensus CDS
    CCDS853.1
    UniProtKB/Swiss-Prot
    Q9HCE1
    Related
    ENSP00000358659.1, ENST00000369645.5
    Conserved Domains (2) summary
    cd18808
    Location:734939
    SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
    cd18038
    Location:498733
    DEXXQc_Helz-like; DEXXQ/H-box helicase domain of Helz-like helicase
  4. NM_001369507.1NP_001356436.1  helicase MOV-10 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL603832
    Related
    ENSP00000350028.2, ENST00000357443.2
    Conserved Domains (2) summary
    cd18808
    Location:734939
    SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
    cd18038
    Location:498733
    DEXXQc_Helz-like; DEXXQ/H-box helicase domain of Helz-like helicase
  5. NM_020963.4NP_066014.1  helicase MOV-10 isoform 1

    See identical proteins and their annotated locations for NP_066014.1

    Status: VALIDATED

    Source sequence(s)
    BC009312, BU623853, DB066263
    Consensus CDS
    CCDS853.1
    UniProtKB/Swiss-Prot
    Q9HCE1
    Related
    ENSP00000399797.2, ENST00000413052.6
    Conserved Domains (2) summary
    cd18808
    Location:734939
    SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
    cd18038
    Location:498733
    DEXXQc_Helz-like; DEXXQ/H-box helicase domain of Helz-like helicase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    112674312..112702377
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005270870.5XP_005270927.1  helicase MOV-10 isoform X2

    See identical proteins and their annotated locations for XP_005270927.1

    UniProtKB/Swiss-Prot
    Q9HCE1
    UniProtKB/TrEMBL
    Q5JR04
    Conserved Domains (2) summary
    pfam13087
    Location:642866
    AAA_12; AAA domain
    cl26261
    Location:429888
    AAA_11; AAA domain
  2. XM_005270869.4XP_005270926.1  helicase MOV-10 isoform X2

    See identical proteins and their annotated locations for XP_005270926.1

    UniProtKB/Swiss-Prot
    Q9HCE1
    UniProtKB/TrEMBL
    Q5JR04
    Conserved Domains (2) summary
    pfam13087
    Location:642866
    AAA_12; AAA domain
    cl26261
    Location:429888
    AAA_11; AAA domain
  3. XM_017001318.2XP_016856807.1  helicase MOV-10 isoform X2

    UniProtKB/Swiss-Prot
    Q9HCE1
    UniProtKB/TrEMBL
    Q5JR04
    Conserved Domains (2) summary
    pfam13087
    Location:642866
    AAA_12; AAA domain
    cl26261
    Location:429888
    AAA_11; AAA domain
  4. XM_024447137.1XP_024302905.1  helicase MOV-10 isoform X4

    Conserved Domains (1) summary
    cl26261
    Location:485836
    AAA_11; AAA domain
  5. XM_017001319.2XP_016856808.1  helicase MOV-10 isoform X3

RNA

  1. XR_001737186.2 RNA Sequence

  2. XR_001737185.2 RNA Sequence

  3. XR_946657.2 RNA Sequence

  4. XR_001737187.2 RNA Sequence

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