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MOG myelin oligodendrocyte glycoprotein [ Homo sapiens (human) ]

Gene ID: 4340, updated on 2-Sep-2018

Summary

Official Symbol
MOGprovided by HGNC
Official Full Name
myelin oligodendrocyte glycoproteinprovided by HGNC
Primary source
HGNC:HGNC:7197
See related
Ensembl:ENSG00000204655 MIM:159465; Vega:OTTHUMG00000031099
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BTN6; BTNL11; MOGIG2; NRCLP7
Summary
The product of this gene is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Due to this localization, it is a primary target antigen involved in immune-mediated demyelination. This protein may be involved in completion and maintenance of the myelin sheath and in cell-cell communication. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward brain (RPKM 52.4) See more
Orthologs

Genomic context

See MOG in Genome Data Viewer
Location:
6p22.1
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 6 NC_000006.12 (29656981..29672372)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (29624758..29640149)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene gamma-aminobutyric acid type B receptor subunit 1 Neighboring gene SUMO2 pseudogene 1 Neighboring gene ZFP57 zinc finger protein Neighboring gene zinc finger DHHC-type containing 20 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Narcolepsy 7
MedGen: C3280266 OMIM: 614250 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
NHGRI GWA Catalog
Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC26137

Gene Ontology Provided by GOA

Function Evidence Code Pubs
signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
virus receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
T cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
central nervous system development TAS
Traceable Author Statement
more info
PubMed 
regulation of immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
viral entry into host cell IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
myelin-oligodendrocyte glycoprotein
Names
MOG AluA
MOG AluB
MOG Ig-AluB
MOG alpha-5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_031873.1 RefSeqGene

    Range
    5001..20392
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001008228.2NP_001008229.1  myelin-oligodendrocyte glycoprotein isoform alpha3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (alpha3) has multiple differences in the coding region, compared to variant beta1. Alpha type variants use an alternative splice site at the 3' end, compared to isoform beta1. The resulting isoform (alpha3) is shorter and contains a shorter and distinct C-terminus, compared to isoform beta1.
    Source sequence(s)
    AL119259, DA139582, DA140757, DA253273, U18843, U64564
    Consensus CDS
    CCDS34369.1
    UniProtKB/Swiss-Prot
    Q16653
    Related
    ENSP00000379932.3, OTTHUMP00000029127, ENST00000396704.7, OTTHUMT00000076161
    Conserved Domains (2) summary
    cd05713
    Location:46144
    Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
    smart00410
    Location:40144
    IG_like; Immunoglobulin like
  2. NM_001008229.2NP_001008230.1  myelin-oligodendrocyte glycoprotein isoform beta2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (beta2) lacks an in-frame segment of the coding region, compared to variant beta1. It encodes a shorter isoform (beta2), that is missing an internal segment, compared to isoform beta1.
    Source sequence(s)
    AL119259, AY566853, DA139582, DA140757, DA253273, U64564
    Consensus CDS
    CCDS34368.1
    UniProtKB/Swiss-Prot
    Q16653
    Related
    ENSP00000366088.4, OTTHUMP00000029121, ENST00000376891.8, OTTHUMT00000076155
    Conserved Domains (2) summary
    cd05713
    Location:46144
    Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
    smart00410
    Location:40144
    IG_like; Immunoglobulin like
  3. NM_001170418.1NP_001163889.1  myelin-oligodendrocyte glycoprotein isoform alpha6 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (alpha6) lacks an alternate in-frame exon in the 5' coding region and differs in the 3' coding region and 3' UTR, compared to variant beta1. The encoded isoform (alpha6) has a distinct C-terminus and is shorter than isoform beta1.
    Source sequence(s)
    AL119259, AY566847, DA139582, DA140757, DA253273, U64564
    Consensus CDS
    CCDS54977.1
    UniProtKB/Swiss-Prot
    Q16653
    Related
    ENSP00000420350.1, OTTHUMP00000214868, ENST00000490427.5, OTTHUMT00000354636
  4. NM_001363610.1NP_001350539.1  myelin-oligodendrocyte glycoprotein isoform 10 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) represents the longest transcript and encodes the longest isoform (10).
    Source sequence(s)
    AL645936, BC035938
    Consensus CDS
    CCDS87379.1
    Conserved Domains (1) summary
    cd05713
    Location:46144
    Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
  5. NM_002433.4NP_002424.3  myelin-oligodendrocyte glycoprotein isoform beta1 precursor

    See identical proteins and their annotated locations for NP_002424.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (beta1) encodes the beta1 isoform, also known as isoform 1.
    Source sequence(s)
    AL119259, AY566852, DA139582, DA140757, DA253273, U64564
    Consensus CDS
    CCDS4667.1
    UniProtKB/Swiss-Prot
    Q16653
    UniProtKB/TrEMBL
    Q5SSB8
    Related
    ENSP00000366095.3, OTTHUMP00000029122, ENST00000376898.7, OTTHUMT00000076156
    Conserved Domains (2) summary
    cd05713
    Location:46144
    Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
    smart00410
    Location:40144
    IG_like; Immunoglobulin like
  6. NM_206809.3NP_996532.2  myelin-oligodendrocyte glycoprotein isoform alpha1 precursor

    See identical proteins and their annotated locations for NP_996532.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (alpha1) contains an additional segment in the coding region compared to variant beta1. Alpha type variants use an alternative splice site at the 3' end, compared to variant beta1. The resulting isoform (alpha1), also known as isoform 2, contains a shorter and distinct C-terminus compared to isoform beta1.
    Source sequence(s)
    AL119259, DA139582, DA140757, DA253273, U64564, X74511
    Consensus CDS
    CCDS34370.1
    UniProtKB/Swiss-Prot
    Q16653
    Related
    ENSP00000366115.3, OTTHUMP00000029126, ENST00000376917.7, OTTHUMT00000076160
    Conserved Domains (2) summary
    cd05713
    Location:46144
    Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
    smart00410
    Location:40144
    IG_like; Immunoglobulin like
  7. NM_206810.3NP_996533.2  myelin-oligodendrocyte glycoprotein isoform beta5 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (beta5) lacks an in-frame segment of the coding region, compared to variant beta1. It encodes a shorter isoform (beta5), also known as isoform 3, that is missing an internal segment, compared to isoform beta1.
    Source sequence(s)
    AL119259, DA139582, DA140757, DA253273, U18803, U64564
    Consensus CDS
    CCDS34367.1
    UniProtKB/Swiss-Prot
    Q16653
    Related
    ENSP00000379929.2, OTTHUMP00000029124, ENST00000396701.6, OTTHUMT00000076158
    Conserved Domains (2) summary
    cd05713
    Location:46144
    Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
    smart00410
    Location:40144
    IG_like; Immunoglobulin like
  8. NM_206811.3NP_996534.2  myelin-oligodendrocyte glycoprotein isoform beta3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (beta3) has multiple differences in the coding region, compared to variant beta1. The resulting isoform (beta3), also known as isoform 4, is shorter, compared to isoform beta1.
    Source sequence(s)
    AL119259, DA139582, DA140757, DA253273, U18840, U64564
    Consensus CDS
    CCDS34366.1
    UniProtKB/Swiss-Prot
    Q16653
    Related
    ENSP00000417405.1, OTTHUMP00000029125, ENST00000494692.5, OTTHUMT00000076159
    Conserved Domains (2) summary
    cd05713
    Location:46144
    Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
    smart00410
    Location:40144
    IG_like; Immunoglobulin like
  9. NM_206812.3NP_996535.2  myelin-oligodendrocyte glycoprotein isoform alpha2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (alpha2) has multiple differences in the coding region, compared to variant beta1. Alpha type variants use an alternative splice site at the 3' end, compared to isoform beta1. The resulting isoform (alpha2), also known as isoform 5, is shorter and contains a shorter and distinct C-terminus, compared to isoform beta1.
    Source sequence(s)
    AL119259, DA139582, DA140757, DA253273, U18799, U64564
    Consensus CDS
    CCDS47394.1
    UniProtKB/Swiss-Prot
    Q16653
    Related
    ENSP00000410866.2, OTTHUMP00000029123, ENST00000431798.6, OTTHUMT00000076157
    Conserved Domains (2) summary
    cd05713
    Location:46144
    Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
    smart00410
    Location:40144
    IG_like; Immunoglobulin like
  10. NM_206814.5NP_996537.3  myelin-oligodendrocyte glycoprotein isoform alpha5 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (alpha5) lacks an alternate in-frame exon in the 5' coding region and differs in the 3' coding region and 3' UTR, compared to variant beta1. The encoded isoform (alpha5) has a distinct C-terminus and is shorter than isoform beta1.
    Source sequence(s)
    AK308949, AL119259, DA139582, DA140757, DA253273, U64564
    Consensus CDS
    CCDS47395.2
    UniProtKB/Swiss-Prot
    Q16653
    Related
    ENSP00000366085.2, OTTHUMP00000029120, ENST00000376888.6, OTTHUMT00000076154

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p12 Primary Assembly

    Range
    29656981..29672372
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005249131.4XP_005249188.1  myelin-oligodendrocyte glycoprotein isoform X1

    UniProtKB/Swiss-Prot
    Q16653
    Related
    ENSP00000366091.4, OTTHUMP00000109158, ENST00000376894.8
    Conserved Domains (1) summary
    cd05713
    Location:46144
    Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)

Reference GRCh38.p12 ALT_REF_LOCI_1

Genomic

  1. NT_167244.2 Reference GRCh38.p12 ALT_REF_LOCI_1

    Range
    922690..938080
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_2

Genomic

  1. NT_113891.3 Reference GRCh38.p12 ALT_REF_LOCI_2

    Range
    1143453..1158845
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_3

Genomic

  1. NT_167245.2 Reference GRCh38.p12 ALT_REF_LOCI_3

    Range
    922526..937918
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_4

Genomic

  1. NT_167246.2 Reference GRCh38.p12 ALT_REF_LOCI_4

    Range
    922098..937486
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_5

Genomic

  1. NT_167247.2 Reference GRCh38.p12 ALT_REF_LOCI_5

    Range
    922362..937746
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_6

Genomic

  1. NT_167248.2 Reference GRCh38.p12 ALT_REF_LOCI_6

    Range
    922481..937873
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_7

Genomic

  1. NT_167249.2 Reference GRCh38.p12 ALT_REF_LOCI_7

    Range
    966016..981404
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_206813.4: Suppressed sequence

    Description
    NM_206813.4: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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