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Trim63 tripartite motif-containing 63 [ Mus musculus (house mouse) ]

Gene ID: 433766, updated on 5-Aug-2018

Summary

Official Symbol
Trim63provided by MGI
Official Full Name
tripartite motif-containing 63provided by MGI
Primary source
MGI:MGI:2447992
See related
Ensembl:ENSMUSG00000028834 Vega:OTTMUSG00000010606
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RF1; MuRF1; Rnf28
Expression
Biased expression in heart adult (RPKM 54.2) and mammary gland adult (RPKM 5.3) See more
Orthologs

Genomic context

See Trim63 in Genome Data Viewer
Location:
4; 4 D3
Exon count:
9
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (134315120..134329629)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (133871035..133885544)

Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene glycine/arginine rich protein 1 Neighboring gene predicted gene, 42325 Neighboring gene PDLIM1 interacting kinase 1 like Neighboring gene solute carrier family 30 (zinc transporter), member 2 Neighboring gene exostoses (multiple)-like 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
titin binding ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
contractile fiber ISO
Inferred from Sequence Orthology
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
intracellular IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase TRIM63
Names
MURF-1
RING-type E3 ubiquitin transferase TRIM63
muscle ring finger protein 1
muscle-specific RING finger protein 1
ring finger protein 28
tripartite motif-containing protein 63
NP_001034137.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039048.2NP_001034137.2  E3 ubiquitin-protein ligase TRIM63

    See identical proteins and their annotated locations for NP_001034137.2

    Status: VALIDATED

    Source sequence(s)
    AJ278734, AL627253, AL627314, CJ131880, CK128385
    Consensus CDS
    CCDS38914.1
    UniProtKB/TrEMBL
    F8VPZ1, Q8CFN7
    Related
    ENSMUSP00000101501.1, ENSMUST00000105875.7
    Conserved Domains (3) summary
    cd00162
    Location:2382
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam00643
    Location:120159
    zf-B_box; B-box zinc finger
    cl23765
    Location:166283
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

    Range
    134315120..134329629
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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