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Ankrd13c ankyrin repeat domain 13c [ Mus musculus (house mouse) ]

Gene ID: 433667, updated on 26-Sep-2022

Summary

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Official Symbol
Ankrd13cprovided by MGI
Official Full Name
ankyrin repeat domain 13cprovided by MGI
Primary source
MGI:MGI:2139746
See related
Ensembl:ENSMUSG00000039988 AllianceGenome:MGI:2139746
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable signaling receptor binding activity. Predicted to be involved in protein retention in ER lumen; regulation of anoikis; and regulation of signaling receptor activity. Predicted to be located in endoplasmic reticulum and perinuclear region of cytoplasm. Predicted to be active in cytoplasm. Is expressed in alimentary system; cranial ganglion; dorsal root ganglion; and liver. Orthologous to human ANKRD13C (ankyrin repeat domain 13C). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 24.1), kidney adult (RPKM 16.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ankrd13c in Genome Data Viewer
Location:
3; 3 H4
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (157650886..157713671)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (157945420..158008034)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene cystathionase (cystathionine gamma-lyase) Neighboring gene RIKEN cDNA 1810013D15 gene Neighboring gene serine and arginine-rich splicing factor 11 Neighboring gene leucine rich repeat containing 40

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ANKRD13C acts as a molecular chaperone for G protein-coupled receptors. Parent A, et al. J Biol Chem, 2010 Dec 24. PMID 20959461, Free PMC Article
  2. Assembly, verification, and initial annotation of the NIA mouse 7.4K cDNA clone set. VanBuren V, et al. Genome Res, 2002 Dec. PMID 12466305, Free PMC Article
  3. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in protein retention in ER lumen IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in protein retention in ER lumen ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of anoikis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of signaling receptor activity ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
colocalizes_with endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ankyrin repeat domain-containing protein 13C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013806.2 → NP_001013828.1  ankyrin repeat domain-containing protein 13C isoform 1

    See identical proteins and their annotated locations for NP_001013828.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC117211, AC145301, AI835245, AK135906, BC065088, BQ562764, CF736962
    Consensus CDS
    CCDS17933.1
    UniProtKB/Swiss-Prot
    Q3UX43, Q6P1G4
    Related
    ENSMUSP00000038662.9, ENSMUST00000040787.13
    Conserved Domains (4) summary
    cd00204
    Location:115 → 199
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam11904
    Location:259 → 532
    GPCR_chapero_1; GPCR-chaperone
    pfam13637
    Location:144 → 197
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:115 → 141
    ANK; ANK repeat [structural motif]

  2. NM_001359909.1 → NP_001346838.1  ankyrin repeat domain-containing protein 13C isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5'UTR and initiates translation at a downstream start codon, compared to variant (1). The encoded isoform (2) has a shorter N-terminus, compared to isoform (1).
    Source sequence(s)
    AC117211, AC145301, AI835245
    Conserved Domains (1) summary
    pfam11904
    Location:1 → 263
    GPCR_chapero_1; GPCR-chaperone

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    157650886..157713671
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163152.1 → XP_036019045.1  ankyrin repeat domain-containing protein 13C isoform X2

    Conserved Domains (1) summary
    pfam11904
    Location:17 → 289
    GPCR_chapero_1; GPCR-chaperone

  2. XM_036163151.1 → XP_036019044.1  ankyrin repeat domain-containing protein 13C isoform X1

    Conserved Domains (3) summary
    sd00045
    Location:115 → 141
    ANK; ANK repeat [structural motif]
    pfam11904
    Location:259 → 302
    GPCR_chapero_1; GPCR-chaperone
    pfam12796
    Location:117 → 199
    Ank_2; Ankyrin repeats (3 copies)

RNA

  1. XR_004941350.1 RNA Sequence

  2. XR_003954348.2 RNA Sequence

  3. XR_004941351.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UX43.2 GenPept UniProtKB/Swiss-Prot:Q3UX43

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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