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Whamm WAS protein homolog associated with actin, golgi membranes and microtubules [ Mus musculus (house mouse) ]

Gene ID: 434204, updated on 13-May-2024

Summary

Official Symbol
Whammprovided by MGI
Official Full Name
WAS protein homolog associated with actin, golgi membranes and microtubulesprovided by MGI
Primary source
MGI:MGI:2142282
See related
Ensembl:ENSMUSG00000045795 AllianceGenome:MGI:2142282
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Whdc1; mKIAA1971
Summary
Predicted to enable Arp2/3 complex binding activity; microtubule binding activity; and small GTPase binding activity. Involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Predicted to be located in Golgi membrane and cytosol. Predicted to be active in endoplasmic reticulum-Golgi intermediate compartment membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and integumental system. Orthologous to human WHAMM (WASP homolog associated with actin, golgi membranes and microtubules). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 16.4), liver adult (RPKM 13.9) and 28 other tissues See more
Orthologs
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Genomic context

See Whamm in Genome Data Viewer
Location:
7 D3; 7 45.71 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (81220403..81246585)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (81570655..81596837)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2900076A07 gene Neighboring gene microRNA 1839 Neighboring gene fibronectin type III and SPRY domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_19369 Neighboring gene STARR-positive B cell enhancer mm9_chr7:88715937-88716238 Neighboring gene homer scaffolding protein 2 Neighboring gene microRNA 12203 Neighboring gene predicted gene, 32579

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA1971, MGC51670, MGC58752

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Arp2/3 complex binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables Arp2/3 complex binding ISO
Inferred from Sequence Orthology
more info
 
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in endoplasmic reticulum-Golgi intermediate compartment membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum-Golgi intermediate compartment membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
WASP homolog-associated protein with actin, membranes and microtubules
Names
WAS protein homology region 2 domain containing 1
WAS protein homology region 2 domain-containing protein 1
WH2 domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004185.4NP_001004185.3  WASP homolog-associated protein with actin, membranes and microtubules

    See identical proteins and their annotated locations for NP_001004185.3

    Status: VALIDATED

    Source sequence(s)
    AC140366
    Consensus CDS
    CCDS52283.1
    UniProtKB/Swiss-Prot
    Q571B6, Q80VK9, Q80YT0, Q8BJP8
    Related
    ENSMUSP00000128881.2, ENSMUST00000165460.2
    Conserved Domains (2) summary
    pfam15871
    Location:67435
    JMY; Junction-mediating and -regulatory protein
    pfam15920
    Location:551
    WHAMM-JMY_N; N-terminal of Junction-mediating and WASP homolog-associated

RNA

  1. NR_185074.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC140366
  2. NR_185075.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC140366
  3. NR_185076.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC140366
  4. NR_185077.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC140366
  5. NR_185078.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC140366
  6. NR_185079.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC140366

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    81220403..81246585
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_004934126.1 RNA Sequence

  2. XR_004934128.1 RNA Sequence