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Whamm WAS protein homolog associated with actin, golgi membranes and microtubules [ Mus musculus (house mouse) ]

Gene ID: 434204, updated on 26-Sep-2022

Summary

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Official Symbol
Whammprovided by MGI
Official Full Name
WAS protein homolog associated with actin, golgi membranes and microtubulesprovided by MGI
Primary source
MGI:MGI:2142282
See related
Ensembl:ENSMUSG00000045795 AllianceGenome:MGI:2142282
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Whdc1; mKIAA1971
Summary
Predicted to enable Arp2/3 complex binding activity; microtubule binding activity; and small GTPase binding activity. Involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Predicted to be located in Golgi membrane and cytosol. Predicted to be active in endoplasmic reticulum-Golgi intermediate compartment membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and integumental system. Orthologous to human WHAMM (WASP homolog associated with actin, golgi membranes and microtubules). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 16.4), liver adult (RPKM 13.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Whamm in Genome Data Viewer
Location:
7; 7 D3
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (81220403..81246585)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (81570655..81596837)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2900076A07 gene Neighboring gene microRNA 1839 Neighboring gene fibronectin type III and SPRY domain containing 2 Neighboring gene homer scaffolding protein 2 Neighboring gene microRNA 12203 Neighboring gene predicted gene, 32579

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. WHAMM is required for meiotic spindle migration and asymmetric cytokinesis in mouse oocytes. Huang X, et al. Histochem Cell Biol, 2013 Apr. PMID 23160625
  2. WHAMM is an Arp2/3 complex activator that binds microtubules and functions in ER to Golgi transport. Campellone KG, et al. Cell, 2008 Jul 11. PMID 18614018, Free PMC Article
  3. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (16) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. data suggest that WHAMM is required for peripheral spindle migration and asymmetric cytokinesis during mouse oocyte maturation
    Title: WHAMM is required for meiotic spindle migration and asymmetric cytokinesis in mouse oocytes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1971, MGC51670, MGC58752

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Arp2/3 complex binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables Arp2/3 complex binding ISO
Inferred from Sequence Orthology
more info
  
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Arp2/3 complex-mediated actin nucleation IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in actin filament organization ISO
Inferred from Sequence Orthology
more info
  
involved_in actin filament reorganization ISO
Inferred from Sequence Orthology
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
  
involved_in focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in lamellipodium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in plasma membrane tubulation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of actin nucleation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum-Golgi intermediate compartment membrane IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in endoplasmic reticulum-Golgi intermediate compartment membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
WASP homolog-associated protein with actin, membranes and microtubules
Names
WAS protein homology region 2 domain containing 1
WAS protein homology region 2 domain-containing protein 1
WH2 domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004185.3 → NP_001004185.3  WASP homolog-associated protein with actin, membranes and microtubules

    See identical proteins and their annotated locations for NP_001004185.3

    Status: PROVISIONAL

    Source sequence(s)
    AK220273
    Consensus CDS
    CCDS52283.1
    UniProtKB/Swiss-Prot
    Q571B6, Q8BJP8
    Related
    ENSMUSP00000128881.2, ENSMUST00000165460.2
    Conserved Domains (2) summary
    pfam15871
    Location:67 → 435
    JMY; Junction-mediating and -regulatory protein
    pfam15920
    Location:5 → 51
    WHAMM-JMY_N; N-terminal of Junction-mediating and WASP homolog-associated

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    81220403..81246585
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540981.4 → XP_006541044.1  WASP homolog-associated protein with actin, membranes and microtubules isoform X1

    Conserved Domains (1) summary
    pfam15871
    Location:1 → 130
    JMY; Junction-mediating and -regulatory protein

  2. XM_030242741.1 → XP_030098601.1  WASP homolog-associated protein with actin, membranes and microtubules isoform X1

    Conserved Domains (1) summary
    pfam15871
    Location:1 → 130
    JMY; Junction-mediating and -regulatory protein

RNA

  1. XR_004934126.1 RNA Sequence

  2. XR_004934128.1 RNA Sequence

  3. XR_003946503.2 RNA Sequence

  4. XR_003946502.2 RNA Sequence

  5. XR_004934127.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q571B6.2 GenPept UniProtKB/Swiss-Prot:Q571B6

Gene LinkOut

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